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    Container closure delivery system
    1.
    发明申请
    Container closure delivery system 有权
    集装箱运输系统

    公开(公告)号：US20070225640A1

    公开(公告)日：2007-09-27

    申请号：US11716223

    申请日：2007-03-09

    申请人： Byeong Chang ,  Roger Liu

    发明人： Byeong Chang ,  Roger Liu

    IPC分类号： A61M37/00

    CPC分类号： A61M5/31 ,  A61J1/2096 ,  A61M5/2448 ,  A61M5/31596 ,  A61M5/3294 ,  A61M5/34 ,  A61M5/345 ,  A61M2005/312 ,  A61M2005/3128 ,  A61M2005/3132 ,  A61M2005/31598

    摘要： A container closure delivery system that is suitable for lyophilized pharmaceutical injectable powder products is disclosed. The system comprises storage stable powder formulations and a container closure assembly design wherein the formulation can be filled and lyophilized with a standard fill finish equipment, and the formulations and lyophilization processes are optimized to produce a powder that readily dissolves upon contact with a diluent, thereby facilitating the direct injection of the lyophilized product without the need for a separate reconstitution/mixing/priming step.

    摘要翻译： 公开了适用于冻干药物可注射粉末产品的容器封闭递送系统。 该系统包括储存稳定的粉末制剂和容器封闭组件设计，其中可以用标准填充装置填充和冻干制剂，并优化制剂和冻干方法以产生在与稀释剂接触时容易溶解的粉末，从而 促进直接注射冻干产品，而不需要单独的重建/混合/起动步骤。

    PHARMACEUTICAL FORMULATIONS OF GHRH MOLECULES
    3.
    发明申请
    PHARMACEUTICAL FORMULATIONS OF GHRH MOLECULES 审中-公开
    GHRH分子的药物制剂

    公开(公告)号：US20080249017A1

    公开(公告)日：2008-10-09

    申请号：US12098298

    申请日：2008-04-04

    申请人： Helen Loughrey ,  Byeong Chang

    发明人： Helen Loughrey ,  Byeong Chang

    IPC分类号： A61K38/22 ,  A61P3/00 ,  A61P25/00

    CPC分类号： A61K38/25 ,  A61K9/0019 ,  A61K9/19

    摘要： Stabilized solid and liquid pharmaceutical formulations comprising a GHRH molecules as active ingredient, and more particularly GHRH analogs including [trans-3-hexenoyl]hGHRH (1-44) amide, are disclosed. The formulation comprises an anionic surfactant and a non-reducing sugar, and has a pH of about 4.0 to about 7.5. Also disclosed is the use of the formulation for the treatment of various conditions, methods of preparing the formulation, as well as kits containing it.

    摘要翻译： 公开了包含GHRH分子作为活性成分的稳定的固体和液体药物制剂，更具体地，包括[反式-3-己烯酰基] hGHRH（1-44）酰胺）的GHRH类似物。 制剂包含阴离子表面活性剂和非还原糖，并且具有约4.0至约7.5的pH。 还公开了用于治疗各种病症的制剂的用途，制备制剂的方法，以及含有它的试剂盒。

    Computer and control method thereof
    4.
    发明申请
    Computer and control method thereof 审中-公开
    计算机及其控制方法

    公开(公告)号：US20060119485A1

    公开(公告)日：2006-06-08

    申请号：US11264018

    申请日：2005-11-02

    申请人： Byeong-chang Lee ,  Seung-loon Park

    发明人： Byeong-chang Lee ,  Seung-loon Park

    IPC分类号： G08B25/08 ,  H03G5/00

    CPC分类号： G08B13/12 ,  G06F3/16 ,  G08B25/008

    摘要： A computer having a speaker outputting a sound, the computer including: a sound signal output unit outputting a speaker sound signal to the speaker; a speaker output control unit controlling whether the sound signal output unit to output the speaker sound signal; and an alarm control unit controlling the speaker output control unit so that the sound signal output unit outputs the speaker sound signal when a predetermined alarm condition is detected, and the sound signal output unit so that the speaker generates a preset alarm sound to correspond to the alarm condition.

