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    NANOPARTICLE BASED TUMOR ENDOTHELIAL TARGETING VACCINE
    1.
    发明申请
    NANOPARTICLE BASED TUMOR ENDOTHELIAL TARGETING VACCINE 审中-公开

    公开(公告)号：US20180280444A1

    公开(公告)日：2018-10-04

    申请号：US15619021

    申请日：2017-06-09

    申请人： Batu Biologics, Inc.

    发明人： Samuel C. Wagner ,  Thomas E. Ichim

    IPC分类号： A61K35/44 ,  A61K39/00 ,  A61K31/235

    摘要： Disclosed are methods, compositions of matter, and therapeutic protocols for treatment of cancer by selectively inducing immune responses against blood vessels feeding neoplastic tissue. In one embodiment, placental endothelial cells are stimulated with Phorbol Myristate Acetate (PMA) to induce release of nanoparticles that possess ability to: a) be taken up by antigen presenting; b) presented through direct and indirect presentation to CD4 and CD8 T cells, respectively; and c) utilized to stimulate cytoxic T cellular and humoral responses to selectively inhibit angiogenesis of tumors.

    Integrative Immunotherapy for Cancer Treatment
    4.
    发明申请
    Integrative Immunotherapy for Cancer Treatment 审中-公开

    公开(公告)号：US20200297829A1

    公开(公告)日：2020-09-24

    申请号：US16356892

    申请日：2019-03-18

    申请人： BATU BIOLOGICS, INC.

    发明人： Samuel C. Wagner ,  Thomas E. Ichim

    IPC分类号： A61K39/00 ,  A61P35/00 ,  A61K39/39

    摘要： Disclosed are means, methods, and compositions of matter useful for treatment of cancer through integrated immunotherapy. In one embodiment a synergistic protocol is comprised of: a) establishing a proteomic, genomic, and immunological profile of the patient; b) stimulation of a change in the tumor microenvironment in order to modify the tumor microenvironment to be more conducive to immunotherapy; c) priming the immune system in order to be prepared for immune activation; d) activate vaccination in order to induce antigen specific immune responses; e) induction of damage to the tumor in an immunogenic manner; f) immune focusing by utilization of epitope specific vaccination; and g) boosting the immune response.

    Placental Based Contraceptive Vaccine
    5.
    发明申请
    Placental Based Contraceptive Vaccine 审中-公开

    公开(公告)号：US20190201511A1

    公开(公告)日：2019-07-04

    申请号：US16239346

    申请日：2019-01-03

    申请人： BATU BIOLOGICS, INC.

    发明人： Samuel C. Wagner ,  Thomas E. Ichim ,  Santosh Kesari

    IPC分类号： A61K39/00

    CPC分类号： A61K39/0006 ,  A61K2039/515 ,  A61K2039/55 ,  A61K2039/572 ,  A61K2039/575

    摘要： Disclosed are methods of preventing pregnancy through induction of immunological responses through vaccination with placental extracts and products associated with placentation. In one particular embodiment an immune response is triggered towards pregnancy associated neoangiogenesis through administration of placental endothelial cells capable of triggering immunity. In other embodiments the process of replicating immunological events associated with pregnancy failure are recapitulated by stimulation of immunity to antigens such as VEGFR-1, VEGFR-2, CD105, FGF1-R, Integrin αvβ3, and CD-248.

    GENE EDITED ANTIGEN PRESENTING CELLS
    8.
    发明申请
    GENE EDITED ANTIGEN PRESENTING CELLS 审中-公开

    公开(公告)号：US20170165332A1

    公开(公告)日：2017-06-15

    申请号：US15227772

    申请日：2016-08-03

    申请人： Batu Biologics, Inc.

    发明人： Samuel C. Wagner ,  Thomas E. Ichim

    IPC分类号： A61K39/00

    CPC分类号： A61K39/0008 ,  A61K39/0011 ,  A61K2039/5154 ,  C12N5/0639 ,  C12N2510/00

    摘要： Disclosed are cells, compositions of matter, and protocols, useful for stimulation of antigen-specific immunity or tolerogenesis by gene editing of immune suppressive costimulatory molecules for induction of immune stimulation, and gene editing of immune stimulatory molecules for immune suppression. Provided are means of stimulating immunity to cancer, viral antigens, or bacterial antigens through pulsing, fusing, or administering antigenic compositions to antigen presenting cells that are gene silenced for immune suppressive genes. Provided are means of treating transplant rejection or autoimmunity by gene silencing immune stimulatory genes.

    Generation of Tumor Endothelium Specific Viruses
    10.
    发明申请
    Generation of Tumor Endothelium Specific Viruses 审中-公开

    公开(公告)号：US20190282641A1

    公开(公告)日：2019-09-19

    申请号：US16356803

    申请日：2019-03-18

    申请人： BATU BIOLOGICS, INC.

    发明人： Samuel C. Wagner ,  Thomas E. Ichim

    IPC分类号： A61K35/768 ,  C12N5/095 ,  C12N7/00 ,  A61K35/13 ,  A61K39/00

    摘要： Disclosed are means, methods, and compositions of matter useful for generation of viruses that selectively grow in the tumor endothelium and causes lysis or augmentation of tumor immunity. In one embodiment an oncolytic virus is selectively maintained in cells resembling tumor endothelium under conditions allowing for the oncolytic virus to capture immunogenic entities found on the cells resembling tumor endothelial cells. In another embodiment, the endothelial cells resembling tumor endothelial cells are utilized as a “Trojan horse” for selective delivery of virus into a tumor or tumor microenvironment.