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1.发明申请Imidazole Derivatives as Fructose-1,6-Bisphosphatase Inhibitors and Pharmaceutical Compositions Containing Them 失效咪唑衍生物作为果糖-1,6-二磷酸酶抑制剂和含有它们的药物组合物公开(公告)号：US20080312299A1
公开(公告)日：2008-12-18
申请号：US11997485
申请日：2006-07-19
IPC分类号： A61K31/4178 , A61P3/00 , C07D233/54 , C07D409/02 , C07D405/02 , C07D413/14 , A61K31/4245
CPC分类号： C07D233/64 , C07D495/04
摘要： Imidazole derivatives of formula (I) wherein R1, R2a, R2b, A, V and W are as defined in the description, as inhibitors of fructose-1,6-bisphosphatase, their preparation process and their use in the prevention or treatment of diabetes, and other diseases where the inhibition of gluconeogenesis, control of blood glucose levels, reduction in glycogen stores, or reduction in insulin levels is beneficial and diseases related to the insulin resistance syndrome.
摘要翻译： 式（I）的咪唑衍生物，其中R1，R2a，R2b，A，V和W如说明书中所定义，作为果糖-1,6-二磷酸酶的抑制剂，其制备方法及其在预防或治疗糖尿病中的用途 ，以及其他抑制糖异生，控制血糖水平，糖原储存减少或胰岛素水平降低等疾病，以及与胰岛素抵抗综合征有关的疾病。
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公开(公告)号：US08592370B2
公开(公告)日：2013-11-26
申请号：US13139027
申请日：2009-11-13
申请人： Didier Mesangeau , Daniel Cravo , Annick Audet
发明人： Didier Mesangeau , Daniel Cravo , Annick Audet
CPC分类号： A61K38/28 , A61K31/53 , A61K45/06 , Y10S514/866 , A61K2300/00
摘要： The invention relates to a composition for use as a medicament comprising insulin in combination with at least one compound of formula (I) wherein the radicals R1 to R6 have the meaning according to claim 1, and/or physiologically acceptable salts thereof. Another object of the invention concerns a pharmaceutical composition comprising as active ingredients effective amounts of insulin and at least one compound of formula (I), together with pharmaceutically tolerable adjuvants, for the prophylactic or therapeutic treatment and/or monitoring of physiological and/or pathological conditions that are associated with insulin resistance. The invention also relates to a pharmaceutical package comprising insulin in a first dosage unit and at least one compound of formula (I) in a second dosage unit.
摘要翻译： 本发明涉及一种用作药物的组合物，其包含与至少一种其中基团R 1至R 6具有根据权利要求1的含义的至少一种式（I）化合物和/或其生理上可接受的盐组合的胰岛素。 本发明的另一个目的涉及一种药物组合物，其包含有效量的胰岛素和至少一种式（I）化合物与药学上可耐受的佐剂作为活性成分，用于预防或治疗性治疗和/或监测生理和/或病理学 与胰岛素抵抗有关的病症。 本发明还涉及包含第一剂量单位中的胰岛素和在第二剂量单位中的至少一种式（I）化合物的药物包装。
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3.发明授权Benzimidazoledihydrothiadiazinone derivatives as fructose-1,6-bisphosphatase inhibitors, and pharmaceutical compositions comprising same 失效作为果糖-1,6-二磷酸酶抑制剂的苯并咪唑并二氢噻二酮衍生物和包含其的药物组合物公开(公告)号：US08232272B2
公开(公告)日：2012-07-31
申请号：US12742375
申请日：2008-10-13
申请人： Gerard Botton , Caroline Leriche , Annick Arbellot de Vacqueur , Annick Audet , Johannes Gleitz
发明人： Gerard Botton , Caroline Leriche , Annick Arbellot de Vacqueur , Annick Audet , Johannes Gleitz
IPC分类号： C07D417/04 , C07D417/14 , A61K31/54
CPC分类号： C07D417/14 , C07D417/04
摘要： The present invention relates to novel benzimidazole-dihydrothiadiazinone derivatives as fructose-1,6-bisphosphatase inhibitors, to processes for the preparation thereof and to the use thereof in therapy, especially for the treatment of diabetes.