    摘要翻译： 一种具有输出声音的扬声器的计算机，所述计算机包括：声音信号输出单元，向扬声器输出扬声器声音信号; 扬声器输出控制单元，控制声音输出单元是否输出扬声器声音信号; 以及报警控制单元，其控制扬声器输出控制单元，使得当检测到预定的报警条件时，声音信号输出单元输出扬声器声音信号，并且声音输出单元使得扬声器产生预设的报警声音以对应于 报警条件。

    HIGH TEMPERATURE STABLE PEPTIDE FORMULATION
    6.
    发明申请
    HIGH TEMPERATURE STABLE PEPTIDE FORMULATION 有权
    高温稳定肽配方

    公开(公告)号：US20090054331A1

    公开(公告)日：2009-02-26

    申请号：US12129504

    申请日：2008-05-29

    申请人： Dennis CHEN ,  Russell Wayne BLACHER ,  Byeong CHANG

    发明人： Dennis CHEN ,  Russell Wayne BLACHER ,  Byeong CHANG

    IPC分类号： A61K38/16 ,  A61P43/00 ,  B65D85/00

    CPC分类号： A61K38/1709 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  A61K47/183 ,  A61K47/26 ,  C07K14/4702

    摘要： A stabilized pharmaceutical composition in the form of a lyophilized product to be later reconstituted to generate an aqueous drug product is described herein. The therapeutically active ingredient in the form of a peptide of sequence TDLQERGDNDISPFSGDGQPFKD is stabilized with a buffer, carbohydrate stabilizer, a nonionic bulking agent and a surfactant to facilitate reconstitution. The preferred preparation contains a peptide of the sequence TDLQERGDNDISPFSGDGQPFKD, histidine buffer, mannitol or glycine, sucrose and/or Polysorbate 20. This combination of excipients has demonstrated exceptional stability as a lyophilized product when stored at the elevated temperature of 40° C. for at least 6 months and for at least 3 Months at 50° C. The lyophilized mixture thus formed is reconstituted to a high peptide concentration without apparent loss of stability of the peptide. Also, this combination of excipients has also enabled the ability to terminally sterilize the lyophilized product using gamma irradiation without affecting the stability of the active ingredient of the formulation.

    摘要翻译： 本文描述了待再造以产生含水药物产品的冻干产品形式的稳定化药物组合物。 序列TDLQERGDNDISPFSGDGQPFKD的肽形式的治疗活性成分用缓冲液，碳水化合物稳定剂，非离子填充剂和表面活性剂稳定以促进重构。 优选的制剂含有序列TDLQERGDNDISPFSGDGQPFKD，组氨酸缓冲液，甘露醇或甘氨酸，蔗糖和/或聚山梨醇酯20的肽。这种赋形剂的组合已经证明作为冻干产品在40℃升高的温度下储存时具有特别的稳定性， 至少6个月，并且在50℃下至少3个月。由此形成的冻干混合物重构成高肽浓度，而不会明显丧失肽的稳定性。 此外，赋形剂的这种组合也使得能够使用γ辐射对冻干产品进行终末灭菌，而不影响制剂的活性成分的稳定性。

    Multi-functional container closure delivery system
    7.
    发明申请
    Multi-functional container closure delivery system 审中-公开
    多功能集装箱运输系统

    公开(公告)号：US20060157507A1

    公开(公告)日：2006-07-20

    申请号：US11384981

    申请日：2006-03-20

    申请人： Byeong Chang ,  Roger Liu

    发明人： Byeong Chang ,  Roger Liu

    IPC分类号： B67D5/60

    CPC分类号： A61M5/31596 ,  A61M5/2448 ,  A61M2005/312 ,  A61M2005/3128 ,  A61M2005/31598

    摘要： A container closure delivery system that is suitable for lyophilized pharmaceutical injectable powder products is disclosed. The system comprises storage stable powder formulations and a container closure assembly design wherein the formulation can be filled and lyophilized with a standard fill finish equipment, and the formulations and lyophilization processes are optimized to produce a powder that readily dissolves upon contact with a diluent, thereby facilitating the direct injection of the lyophilized product without the need for a separate reconstitution/mixing/priming step. Importantly, the container closure assembly also provides for modularity of dosing, the ability to dose multiple products in a single dose, intranasal delivery, and multi-dosing.

