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公开(公告)号：US07928210B2
公开(公告)日：2011-04-19
申请号：US12074538
申请日：2008-03-03
Applicant: Hartmuth C. Kolb , Joseph C. Walsh , Robert M Yeh , Kai Chen , Umesh Gangadharmath , Brian Duclos , Vani P. Mocharla , Farhad Karimi , Henry C. Padgett , Qianwa Liang , Tieming Zhao
Inventor： Hartmuth C. Kolb , Joseph C. Walsh , Robert M Yeh , Kai Chen , Umesh Gangadharmath , Brian Duclos , Vani P. Mocharla , Farhad Karimi , Henry C. Padgett , Qianwa Liang , Tieming Zhao
CPC classification number: C07H19/073 , A61K51/0491 , C07H19/06 , C07H19/067
Abstract: Disclosed herein are novel radiolabeled nucleosides and methods for detecting cellular proliferation in a mammal, the method comprising administrating an effective amount of a radiolabeled nucleoside; the method comprising: a) administering to the mammal a diagnostically effective amount of the nucleoside to the mammal; b) allowing the nucleoside to distribute into the effective tissue; and c) imaging the tissue, wherein an increase in binding of the compound to tissue compared to a normal control level of binding indicates that the mammal is suffering from a disease involving cellular proliferation.
Abstract translation: 本文公开了新型放射性标记核苷和用于检测哺乳动物细胞增殖的方法，该方法包括施用有效量的放射性标记的核苷; 所述方法包括：a）向哺乳动物施用诊断有效量的核苷; b）允许核苷分布到有效组织中; 和c）对所述组织进行成像，其中与正常对照结合水平相比，所述化合物与组织的结合增加指示所述哺乳动物患有涉及细胞增殖的疾病。
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公开(公告)号：US20090016958A1
公开(公告)日：2009-01-15
申请号：US12074538
申请日：2008-03-03
Applicant: Hartmuth C. Kolb , Joseph C. Walsh , Robert M. Yeh , Kai Chen , Umesh Gangadharmath , Brian Duclos , Vani P. Mocharla , Farhad Karimi , Henry C. Padgett , Qianwa Liang , Tieming Zhao
Inventor： Hartmuth C. Kolb , Joseph C. Walsh , Robert M. Yeh , Kai Chen , Umesh Gangadharmath , Brian Duclos , Vani P. Mocharla , Farhad Karimi , Henry C. Padgett , Qianwa Liang , Tieming Zhao
CPC classification number: C07H19/073 , A61K51/0491 , C07H19/06 , C07H19/067
Abstract: Disclosed herein are novel radiolabeled nucleosides and methods for detecting cellular proliferation in a mammal, the method comprising administrating an effective amount of a radiolabeled nucleoside; the method comprising: a) administering to the mammal a diagnostically effective amount of the nucleoside to the mammal; b) allowing the nucleoside to distribute into the effective tissue; and c) imaging the tissue, wherein an increase in binding of the compound to tissue compared to a normal control level of binding indicates that the mammal is suffering from a disease involving cellular proliferation.
Abstract translation: 本文公开了新型放射性标记核苷和用于检测哺乳动物细胞增殖的方法，该方法包括施用有效量的放射性标记的核苷; 所述方法包括：a）向哺乳动物施用诊断有效量的核苷; b）允许核苷分布到有效组织中; 和c）对所述组织进行成像，其中与正常对照结合水平相比，所述化合物与组织的结合增加指示所述哺乳动物患有涉及细胞增殖的疾病。
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3.发明申请公开(公告)号：US20080213175A1
公开(公告)日：2008-09-04
申请号：US11901704
申请日：2007-09-17
Applicant: Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Umesh Gangadharmath , Dhanalakshmi Kasi , Bing Wang , Brian Duclos , Qianwa Liang , Henry Clifton Padgett , Farhad Karimi
Inventor： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Umesh Gangadharmath , Dhanalakshmi Kasi , Bing Wang , Brian Duclos , Qianwa Liang , Henry Clifton Padgett , Farhad Karimi
CPC classification number: C07K7/56
Abstract: The present application is directed to radiolabeled cyclic peptidomimetics, pharmaceutical compositions comprising radiolabeled cyclic peptidomimetics, and methods of using the radiolabeled cyclic peptidomimetics. Such peptidomimetics can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
Abstract translation: 本申请涉及放射性标记的环肽模拟物，包含放射性标记的环肽模拟物的药物组合物，以及使用放射性标记的环肽模拟物的方法。 这种肽模拟物可用于成像研究，例如正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）。
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