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公开(公告)号:US08729246B2
公开(公告)日:2014-05-20
申请号:US13571916
申请日:2012-08-10
申请人: Noshir A. Langrana , David C. Lin , Bernard Yurke
发明人: Noshir A. Langrana , David C. Lin , Bernard Yurke
IPC分类号: C07H21/02
摘要: The present invention provides a composition for selectively delivering an active agent to a portion of an organism. The composition comprises first and second polymer portions, having first and second functional groups attached as a side-chain thereto, respectively. The first and second functional groups form cross-links between the first and second polymer portions. The cross-links are capable of being broken by a substance of the organism, thereby resulting in release of the active agent. The composition provides a novel means for controlling the selective release of the active agent in the organism.
摘要翻译: 本发明提供了一种选择性地将活性剂递送到生物体的一部分的组合物。 该组合物包含第一和第二聚合物部分,分别具有作为其侧链连接的第一和第二官能团。 第一和第二官能团在第一和第二聚合物部分之间形成交联。 交联体能够被生物体的物质破坏,从而导致活性剂的释放。 该组合物提供了控制生物体中活性剂选择性释放的新手段。
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公开(公告)号:US08569042B2
公开(公告)日:2013-10-29
申请号:US11064907
申请日:2005-02-23
申请人: Aref Chowdhury , Hock Min Ng , Bernard Yurke
发明人: Aref Chowdhury , Hock Min Ng , Bernard Yurke
CPC分类号: G02B6/124 , B82Y10/00 , B82Y15/00 , B82Y20/00 , G01N33/553 , G01N33/588
摘要: An apparatus includes a substrate and a plurality of DNA oligomers in contact with a top surface of the substrate. The substrate is a polar ferroelectric or a polar compound semiconductor.
摘要翻译: 一种装置包括底物和与基底的顶表面接触的多个DNA低聚物。 基板是极性铁电体或极性化合物半导体。
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公开(公告)号:US07429858B2
公开(公告)日:2008-09-30
申请号:US11391538
申请日:2006-03-28
申请人: Dennis S. Greywall , Bernard Yurke
发明人: Dennis S. Greywall , Bernard Yurke
IPC分类号: G01R33/02
CPC分类号: G01R33/0283 , G01R33/02 , G01R33/0286
摘要: In one embodiment, an integrated magnetometer has a deformable, electrically conducting beam that is mounted on a substrate and adapted to oscillate with respect to the substrate. When the oscillating beam is exposed to a magnetic field, the magnetic field induces an oscillating electromotive force that generates an oscillating electrical signal along the beam. The magnetometer has a detection circuit that detects this oscillating electrical signal and, based on the results of this detection, determines the magnetic-field strength and/or the magnetic-field gradient.
摘要翻译: 在一个实施例中,集成磁力计具有可变形的导电梁,其安装在基板上并适于相对于基板振荡。 当振荡光束暴露于磁场时,磁场引起振荡电动势,其产生沿着光束的振荡电信号。 磁力计具有检测该振荡电信号的检测电路,并且基于该检测结果确定磁场强度和/或磁场梯度。
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公开(公告)号:US20050213104A1
公开(公告)日:2005-09-29
申请号:US10812164
申请日:2004-03-29
CPC分类号: G01J4/04 , G02B5/3066 , G02B27/28
摘要: A passive optical system substantially simultaneously separates light received at an optical input into three or more output light beams on optical outputs. The output light beams may have intensities that are proportional to intensities of optical projections of the received light onto three or more basis vectors of a tetrahedral basis set of a Stokes space. The system includes either multiple partial polarization splitters or multiple optical interferometers.
摘要翻译: 无源光学系统基本上同时将光输入处接收的光分离成光输出上的三个或更多个输出光束。 输出光束可以具有与接收的光的光学投影的强度成比例的强度,该强度与斯托克斯空间的四面体基础集合的三个或更多个基本向量成比例。 该系统包括多个部分偏振分离器或多个光学干涉仪。
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公开(公告)号:US09914960B2
公开(公告)日:2018-03-13
申请号:US14211076
申请日:2014-03-14
申请人: Jeunghoon Lee , Bernard Yurke , Elton Graugnard , Will Hughes , Bert Huttanus
发明人: Jeunghoon Lee , Bernard Yurke , Elton Graugnard , Will Hughes , Bert Huttanus
IPC分类号: C12Q1/68
CPC分类号: C12Q1/682 , C12Q2525/197 , C12Q2525/301 , C12Q2563/137 , C12Q2563/155 , C12Q2565/113
摘要: The present invention provides compositions and methods for colorimetric detection schemes for detecting a variety of biomolecules. The compositions and methods employ DNA hybridization chain reaction for catalytic aggregation of gold nanoparticles. In this catalytic aggregation scheme, a single target DNA strand triggers the formation of multiple inter-particle linkages in contrast to the single linkage formed in conventional direct aggregation schemes.
