公开(公告)号：US09314515B2

公开(公告)日：2016-04-19

申请号：US12989233

申请日：2009-04-22

Applicant: Anita Grigoriadis ,  Otavia L. Caballero ,  Andrew John George Simpson

Inventor： Anita Grigoriadis ,  Otavia L. Caballero ,  Andrew John George Simpson

IPC: A61K38/02 ,  A61K38/17 ,  A61K39/00 ,  C07K14/47 ,  G01N33/574 ,  G01N33/74

CPC classification number: A61K39/0011 ,  C07K14/4748 ,  G01N33/57415 ,  G01N33/743 ,  G01N2333/723

Abstract: Treatments for estrogen receptor and progesterone receptor negative breast cancer or estrogen receptor, progesterone receptor and c-erbB2 negative (triple negative) breast cancer are provided.

Abstract translation: 提供雌激素受体和孕激素受体阴性乳腺癌或雌激素受体，孕酮受体和c-erbB2阴性（三阴性）乳腺癌的治疗。

公开(公告)号：US08321143B2

公开(公告)日：2012-11-27

申请号：US12350945

申请日：2009-01-08

Applicant: Miriam Tendler ,  Richard Charles Garrat ,  Naftale Katz ,  Andrew John George Simpson ,  Frank Jefferson Alarcon de Barrientos ,  Monica Magno Vilar ,  Marilia Sirianni dos Santo Almeida

Inventor： Miriam Tendler ,  Richard Charles Garrat ,  Naftale Katz ,  Andrew John George Simpson ,  Frank Jefferson Alarcon de Barrientos ,  Monica Magno Vilar ,  Marilia Sirianni dos Santo Almeida

IPC: G06F19/00 ,  A61K39/00 ,  A61K38/00 ,  C07K2/00

CPC classification number: A61K39/0003 ,  A61K39/00 ,  C07K14/4354 ,  C07K14/43559 ,  C07K2319/00 ,  G01N33/6893 ,  Y02A50/423

Abstract: The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (Sm14) or related FABPs (Fatty Acid Binding Proteins), the peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic composition and diagnostic kit using peptide fragments.

Abstract translation: 本发明涉及具有与曼氏男性（Sm14）或相关FABP（脂肪酸结合蛋白）的14kDa蛋白质的特定部分的特定部分的氨基酸序列具有一个或多个共有和/或相似氨基酸序列的肽片段， 肽片段用作分子的连续或不连续表位区域或模拟其生物学活性。 更具体地，本发明涉及使用肽片段构建活性肽片段，肽片段，免疫原性组合物和诊断试剂盒的方法。

公开(公告)号：US20110150935A1

公开(公告)日：2011-06-23

申请号：US12989233

申请日：2009-04-22

Applicant: Anita Grigoriadis ,  Otavia L. Caballero ,  Andrew John George Simpson

Inventor： Anita Grigoriadis ,  Otavia L. Caballero ,  Andrew John George Simpson

IPC: A61K39/00 ,  G01N33/574 ,  A61P35/00

CPC classification number: A61K39/0011 ,  C07K14/4748 ,  G01N33/57415 ,  G01N33/743 ,  G01N2333/723

Abstract: Treatments for estrogen receptor and progesterone receptor negative breast cancer or estrogen receptor, progesterone receptor and c-erbB2 negative (triple negative) breast cancer are provided.

Abstract translation: 提供雌激素受体和孕激素受体阴性乳腺癌或雌激素受体，孕酮受体和c-erbB2阴性（三阴性）乳腺癌的治疗。

公开(公告)号：US20110082185A1

公开(公告)日：2011-04-07

申请号：US12678535

申请日：2008-09-16

Applicant: Otavia L. Caballero ,  Tzeela Cohen ,  Andrew John George Simpson

Inventor： Otavia L. Caballero ,  Tzeela Cohen ,  Andrew John George Simpson

IPC: A61K31/7088 ,  C07H21/02 ,  C12N5/02 ,  A61P35/00

CPC classification number: C12N15/113 ,  C12N2310/14

Abstract: The invention relates to methods, formulations and kits useful for inhibiting cancer cell viability, invasion, or migration.

Abstract translation: 本发明涉及可用于抑制癌细胞活力，侵袭或迁移的方法，制剂和试剂盒。

公开(公告)号：US20090312522A1

公开(公告)日：2009-12-17

申请号：US12350945

申请日：2009-01-08

Applicant: Miriam Tendler ,  Richard Charles Garrat ,  Naftale Katz ,  Andrew John George Simpson ,  Frank Jefferson Alarcon de Barrientos ,  Monica Magno Vilar ,  Marilia Sirianni dos Santo Almeida

Inventor： Miriam Tendler ,  Richard Charles Garrat ,  Naftale Katz ,  Andrew John George Simpson ,  Frank Jefferson Alarcon de Barrientos ,  Monica Magno Vilar ,  Marilia Sirianni dos Santo Almeida

IPC: C07K1/00

CPC classification number: A61K39/0003 ,  A61K39/00 ,  C07K14/4354 ,  C07K14/43559 ,  C07K2319/00 ,  G01N33/6893 ,  Y02A50/423

Abstract: The present invention relates to peptide fragments which have one or more shared and/or similar amino acid sequences to amino acid sequences of specific portions of the 14 kDa protein of S. mansoni (Sm14) or related FABPs (Fatty Acid Binding Proteins), the said peptide fragments functioning as continuous or discontinuous epitopic regions of the molecule or mimicking its biological activity. More particularly, the present invention relates to a method for constructing active peptide fragments, peptide fragments, immunogenic composition and diagnostic kit using said peptide fragments.

Abstract translation: 本发明涉及具有与曼氏男性（Sm14）或相关FABP（脂肪酸结合蛋白）的14kDa蛋白质的特定部分的特定部分的氨基酸序列具有一个或多个共有和/或相似氨基酸序列的肽片段， 所述肽片段用作分子的连续或不连续表位区域或模拟其生物学活性。 更具体地，本发明涉及使用所述肽片段构建活性肽片段，肽片段，免疫原性组合物和诊断试剂盒的方法。