公开(公告)号：US5785856A

公开(公告)日：1998-07-28

申请号：US820771

申请日：1997-03-18

申请人： Gary L. Gleave ,  Norman J. Rothe ,  David W. Kemp ,  Bruce E. Richter ,  John L. Ezzell

发明人： Gary L. Gleave ,  Norman J. Rothe ,  David W. Kemp ,  Bruce E. Richter ,  John L. Ezzell

IPC分类号： G01N1/10 ,  B01D11/00 ,  B01D11/02 ,  G01N1/34 ,  G01N1/40 ,  G01N30/00 ,  G01N31/00

CPC分类号： G01N1/34 ,  B01D11/0203 ,  B01J20/043 ,  B01J20/3204 ,  B01J20/3236 ,  G01N30/00 ,  G01N2001/4061 ,  G01N2030/009 ,  Y10T436/255

摘要： An apparatus for automated extraction of an analyte from a sample positioned in a sample containment cell having a fluid passageway structure for communication of an extraction fluid to and from the cavity of the cell. The apparatus includes a loading tray, an oven assembly mounted proximate the loading tray, a fluid communication assembly mounted proximate the tray, a cell manipulation assembly and a controller. The cell manipulation assembly brings an inlet conduit and an outlet conduit of the fluid communication assembly into sealed relationship with the sample containment cell and uses the conduits to pick up and move the cell to and from the cell tray and oven assembly. The fluid communication assembly further causes flow of an extraction fluid into the cell and pressurizes the cell for extraction of an analyte from the sample under elevated temperatures and pressures, which can be under supercritical conditions for supercritical fluid extraction but preferably are below supercritical conditions for solvent extraction. The apparatus and method include a solvent extraction soak, purging of the extracted fluid, flushing with a gas and rinsing so as to avoid contamination of subsequent analyte extractions.

摘要翻译： 一种用于从位于样品容纳细胞中的样品自动提取分析物的装置，所述样品容纳细胞具有流体通道结构，用于将提取流体与细胞的腔连通。 该装置包括装载托盘，靠近装载托盘安装的烤箱组件，靠近托盘安装的流体连通组件，单元操作组件和控制器。 电池操作组件将流体连通组件的入口导管和出口导管与样品容纳单元密封，并使用导管将电池从电池托盘和烘箱组件中取出并移动。 流体连通组件进一步引起提取流体流入细胞并对细胞加压，以在升高的温度和压力下从样品中提取分析物，其可以在超临界条件下进行超临界流体萃取，但优选低于溶剂的超临界条件 萃取。 该设备和方法包括溶剂萃取浸泡，抽出的流体的清洗，用气体冲洗和漂洗，以避免后续分析物提取的污染。

公开(公告)号：US4935145A

公开(公告)日：1990-06-19

申请号：US348240

申请日：1989-05-05

申请人： Hernan J. Cortes ,  Curtis D. Pfeiffer ,  Bruce E. Richter

发明人： Hernan J. Cortes ,  Curtis D. Pfeiffer ,  Bruce E. Richter

IPC分类号： G01N30/02 ,  G01N30/16 ,  G01N30/46 ,  G01N30/88

CPC分类号： G01N30/465 ,  G01N30/88 ,  G01N2030/025 ,  G01N2030/165 ,  G01N30/462

摘要： Apparatus and method for on-line coupled liquid chromatography and gas chromatography analysis includes a retention gap which allows injection of a substantial volume of sample-carrying eluent and concentrates bands, obviating adverse effects on the resolution or peak shape of the components of interest. The retention gap is used to simultaneously receive and vaporize liquid solvent in a manner highly suitable for purposes of gas chromatographically separating solutes of interest dispersed in the liquid chromatography solvent.

摘要翻译： 用于在线耦合液相色谱和气相色谱分析的装置和方法包括保留间隙，其允许注入大量样品携带洗脱液和浓缩物带，消除对感兴趣组分的分辨率或峰形的不利影响。 保留间隙用于以非常适合气相色谱分离分散在液相色谱溶剂中的目的溶质的方式同时接收和蒸发液体溶剂。

公开(公告)号：US5843311A

公开(公告)日：1998-12-01

申请号：US259667

申请日：1994-06-14

申请人： Bruce E. Richter ,  Christopher A. Pohl ,  Nathan L. Porter ,  Brian A. Jones ,  John L. Ezzell ,  Nebojsha Avdalovic

发明人： Bruce E. Richter ,  Christopher A. Pohl ,  Nathan L. Porter ,  Brian A. Jones ,  John L. Ezzell ,  Nebojsha Avdalovic

IPC分类号： G01N31/00 ,  B01D11/02 ,  G01N1/10 ,  G01N1/34 ,  G01N1/40 ,  G01N30/00 ,  B01D11/00

CPC分类号： G01N30/00 ,  B01D11/0203 ,  B01J20/043 ,  B01J20/3204 ,  B01J20/3236 ,  G01N1/34 ,  G01N2001/4061 ,  G01N2030/009 ,  Y10T436/255

摘要： Methods for the solvent extraction of organic analytes from a sample are provided. An organic solvent system is used to extract analytes under elevated temperatures and pressures above 100 psi but below supercritical conditions in short times and with low amounts of solvent. The extracted organic analytes are then removed by flowing a purge fluid through the extraction cell, the cell being maintained at a constant volume throughout the extraction and purging, afterwards the analytes being analyzed.