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公开(公告)号:US20130202582A1
公开(公告)日:2013-08-08
申请号:US13571916
申请日:2012-08-10
申请人: Noshir Langrana , David Lin , Bernard Yurke
发明人: Noshir Langrana , David Lin , Bernard Yurke
IPC分类号: A61K47/36
摘要: The present invention provides a composition for selectively delivering an active agent to a portion of an organism. The composition comprises first and second polymer portions, having first and second functional groups attached as a side-chain thereto, respectively. The first and second functional groups form cross-links between the first and second polymer portions. The cross-links are capable of being broken by a substance of the organism, thereby resulting in release of the active agent. The composition provides a novel means for controlling the selective release of the active agent in the organism.
摘要翻译: 本发明提供了一种选择性地将活性剂递送到生物体的一部分的组合物。 该组合物包含第一和第二聚合物部分,分别具有作为其侧链连接的第一和第二官能团。 第一和第二官能团在第一和第二聚合物部分之间形成交联。 交联体能够被生物体的物质破坏,从而导致活性剂的释放。 该组合物提供了控制生物体中活性剂选择性释放的新手段。
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公开(公告)号:US07189987B2
公开(公告)日:2007-03-13
申请号:US10405398
申请日:2003-04-02
申请人: Zhenan Bao , Bernard Yurke
发明人: Zhenan Bao , Bernard Yurke
IPC分类号: H01L51/00
CPC分类号: G01N27/4145
摘要: The present invention provides an organic field effect transistor and a method of fabricating the transistor. The transistor includes a semiconductive film comprising organic molecules. Probe molecules capable of binding to target molecules are coupled to an outer surface of the semiconductive film such that the interior of the film being substantially free of the probe molecules.
摘要翻译: 本发明提供一种有机场效应晶体管及其制造方法。 晶体管包括包含有机分子的半导体膜。 能够结合靶分子的探针分子被偶联到半导体膜的外表面,使得膜的内部基本上不含探针分子。
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公开(公告)号:US20060210993A1
公开(公告)日:2006-09-21
申请号:US11064907
申请日:2005-02-23
申请人: Aref Chowdhury , Hock Ng , Bernard Yurke
发明人: Aref Chowdhury , Hock Ng , Bernard Yurke
CPC分类号: G02B6/124 , B82Y10/00 , B82Y15/00 , B82Y20/00 , G01N33/553 , G01N33/588
摘要: An apparatus includes a substrate and a plurality of DNA oligomers in contact with a top surface of the substrate. The substrate is a polar ferroelectric or a polar compound semiconductor.
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9.
公开(公告)号:US20180216158A1
公开(公告)日:2018-08-02
申请号:US15877128
申请日:2018-01-22
申请人: Jeunghoon Lee , Bernard Yurke , Elton Graugnard , Will Hughes , Bert Huttanus
发明人: Jeunghoon Lee , Bernard Yurke , Elton Graugnard , Will Hughes , Bert Huttanus
IPC分类号: C12Q1/682
CPC分类号: C12Q1/682 , C12Q2525/197 , C12Q2525/301 , C12Q2563/137 , C12Q2563/155 , C12Q2565/113
摘要: The present invention provides compositions and methods for colorimetric detection schemes for detecting a variety of biomolecules. The compositions and methods employ DNA hybridization chain reaction for catalytic aggregation of gold nanoparticles. In this catalytic aggregation scheme, a single target DNA strand triggers the formation of multiple inter-particle linkages in contrast to the single linkage formed in conventional direct aggregation schemes.
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公开(公告)号:US20100292402A1
公开(公告)日:2010-11-18
申请号:US12725065
申请日:2010-03-16
申请人: Allen P. Mills, JR. , Bernard Yurke
发明人: Allen P. Mills, JR. , Bernard Yurke
CPC分类号: A61L27/26 , A61L27/52 , C08F265/04 , C08F283/00 , C08F289/00 , C08L51/003 , C12Q1/6876 , C08L2666/02
摘要: The present invention provides a composition comprising a first polymer and a second polymer cross-linked by the association of functional groups attached as side chains to the polymers.
摘要翻译: 本发明提供一种组合物,其包含第一聚合物和通过作为侧链连接的官能团与聚合物缔合而交联的第二聚合物。
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