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1.发明授权公开(公告)号：US07158226B2
公开(公告)日：2007-01-02
申请号：US10470154
申请日：2002-01-10
申请人： Andreas Gfrörer , Josef Atzler
发明人： Andreas Gfrörer , Josef Atzler
IPC分类号： G01J3/30
CPC分类号： B01L3/50855 , B01L9/06 , G01N21/64 , G02B21/16
摘要： An optical system and method of exciting and measuring fluorescence on or in samples treated using fluorescent pigments using such an optical system having at least one first laser (1); a mirror (4); a deflection element (7); an optic (8); and a unit (10), which includes mirror (4) and optic (8) mounted fixed in relation to one another. The unit (10) is positioned so it is linearly movable back and forth along the optical axis (5) and is mechanically connected to an oscillating linear drive (11). The optic (8) additionally acts as a collimator and the mirror (4) additionally acts to deflect the collimated light (12) parallel to the optical axis (5).
摘要翻译： 使用具有至少一个第一激光器（1）的光学系统激发和测量使用荧光颜料处理的样品中的荧光的光学系统和方法; 镜子（4）; 偏转元件（7）; 光学（8）; 以及包括相对于彼此固定的镜子（4）和光学装置（8）的单元（10）。 单元（10）被定位成使其能够沿光轴（5）前后移动并机械连接到振荡线性驱动器（11）。 光学元件（8）另外用作准直器，反射镜（4）还用于使准直光（12）平行于光轴（5）偏转。
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公开(公告)号：US08222615B2
公开(公告)日：2012-07-17
申请号：US12666035
申请日：2009-02-13
IPC分类号： G01J1/58
CPC分类号： G02B21/26 , G01N21/278 , G01N21/6458 , G01N2021/6419 , G01N2201/104 , G01N2201/11 , G02B21/0076
摘要： Method has laser scanner for pixel-precise imaging of fluorescent samples having fluorescent dyes. The scanner has sample table, laser and first optical system providing laser beam for exciting the samples, scanner head with deflecting element for scanning sample, first lens, second optical system for forwarding emission beams triggered by the laser beam and deflected by first lens and deflecting element to a detector, position encoder emitting position signals indicating location of the scanner head, electronic element for filtering the detector signals with a time constant and an A/D converter for digitizing the filtered detector signals. The filtered detector signals and the position encoder signals are acquired independently, in parallel and continuously by a computer and are related to a common time base, the A/D conversion being carried out often so that each pixel of an image is always assigned more than one data point.
摘要翻译： 方法具有用于具有荧光染料的荧光样品的像素精确成像的激光扫描仪。 扫描仪具有样品台，激光和第一光学系统，提供用于激发样品的激光束，扫描头具有用于扫描样品的偏转元件，第一透镜，用于转发由激光束触发并由第一透镜偏转的发射光束的第二光学系统 发送位置信号的位置编码器，用于指示扫描仪头部的位置，用于对时间常数进行检测器信号的滤波的电子元件和用于数字化滤波的检测器信号的A / D转换器。 经滤波的检测器信号和位置编码器信号由计算机并行并连续地获取并且与公共时基相关，经常执行A / D转换，使得图像的每个像素总是被分配多于 一个数据点。
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公开(公告)号：US07777200B2
公开(公告)日：2010-08-17
申请号：US12252748
申请日：2008-10-16
IPC分类号： G01N21/64
CPC分类号： G02B21/0076 , G02B5/04 , G02B26/105 , G02B27/141
摘要： A laser scanner apparatus images and/or measures a fluorescent sample on a moveable table. At least one laser and an optical system provide two laser beams at differing wavelengths parallel to the fluorescent sample. A moveable wedge-shaped dichroic mirror deflects the laser beams through an objective toward the sample causing spatial separation of the focal points and two non-parallel emission beams. The emission beams are guided through an optical system to two detectors.