摘要翻译： 提供了从样品中溶剂萃取有机分析物的方法。 有机溶剂系统用于在高于100psi但在短时间内和低量溶剂下超过临界条件的高温和高压下提取分析物。 然后通过将清洗流体流过萃取池除去提取的有机分析物，在整个萃取和清洗期间，将细胞维持在恒定体积，然后分析被分析物。

公开(公告)号：US5660727A

公开(公告)日：1997-08-26

申请号：US398140

申请日：1995-03-03

申请人： Gary L. Gleave ,  Norman J. Rothe ,  David W. Kemp ,  Bruce E. Richter ,  John L. Ezzell

发明人： Gary L. Gleave ,  Norman J. Rothe ,  David W. Kemp ,  Bruce E. Richter ,  John L. Ezzell

IPC分类号： G01N1/10 ,  B01D11/00 ,  B01D11/02 ,  G01N1/34 ,  G01N1/40 ,  G01N30/00 ,  G01N31/00 ,  B01D17/12 ,  G01N35/02 ,  G01N35/04

CPC分类号： G01N1/34 ,  B01D11/0203 ,  B01J20/043 ,  B01J20/3204 ,  B01J20/3236 ,  G01N30/00 ,  G01N2001/4061 ,  G01N2030/009 ,  Y10T436/255

摘要： An apparatus for automated extraction of an analyte from a sample positioned in a sample containment cell having a fluid passageway structure for communication of an extraction fluid to and from the cavity of the cell. The apparatus includes a loading tray, an oven assembly mounted proximate the loading tray, a fluid communication assembly mounted proximate the tray, a cell manipulation assembly and a controller. The cell manipulation assembly brings an inlet conduit and an outlet conduit of the fluid communication assembly into sealed relationship with the sample containment cell and uses the conduits to pick up and move the cell to and from the cell tray and oven assembly. The fluid communication assembly further causes flow of an extraction fluid into the cell and pressurizes the cell for extraction of an analyte from the sample under elevated temperatures and pressures, which can be under supercritical conditions for supercritical fluid extraction but preferably are below supercritical conditions for solvent extraction. The apparatus and method include a solvent extraction soak, purging of the extracted fluid, flushing with a gas and rinsing so as to avoid contamination of subsequent analyte extractions.

摘要翻译： 一种用于从位于样品容纳细胞中的样品自动提取分析物的装置，所述样品容纳细胞具有流体通道结构，用于将提取流体与细胞的腔连通。 该装置包括装载托盘，靠近装载托盘安装的烤箱组件，靠近托盘安装的流体连通组件，单元操作组件和控制器。 电池操作组件将流体连通组件的入口导管和出口导管与样品容纳单元密封，并使用导管将电池从电池托盘和烘箱组件中取出并移动。 流体连通组件进一步引起提取流体流入细胞并对细胞加压，以在升高的温度和压力下从样品中提取分析物，该温度和压力可以在超临界条件下进行超临界流体萃取，但优选低于溶剂的超临界条件 萃取。 该设备和方法包括溶剂萃取浸泡，抽出的流体的清洗，用气体冲洗和漂洗，以避免后续分析物提取的污染。

公开(公告)号：US5522988A

公开(公告)日：1996-06-04

申请号：US318481

申请日：1994-10-05

申请人： Hernan J. Cortes ,  Curtis D. Pfeiffer ,  Bruce E. Richter

发明人： Hernan J. Cortes ,  Curtis D. Pfeiffer ,  Bruce E. Richter

IPC分类号： G01N30/02 ,  G01N30/16 ,  G01N30/46 ,  B01D15/08

CPC分类号： G01N30/465 ,  G01N2030/025 ,  G01N2030/165 ,  G01N30/462

摘要： Apparatus and method for on-line coupled liquid chromatography and gas chromatography analysis. The system includes a high-volume, liquid vaporizing chamber, or interface capillary tube which allows injection of a substantial volume of sample-carrying eluent and concentrates bands, obviating adverse effects on the resolution or peak shape of the components of interest. The vaporizing chamber is interposed between a packed or wall-coated open tubular capillary liquid chromatographic column and a capillary gas chromatographic column. The capillary liquid chromatographic column permits the use of small volumes of eluent and reduced flow rates.

