公开(公告)号：US20250002486A1

公开(公告)日：2025-01-02

申请号：US18692503

申请日：2022-09-15

Applicant: Boundless Bio, Inc.

Inventor： Anthony B. PINKERTON ,  Jacques MAUGER ,  Yen Pham Hong TRUONG ,  Rachelle Janette ELSDON ,  Stephen Todd MEYER

IPC: C07D417/06 ,  A61K31/428 ,  A61K31/5415 ,  A61K31/542 ,  A61K31/554 ,  A61K45/06 ,  C07D513/04

Abstract: Provided herein are compounds and methods for the treatment of cancer. The methods include administering to a subject in need a therapeutically effective amount of a cyclic sulfonamide RNR inhibitor disclosed herein.

公开(公告)号：US20230026313A1

公开(公告)日：2023-01-26

申请号：US17897667

申请日：2022-08-29

Applicant: Boundless Bio, Inc.

Inventor： Anthony B. PINKERTON ,  Stephen Todd MEYER ,  Jacques MAUGER ,  Yen Pham Hong TRUONG ,  Rachelle Janette ELSDON

IPC: A61K31/497 ,  C07D401/12

Abstract: Provided herein are compounds and methods for the treatment of cancer. The methods include administering to a subject in need a therapeutically effective amount of a Chk1 inhibitor disclosed herein.

公开(公告)号：US20230248728A1

公开(公告)日：2023-08-10

申请号：US18189453

申请日：2023-03-24

Applicant: Boundless Bio, Inc.

Inventor： Christian HASSIG ,  Ryan HANSEN ,  Snezana MILUTINOVIC ,  Jason CHRISTIANSEN ,  Zachary D. HORNBY ,  Sudhir CHOWDHRY ,  Anthony CELESTE ,  Kristen TURNER ,  Deepti WILKINSON

IPC: A61K31/517 ,  A61P35/00 ,  A61K45/06

CPC classification number: A61K31/517 ,  A61P35/00 ,  A61K45/06

Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.

公开(公告)号：US11642345B2

公开(公告)日：2023-05-09

申请号：US18048573

申请日：2022-10-21

Applicant: Boundless Bio, Inc.

Inventor： Christian Hassig ,  Ryan Hansen ,  Snezana Milutinovic ,  Jason Christiansen ,  Zachary Hornby ,  Sudhir Chowdhry ,  Anthony Celeste ,  Kristen Turner ,  Deepti Wilkinson

IPC: A61K31/517 ,  A61P35/00 ,  A61K45/06

CPC classification number: A61K31/517 ,  A61K45/06 ,  A61P35/00

Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.

公开(公告)号：US20240425490A1

公开(公告)日：2024-12-26

申请号：US18692505

申请日：2022-09-15

Applicant: Boundless Bio, Inc.

Inventor： Anthony B. PINKERTON ,  Jacques MAUGER ,  Yen Pham Hong TRUONG ,  Rachelle Janette ELSDON ,  Stephen Todd MEYER

IPC: C07D413/12 ,  A61K9/00 ,  A61K9/48 ,  A61K31/4245 ,  A61K31/437 ,  A61K31/438 ,  A61K31/439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/496 ,  A61K45/06 ,  A61K47/46 ,  C07D271/10 ,  C07D413/14 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D491/107 ,  C07D491/113

Abstract: Provided herein are compounds and methods for the treatment of cancer. The methods include administering to a subject in need a therapeutically effective amount of a sulfamide RNR inhibitor disclosed herein.

公开(公告)号：US20240285614A1

公开(公告)日：2024-08-29

申请号：US18433734

申请日：2024-02-06

Applicant: Boundless Bio, Inc.

Inventor： Anthony B. PINKERTON ,  Jacques MAUGER ,  Yen Pham Hong TRUONG ,  Camille REMEUR ,  Jérôme TOUM ,  Olivier MIRGUET

IPC: A61K31/496 ,  A61K31/404 ,  A61K31/435 ,  A61K31/438 ,  A61K31/454 ,  A61K31/4995 ,  A61K45/06 ,  C07D207/12 ,  C07D209/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/08

CPC classification number: A61K31/496 ,  A61K31/404 ,  A61K31/435 ,  A61K31/438 ,  A61K31/454 ,  A61K31/4995 ,  A61K45/06 ,  C07D207/12 ,  C07D209/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D471/04 ,  C07D471/08 ,  C07D471/10 ,  C07D487/08

Abstract: Provided herein are compounds and methods for the treatment of cancer. The methods include administering to a subject in need a therapeutically effective amount of a cyclic sulfonamide RNR inhibitor disclosed herein.

公开(公告)号：US11547711B2

公开(公告)日：2023-01-10

申请号：US17568434

申请日：2022-01-04

Applicant: Boundless Bio, Inc.

Inventor： Christian Hassig ,  Ryan Hansen ,  Snezana Milutinovic ,  Jason Christiansen ,  Zachary Hornby ,  Sudhir Chowdhry ,  Anthony Celeste ,  Kristen Turner ,  Deepti Wilkinson

IPC: A61K31/517 ,  A61P35/00 ,  A61K45/06

Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.

公开(公告)号：US20240158383A1

公开(公告)日：2024-05-16

申请号：US18547794

申请日：2022-03-01

Applicant: Boundless Bio, Inc.

Inventor： Anthony B. PINKERTON ,  Jacques MAUGER ,  Stephen Todd MEYER

IPC: C07D413/12 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

CPC classification number: C07D413/12 ,  C07D257/04 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12

Abstract: Provided herein are compounds and methods for the treatment of cancer. The methods include administering to a subject in need a therapeutically effective amount of a of RNR inhibitor disclosed herein.

公开(公告)号：US20230272485A1

公开(公告)日：2023-08-31

申请号：US18169797

申请日：2023-02-15

Applicant: Boundless Bio, Inc.

Inventor： Christian HASSIG ,  Ryan HANSEN ,  Snezana MILUTINOVIC ,  Zachary D. HORNBY ,  Sudhir CHOWDHRY ,  Kristen TURNER ,  Deepti WILKINSON ,  Shailaja KASIBHATLA

IPC: C12Q1/6886 ,  A61K31/517 ,  A61K45/06

CPC classification number: C12Q1/6886 ,  A61K31/517 ,  A61K45/06

Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.

公开(公告)号：US11707462B2

公开(公告)日：2023-07-25

申请号：US17897667

申请日：2022-08-29

Applicant: Boundless Bio, Inc.

Inventor： Anthony B. Pinkerton ,  Stephen Todd Meyer ,  Jacques Mauger ,  Yen Pham Hong Truong ,  Rachelle Janette Elsdon

IPC: C07D401/14 ,  C07D403/12 ,  A61K31/497 ,  C07D401/12

CPC classification number: A61K31/497 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

Abstract: Provided herein are compounds and methods for the treatment of cancer. The methods include administering to a subject in need a therapeutically effective amount of a Chk1 inhibitor disclosed herein.