摘要翻译： 本发明涉及作为果糖-1,6-二磷酸酶抑制剂的新的苯并咪唑 - 二氢噻二酮酮衍生物，其制备方法及其在治疗中的用途，特别是用于治疗糖尿病。
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4.发明授权Imidazole derivatives as fructose-1,6-bisphosphatase inhibitors and pharmaceutical compositions containing them 失效作为果糖-1,6-二磷酸酶抑制剂的咪唑衍生物和含有它们的药物组合物公开(公告)号：US08673955B2
公开(公告)日：2014-03-18
申请号：US11997485
申请日：2006-07-19
IPC分类号： A61K31/4439 , A61K31/4245 , A61K31/4178 , A61K31/4164 , C07D413/12 , C07D409/04 , C07D413/14 , C07D233/64
CPC分类号： C07D233/64 , C07D495/04
摘要： Imidazole derivatives of formula (I): wherein R1, R2a, R2b, A, V and W are as defined in the description, as inhibitors of fructose-1,6-bisphosphatase, their preparation process and their use in the prevention or treatment of diabetes, and other diseases where the inhibition of gluconeogenesis, control of blood glucose levels, reduction in glycogen stores, or reduction in insulin levels is beneficial and diseases related to the insulin resistance syndrome.
摘要翻译： 式（I）的咪唑衍生物：其中R1，R2a，R2b，A，V和W如说明书中所定义，作为果糖-1,6-二磷酸酶的抑制剂，其制备方法及其在预防或治疗中的用途 糖尿病和其他疾病，其中糖异生抑制，血糖水平的控制，糖原储备的减少或胰岛素水平的降低是有益的，以及与胰岛素抵抗综合征相关的疾病。
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5.发明申请COMBINATION OF INSULIN WITH TRIAZINE DERIVATIVES AND ITS USE FOR TREATING DIABETES 有权胰岛素与TRIAZINE衍生物的组合及其用于治疗糖尿病公开(公告)号：US20110306543A1
公开(公告)日：2011-12-15
申请号：US13139027
申请日：2009-11-13
申请人： Didier Mesangeau , Daniel Cravo , Annick Audet
发明人： Didier Mesangeau , Daniel Cravo , Annick Audet
CPC分类号： A61K38/28 , A61K31/53 , A61K45/06 , Y10S514/866 , A61K2300/00
摘要： The invention relates to a composition for use as a medicament comprising insulin in combination with at least one compound of formula (I) wherein the radicals R1 to R6 have the meaning according to claim 1, and/or physiologically acceptable salts thereof. Another object of the invention concerns a pharmaceutical composition comprising as active ingredients effective amounts of insulin and at least one compound of formula (I), together with pharmaceutically tolerable adjuvants, for the prophylactic or therapeutic treatment and/or monitoring of physiological and/or pathological conditions that are associated with insulin resistance. The invention also relates to a pharmaceutical package comprising insulin in a first dosage unit and at least one compound of formula (I) in a second dosage unit.
摘要翻译： 本发明涉及一种用作药物的组合物，其包含与至少一种其中基团R 1至R 6具有根据权利要求1的含义的至少一种式（I）化合物和/或其生理上可接受的盐组合的胰岛素。 本发明的另一个目的涉及一种药物组合物，其包含有效量的胰岛素和至少一种式（I）化合物与药学上可耐受的佐剂作为活性成分，用于预防或治疗性治疗和/或监测生理和/或病理学 与胰岛素抵抗有关的病症。 本发明还涉及包含第一剂量单位中的胰岛素和在第二剂量单位中的至少一种式（I）化合物的药物包装。
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6.发明申请NOVEL BENZIMIDAZOLEDIHYDROTHIADIAZINONE DERIVATIVES AS FRUCTOSE-1,6-BISPHOSPHATASE INHIBITORS, AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME 失效新颖的苯并咪唑烷基二氢化茚二酮衍生物作为纤维-1,6-双磷酸酶抑制剂和包含其的药物组合物公开(公告)号：US20100286129A1
公开(公告)日：2010-11-11
申请号：US12742375
申请日：2008-10-13
申请人： Gerard Botton , Caroline Leriche , Annick Arbellot De Vacqueur , Annick Audet , Johannes Gleitz
发明人： Gerard Botton , Caroline Leriche , Annick Arbellot De Vacqueur , Annick Audet , Johannes Gleitz
IPC分类号： A61K31/549 , C07D285/18 , A61P3/00 , A61P13/12 , A61P25/00 , A61P27/02 , A61P9/10 , A61P9/12
CPC分类号： C07D417/14 , C07D417/04
摘要： The present invention relates to novel benzimidazole-dihydrothiadiazinone derivatives as fructose-1,6-bisphosphatase inhibitors, to processes for the preparation thereof and to the use thereof in therapy, especially for the treatment of diabetes.
摘要翻译： 本发明涉及作为果糖-1,6-二磷酸酶抑制剂的新的苯并咪唑 - 二氢噻二酮酮衍生物，其制备方法及其在治疗中的用途，特别是用于治疗糖尿病。
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