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公开(公告)号：US20150158929A1
公开(公告)日：2015-06-11
申请号：US14379192
申请日：2012-07-11
Applicant: Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
Inventor： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
IPC: C07K14/755
Abstract: The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
Abstract translation: 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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2.发明授权公开(公告)号：US08716448B2
公开(公告)日：2014-05-06
申请号：US12806005
申请日：2010-08-02
Applicant: Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
Inventor： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
IPC: A61K38/36 , C07K14/745
CPC classification number: C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
Abstract: The present invention relates to compositions comprising factor VII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
Abstract translation: 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VII凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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3.发明授权公开(公告)号：US09062299B2
公开(公告)日：2015-06-23
申请号：US13392511
申请日：2010-08-02
Applicant: Volker Schellenberger , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
Inventor： Volker Schellenberger , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
CPC classification number: C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
Abstract: The present invention relates to compositions comprising factor DC coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
Abstract translation: 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子DC凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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4.发明申请BINDING FUSION PROTEINS, BINDING FUSION PROTEIN-DRUG CONJUGATES, XTEN-DRUG CONJUGATES AND METHODS OF MAKING AND USING SAME 有权结合融合蛋白，结合融合蛋白 - 药物结合物，XTEN-DRUG结合体及其制备和使用方法公开(公告)号：US20130165389A1
公开(公告)日：2013-06-27
申请号：US13631361
申请日：2012-09-28
Applicant: Volker Schellenberger , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Susan E. Alters , Nathan Geething
Inventor： Volker Schellenberger , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Susan E. Alters , Nathan Geething
CPC classification number: C12P21/02 , A61K38/00 , C07K14/00 , C07K14/70521 , C07K14/7155 , C07K14/8125 , C07K16/18 , C07K16/241 , C07K16/244 , C07K16/2809 , C07K16/2863 , C07K16/2878 , C07K16/32 , C07K16/40 , C07K2317/31 , C07K2317/569 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/31 , C07K2319/70 , C07K2319/74 , C12N15/625
Abstract: The present invention relates to binding fusion protein compositions comprising targeting moieties linked to extended recombinant polypeptide (XTEN), binding fusion protein-drug conjugate compositions, and XTEN-drug conjugate compositions, isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of diseases, disorders, and conditions.
Abstract translation: 本发明涉及包含与延伸重组多肽（XTEN）连接的靶向部分，结合融合蛋白 - 药物共轭组合物和XTEN-药物共轭组合物的结合融合蛋白组合物，编码组合物和载体的分离的核酸和含有该重组多肽的宿主细胞 以及使用这些组合物治疗疾病，病症和病症的方法。
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5.发明申请COAGULATION FACTOR VII COMPOSITIONS AND METHODS OF MAKING AND USING SAME 审中-公开凝血因子VII组合物及其制备方法和使用方法公开(公告)号：US20120263701A1
公开(公告)日：2012-10-18
申请号：US13392509
申请日：2010-08-02
Applicant: Volker Schellenberger , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
Inventor： Volker Schellenberger , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
CPC classification number: C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
Abstract: The present invention relates to compositions comprising factor VII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
Abstract translation: 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VII凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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Patent Agency Ranking
公开(公告)号：US20120198079A1
公开(公告)日：2012-08-02
申请号：US13019078
申请日：2011-02-01
Applicant: Benjamin Spink
Inventor： Benjamin Spink
IPC: G06F15/16
CPC classification number: H04L67/02 , H04L67/2876 , H04L69/14
Abstract: One example embodiment includes a system for transmitting data from a source system to a target system over an HTTP network. The system includes a user client, where the user client receives data to transmit from a source system to a target system. The system also includes a source tunnel. The source tunnel is configured to receive the data from the client and break the data into pieces for individual transmission. The source tunnel is also configured to establish a plurality of connections with a target system and transmit the pieces of the plurality on connections.
