公开(公告)号：US11642345B2

公开(公告)日：2023-05-09

申请号：US18048573

申请日：2022-10-21

Applicant: Boundless Bio, Inc.

Inventor： Christian Hassig ,  Ryan Hansen ,  Snezana Milutinovic ,  Jason Christiansen ,  Zachary Hornby ,  Sudhir Chowdhry ,  Anthony Celeste ,  Kristen Turner ,  Deepti Wilkinson

IPC: A61K31/517 ,  A61P35/00 ,  A61K45/06

CPC classification number: A61K31/517 ,  A61K45/06 ,  A61P35/00

Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.

公开(公告)号：US11547711B2

公开(公告)日：2023-01-10

申请号：US17568434

申请日：2022-01-04

Applicant: Boundless Bio, Inc.

Inventor： Christian Hassig ,  Ryan Hansen ,  Snezana Milutinovic ,  Jason Christiansen ,  Zachary Hornby ,  Sudhir Chowdhry ,  Anthony Celeste ,  Kristen Turner ,  Deepti Wilkinson

IPC: A61K31/517 ,  A61P35/00 ,  A61K45/06

Abstract: Provided herein are methods of treating cancer in a subject, wherein the cancer is extrachromosomal DNA-positive (ecDNA-positive) or therapeutically resistant, the method comprising administering to the subject a therapeutically effective amount of a replication stress (RS) pathway agent alone or in combination with a targeted therapeutic.