公开(公告)号：US20100257617A1

公开(公告)日：2010-10-07

申请号：US11708858

申请日：2007-02-21

Applicant: Chinnaiyan Arul ,  Bharathi Laxman ,  Scott Tomlins ,  Rohit Mera

Inventor： Chinnaiyan Arul ,  Bharathi Laxman ,  Scott Tomlins ,  Rohit Mera

IPC: A01K67/027

CPC classification number: C12Q1/6886 ,  A01K67/0275 ,  A01K2217/072 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/0331 ,  C07K14/82 ,  C07K2319/00 ,  C12N9/6424 ,  C12N9/6445 ,  C12N15/113 ,  C12N2310/11 ,  C12N2310/14 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57434 ,  Y10S435/81

Abstract: The present invention relates to compositions and methods for cancer diagnosis, research and therapy, including but not limited to, cancer markers. In particular, the present invention relates to recurrent gene fusion nucleic acids and transgenic animals comprising recurrent gene fusion nucleic acids.

Abstract translation: 本发明涉及用于癌症诊断，研究和治疗的组合物和方法，包括但不限于癌症标志物。 特别地，本发明涉及复发性基因融合核酸和包含复发性基因融合核酸的转基因动物。

公开(公告)号：US07332290B2

公开(公告)日：2008-02-19

申请号：US10909035

申请日：2004-07-30

Applicant: Mark A. Rubin ,  Arul M. Chinnaiyan ,  Bharathi Laxman ,  Arun Sreekumar

Inventor： Mark A. Rubin ,  Arul M. Chinnaiyan ,  Bharathi Laxman ,  Arun Sreekumar

IPC: G01N33/53

CPC classification number: G01N33/57434 ,  C07K16/3069 ,  C07K16/40 ,  C12Q1/533 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  Y10S435/96 ,  Y10S436/813

Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. The present invention also provides novel markers useful for the diagnosis, characterization, and treatment of prostate cancers. In particular, the present invention provides methods and compositions for the detection of α-methylacyl-CoA racemase (AMACR) in the urine as a marker for prostate cancer detection.

Abstract translation: 本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供与前列腺癌相关的基因表达谱。 本发明还提供了可用于诊断，表征和治疗前列腺癌的新型标志物。 特别地，本发明提供了检测尿中α-甲酰基-CoA消旋酶（AMACR）作为前列腺癌检测标记物的方法和组合物。

公开(公告)号：US20050136493A1

公开(公告)日：2005-06-23

申请号：US10909035

申请日：2004-07-30

Applicant: Mark Rubin ,  Arul Chinnaiyan ,  Bharathi Laxman ,  Arun Sreekumar

Inventor： Mark Rubin ,  Arul Chinnaiyan ,  Bharathi Laxman ,  Arun Sreekumar

IPC: C12N15/09 ,  C12Q1/02 ,  C12Q1/68 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53 ,  G01N33/566 ,  G01N33/574 ,  C07K16/40 ,  C12Q1/48

CPC classification number: G01N33/57434 ,  C07K16/3069 ,  C07K16/40 ,  C12Q1/533 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/158 ,  Y10S435/96 ,  Y10S436/813

Abstract: The present invention relates to compositions and methods for cancer diagnostics, including but not limited to, cancer markers. In particular, the present invention provides gene expression profiles associated with prostate cancers. The present invention also provides novel markers useful for the diagnosis, characterization, and treatment of prostate cancers. In particular, the present invention provides methods and compositions for the use of α-methylacyl-CoA racemase (AMACR) as a marker for prostate cancer detection and prognosis.

Abstract translation: 本发明涉及用于癌症诊断的组合物和方法，包括但不限于癌症标志物。 特别地，本发明提供与前列腺癌相关的基因表达谱。 本发明还提供了可用于诊断，表征和治疗前列腺癌的新型标志物。 特别地，本发明提供了使用α-甲酰基-CoA消旋酶（AMACR）作为前列腺癌检测和预后的标记物的方法和组合物。