METHOD OF USING SULFONAMIDE SUBSTITUTED IMIDAZOQUINOLINES
    3.
    发明申请
    METHOD OF USING SULFONAMIDE SUBSTITUTED IMIDAZOQUINOLINES 审中-公开
    使用磺酰胺取代的咪唑啉醇溶液的方法

    公开(公告)号:US20060106052A1

    公开(公告)日:2006-05-18

    申请号:US11275699

    申请日:2006-01-25

    IPC分类号: A61K31/4745

    摘要: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain sulfonamide or sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

    摘要翻译: 在1位含有磺酰胺或磺酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫反应调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成,并且可用于治疗各种病症,包括病毒性疾病和肿瘤性疾病。

    Treatment for lung cancer
    6.
    发明申请
    Treatment for lung cancer 审中-公开
    治疗肺癌

    公开(公告)号:US20050267145A1

    公开(公告)日:2005-12-01

    申请号:US11141655

    申请日:2005-05-31

    IPC分类号: A61K31/19 A61K31/4745

    CPC分类号: A61K31/19 A61K31/4745

    摘要: The present invention provides methods, pharmaceutical compositions, and pharmaceutical combinations useful for treating lung cancer. Generally, the compositions include a 5-LO inhibitor in an amount effective to inhibit 5-lipoxygenase in an inhalable formulation. In some cases, the formulation may further include an IRM compound. Generally, the pharmaceutical combinations include a 5-LO inhibitor and an IRM compound in an inhalable formulation. Generally, the methods include administering to the subject an inhalable formulation that comprises a 5-lipoxygenase inhibitor having a cLogP of at least about 4.0 in an amount effective for treating lung cancer.

    摘要翻译: 本发明提供了可用于治疗肺癌的方法,药物组合物和药物组合。 通常,组合物包含有效抑制可吸入制剂中的5-脂氧合酶的量的5-LO抑制剂。 在一些情况下,制剂还可以包括IRM化合物。 通常,药物组合包括可吸入制剂中的5-LO抑制剂和IRM化合物。 通常,所述方法包括向受试者施用包含具有至少约4.0的cLogP的5-脂氧合酶抑制剂的可吸入制剂,其量为有效治疗肺癌的量。