Abstract translation: 一个示例实施例包括用于通过HTTP网络将数据从源系统传输到目标系统的系统。 该系统包括用户客户端，其中用户客户端接收从源系统传输到目标系统的数据。 该系统还包括源隧道。 源隧道被配置为从客户端接收数据并将数据分割成单独的传输。 源隧道还被配置为与目标系统建立多个连接并且传输多个连接上的片段。
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公开(公告)号：US08673860B2
公开(公告)日：2014-03-18
申请号：US12699761
申请日：2010-02-03
Applicant: Volker Schellenberger , Joshua Silverman , Chia-wel Wang , Benjamin Spink , Willem P. Stemmer , Nathan C. Geething , Wayne To , Jeffrey L. Cleland
Inventor： Volker Schellenberger , Joshua Silverman , Chia-wel Wang , Benjamin Spink , Willem P. Stemmer , Nathan C. Geething , Wayne To , Jeffrey L. Cleland
IPC: A61K38/16
CPC classification number: C07K14/47 , C07K14/001 , C07K14/545 , C07K14/605 , C07K14/61 , C07K14/745 , C07K2319/31 , C07K2319/35 , C12N9/6437 , C12N9/644
Abstract: The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.
Abstract translation: 本发明涉及包含与延伸的重组多肽（XTEN）连接的生物活性蛋白质的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及使用这些组合物治疗葡萄糖相关疾病，代谢疾病 ，凝血障碍和生长激素相关的疾病和病症。
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8.发明申请公开(公告)号：US20120263703A1
公开(公告)日：2012-10-18
申请号：US13392511
申请日：2010-08-02
Applicant: Volker Schellenberger , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
Inventor： Volker Schellenberger , Willem P. Stemmer , Nathan C. Geething , Wayne To , Joshua Silverman , Chia-wei Wang , Benjamin Spink
CPC classification number: C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
Abstract: The present invention relates to compositions comprising factor DC coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
Abstract translation: 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子DC凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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公开(公告)号：US20120178691A1
公开(公告)日：2012-07-12
申请号：US13423031
申请日：2012-03-16
Applicant: Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
Inventor： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Joshua Silverman , Chia-Wei Wang , Benjamin Spink , Nathan Geething
IPC: A61K38/37 , C12N15/62 , C12N15/63 , A61P7/04 , C12N1/19 , C12N1/15 , C12N1/21 , C07K19/00 , C12N5/10
CPC classification number: C07K14/755 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/21 , C07K2319/31 , C07K2319/41 , C07K2319/50 , C07K2319/95
Abstract: The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
Abstract translation: 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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公开(公告)号：US20100239554A1
公开(公告)日：2010-09-23
申请号：US12699761
申请日：2010-02-03
Applicant: Volker Schellenberger , Joshua Silverman , Chia-wel Wang , Benjamin Spink , Willem P. Stemmer , Nathan C. Geething , Wayne To , Jeffrey L. Cleland
Inventor： Volker Schellenberger , Joshua Silverman , Chia-wel Wang , Benjamin Spink , Willem P. Stemmer , Nathan C. Geething , Wayne To , Jeffrey L. Cleland
IPC: A61K38/48 , C07K14/46 , C12N9/64 , C07K14/61 , C07H21/04 , C12N15/63 , C12N1/21 , C12N5/10 , A61P3/10 , A61P3/04 , A61P3/08 , A61P3/06 , A61P7/04 , A61P9/12 , A61P9/10 , A61P5/06 , A61P1/04 , A61P19/02 , A61K38/27 , A61K38/16 , A61K38/26 , A61K38/23 , A61K38/31 , A61P5/22 , A61K38/22 , A61K38/18 , A61K38/36
CPC classification number: C07K14/47 , C07K14/001 , C07K14/545 , C07K14/605 , C07K14/61 , C07K14/745 , C07K2319/31 , C07K2319/35 , C12N9/6437 , C12N9/644
Abstract: The present invention relates to compositions comprising biologically active proteins linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of using such compositions in treatment of glucose-related diseases, metabolic diseases, coagulation disorders, and growth hormone-related disorders and conditions.
Abstract translation: 本发明涉及包含与延伸的重组多肽（XTEN）连接的生物活性蛋白质的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及使用这些组合物治疗葡萄糖相关疾病，代谢疾病 ，凝血障碍和生长激素相关的疾病和病症。
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