    摘要翻译： 公开了适用于冻干药物可注射粉末产品的容器封闭递送系统。 该系统包括储存稳定的粉末制剂和容器封闭组件设计，其中可以用标准填充装置填充和冻干制剂，并优化制剂和冻干方法以产生在与稀释剂接触时容易溶解的粉末，从而 促进直接注射冻干产品，而不需要单独的重建/混合/起动步骤。 重要的是，容器封闭组件还提供了剂量的模块化，以单一剂量，鼻内递送和多剂量给药多个产品的能力。

    Portable computer having universal serial bus ports controlled power supply and a method of the same
    8.
    发明授权
    Portable computer having universal serial bus ports controlled power supply and a method of the same 有权
    具有通用串行总线端口控制电源的便携式计算机及其方法

    公开(公告)号：US06516418B1

    公开(公告)日：2003-02-04

    申请号：US09360115

    申请日：1999-07-23

    申请人： Byeong-Chang Lee

    发明人： Byeong-Chang Lee

    IPC分类号： G06F126

    CPC分类号： G06F1/3253 ,  G06F1/3203 ,  Y02D10/151

    摘要： A portable computer system with universal serial bus (USB) port or ports and a method for controlling power of the universal serial bus (USB) port is described. When the main power of the portable computer system is supplied from a battery rather than an alternating current (AC) adapter, the power of the universal serial bus (USB) port is automatically shut down. In addition, the power of the universal serial bus (USB ) port is completely shut down while the universal serial bus (USB) port is not used in response to a setting state of the universal serial bus (USB) port, thereby reducing unnecessary power consumption. Further, when an over-current is detected from the alternating current (AC) adapter or the battery, the power of the universal serial bus (USB) port is shut down, whereby damage to peripheral devices coupled to the universal serial bus (USB) port can be prevented.

    摘要翻译： 描述了具有通用串行总线（USB）端口的便携式计算机系统和用于控制通用串行总线（USB）端口的电力的方法。 当便携式计算机系统的主电源是从电池而不是交流（AC）适配器供电时，通用串行总线（USB）端口的电源自动关闭。 此外，通用串行总线（USB）端口的电源完全关闭，而通用串行总线（USB）端口不响应通用串行总线（USB）端口的设置状态，从而减少不必要的电源 消费。 此外，当从交流（AC）适配器或电池检测到过电流时，通用串行总线（USB）端口的电源被关闭，从而损坏耦合到通用串行总线（USB）的外围设备， 端口可以​​防止。

    Container closure delivery system
    10.
    发明申请
    Container closure delivery system 审中-公开
    集装箱运输系统

    公开(公告)号：US20060144869A1

    公开(公告)日：2006-07-06

    申请号：US11172064

    申请日：2005-06-30

    申请人： Byeong Chang ,  Roger Liu

    发明人： Byeong Chang ,  Roger Liu

    IPC分类号： G01F11/00 ,  B67D5/42

    CPC分类号： A61J1/00 ,  A61M5/2448 ,  A61M5/31596 ,  A61M2005/312 ,  A61M2005/3128 ,  A61M2005/31598

    摘要： The present invention relates to a container closure delivery system that is suitable for lyophilized pharmaceutical injectable powder products. The system comprises storage stable powder formulations and a container closure assembly design wherein the formulation can be filled and lyophilized with a standard fill finish equipment, and the formulations and lyophilization processes are optimized to produce a powder that readily dissolves upon contact with a diluent, thereby facilitating the direct injection of the lyophilized product without the need for a separate reconstitution/mixing/priming step.

    摘要翻译： 本发明涉及适用于冻干药物可注射粉末产品的容器封闭递送系统。 该系统包括储存稳定的粉末制剂和容器封闭组件设计，其中可以用标准填充装置填充和冻干制剂，并优化制剂和冻干方法以产生在与稀释剂接触时容易溶解的粉末，从而 促进直接注射冻干产品，而不需要单独的重建/混合/起动步骤。