摘要翻译： 在线耦合液相色谱和气相色谱分析的仪器和方法。 该系统包括大容量的液体蒸发室或接口毛细管，其允许注入大量的样品携带洗脱液和浓缩物带，消除对感兴趣的组分的分辨率或峰形的不利影响。 蒸发室介于填充或壁涂开放的管状毛细管液相色谱柱和毛细管气相色谱柱之间。 毛细管液相色谱柱允许使用少量洗脱液和降低流速。

公开(公告)号：US5271903A

公开(公告)日：1993-12-21

申请号：US591612

申请日：1990-10-02

申请人： Kevin Durst ,  Nathan L. Porter ,  Ross A. Riches ,  Gary L. Gleavae ,  R. Brent Nielsen ,  Bruce E. Richter

发明人： Kevin Durst ,  Nathan L. Porter ,  Ross A. Riches ,  Gary L. Gleavae ,  R. Brent Nielsen ,  Bruce E. Richter

IPC分类号： C07B63/00 ,  B01D11/02 ,  B01L5/00 ,  C07C7/10 ,  C07C15/20 ,  G01N1/00 ,  G01N1/34 ,  G01N30/02 ,  G01N30/06 ,  B01L11/00 ,  B01D11/00

CPC分类号： G01N1/34 ,  B01D11/0203 ,  B01L5/00 ,  G01N2030/062 ,  G01N30/02 ,  G01N35/1079

摘要： An apparatus for receiving chemical compounds carried in a high pressure effluent fluid stream from supercritical fluid extraction. The apparatus includes a heated conduit connected to supercritical fluid extraction device through which an effluent stream flows. The exit port of the heated conduit is located within the airspace of a decompression zone which is free of liquid. A liquid solvent chamber is provided in open communication with the downstream end of the decompression zone into which the effluent stream flows for the recovery of chemical compounds therein.

摘要翻译： 用于从超临界流体萃取中接收在高压流出物流中携带的化合物的装置。 该装置包括连接到超临界流体提取装置的加热导管，流出物流通过该超临界流体提取装置流动。 加热导管的出口位于无液体的减压区的空气区域内。 液体溶剂室设置为与减压区的下游端开放连通，流出物流流入其中用于在其中回收化学化合物。

公开(公告)号：US4793920A

公开(公告)日：1988-12-27

申请号：US111147

申请日：1987-10-20

申请人： Hernan Cortes ,  Curtis D. Pfeiffer ,  Bruce E. Richter ,  Timothy S. Stevens

发明人： Hernan Cortes ,  Curtis D. Pfeiffer ,  Bruce E. Richter ,  Timothy S. Stevens

IPC分类号： G01N30/02 ,  G01N30/56 ,  G01N30/60 ,  B01D15/08

CPC分类号： G01N30/56 ,  G01N2030/565 ,  G01N2030/6008 ,  G01N30/02 ,  G01N30/6004 ,  G01N30/6052

摘要： Porous ceramic plugs are cast in place in chromatographic columns in order to provide supports for chromatographic beds in liquid chromatography devices and restrictors in supercritical fluid chromatographic devices. The supports are cast in place by fusing a silicate containing solution, such as one containing potassium silicate, which has been drawn into the outlet end of the column.

摘要翻译： 多孔陶瓷塞在色谱柱中浇注到位，以便为超临界流体色谱装置中液相色谱仪和限流器中的色谱床提供支持。 通过将已经被吸入柱的出口端的含硅酸盐溶液，例如含有硅酸钾的溶液熔化，从而将载体浇注到位。

公开(公告)号：US5236593A

公开(公告)日：1993-08-17

申请号：US982266

申请日：1992-11-25

申请人： Hernan J. Cortes ,  Curtis D. Pfeiffer ,  Bruce E. Richter

发明人： Hernan J. Cortes ,  Curtis D. Pfeiffer ,  Bruce E. Richter

IPC分类号： G01N30/02 ,  G01N30/16 ,  G01N30/46

CPC分类号： G01N30/465 ,  G01N2030/025 ,  G01N2030/165 ,  G01N30/462

摘要： Apparatus and method for on-line coupled liquid chromatography and gas chromatography analysis. The system includes a high-volume, liquid vaporizing chamber, or interface capillary tube which allows injection of a substantial volume of sample-carrying eluent and concentrates bands, obviating adverse effects on the resolution or peak shape of the components of interest. The vaporizing chamber is interposed between a packed or wall-coated open tubular capillary liquid chromatographic column and a capillary gas chromatographic column. The capillary liquid chromatographic column permits the use of small volumes of eluent and reduced flow rates.

摘要翻译： 在线耦合液相色谱和气相色谱分析的仪器和方法。 该系统包括大容量的液体蒸发室或接口毛细管，其允许注入大量的样品携带洗脱液和浓缩物带，消除对感兴趣的组分的分辨率或峰形的不利影响。 蒸发室介于填充或壁涂开放的管状毛细管液相色谱柱和毛细管气相色谱柱之间。 毛细管液相色谱柱允许使用少量洗脱液和降低流速。