摘要翻译： 激光扫描仪装置在可移动台上成像和/或测量荧光样品。 至少一个激光器和光学系统提供与荧光样品平行的不同波长的两个激光束。 可移动的楔形分色镜使激光束通过物镜朝向样品偏转，导致焦点和两个非平行发射光束的空间分离。 发射光束通过光学系统被引导到两个检测器。
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4.发明授权Optical system and method for exciting and measuring fluorescence on or in samples treated with fluorescent pigments 有权用于激发和测量用荧光颜料处理的样品中的荧光的光学系统和方法公开(公告)号：US07355710B2
公开(公告)日：2008-04-08
申请号：US11559483
申请日：2006-11-14
申请人： Andreas Gfrörer , Josef Atzler
发明人： Andreas Gfrörer , Josef Atzler
IPC分类号： G01N21/25
CPC分类号： B01L3/50855 , B01L9/06 , G01N21/64 , G02B21/16
摘要： An optical system for exciting and measuring fluorescence of samples has a first laser; a deflection element; a mirror; and an optic fixed in relation to one another. A unit is linearly movable back and forth along the optical axis and is mechanically connected to an oscillating linear drive. The optic acts as a collimator and the mirror acts to deflect the collimated light diametrically opposite to the bundled light of the laser. A table for receiving sample holders for samples; an optical arrangement for imaging a second focal point; an aperture plate in the second focal point; a first spectral filter; and a first detector are parts of the optical system and a focusing beam of the light emitted by the laser and is deflected by the deflection element toward the mirror.
摘要翻译： 用于激发和测量样品荧光的光学系统具有第一激光器; 偏转元件; 一面镜子; 和相对于彼此固定的光学元件。 一个单元可以沿光轴前后移动并机械地连接到振荡线性驱动器上。 光学器件用作准直器，并且反射镜用于使与激光束的光束径向相反的准直光偏转。 用于接收样品的样品架的表格; 用于对第二焦点进行成像的光学装置; 第二焦点中的孔板; 第一光谱滤波器; 并且第一检测器是光学系统的一部分和由激光器发射的光的聚焦光束，并且被偏转元件偏转到反射镜。
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公开(公告)号：US08149505B2
公开(公告)日：2012-04-03
申请号：US12191137
申请日：2008-08-13
IPC分类号： G02B21/26
CPC分类号： G01N35/00029 , G01N15/1475 , G01N21/6458 , G02B21/0076 , G02B21/26 , G02B21/34 , Y10T436/112499
摘要： A laser scanner device (1) for imaging and/or measuring fluorescent samples located on slides and treated using fluorescent pigments includes a sample table (2) defining a sample plane (49) and a motorized transport device (3) for moving a slide from a storage unit (4) to the sample table (2) and back. The storage unit (4) includes one sample part (7) for sample slides (8) and one test part (9) for test slides (10), each having at least one depository (6) and being accessible during the operation of the laser scanner device (1) for the transport device (3). The test part (9) is implemented separately from the sample part (7) and as a test part magazine (9′) that is permanently connected to the laser scanner device (1) for one or more test slides (10).
摘要翻译： 用于对位于载玻片上并使用荧光颜料处理的荧光样品进行成像和/或测量的激光扫描仪装置（1）包括限定样品平面（49）的样品台（2）和用于将载玻片从 存储单元（4）到样品台（2）并返回。 存储单元（4）包括用于样品载玻片（8）的一个样本部分（7）和用于测试滑块（10）的一个测试部分（9），每个具有至少一个托盘（6）并且在操作期间可访问 用于输送装置（3）的激光扫描装置（1）。 测试部件（9）与样品部分（7）分开实现，并且作为一个测试部件（9'）被固定地连接到用于一个或多个试验滑块（10）的激光扫描装置（1）。
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公开(公告)号：US20110006219A1
公开(公告)日：2011-01-13
申请号：US12666035
申请日：2009-02-13
IPC分类号： G01T1/10
CPC分类号： G02B21/26 , G01N21/278 , G01N21/6458 , G01N2021/6419 , G01N2201/104 , G01N2201/11 , G02B21/0076
摘要： The invention relates to a data acquisition method using a laser scanner for the pixel-precise imaging of fluorescent samples which are on object carriers and have been treated with fluorescent dyes. Such a laser scanner comprises a sample table; at least one laser and a first optical system for providing at least one laser beam for exciting the fluorescent samples; a scanner head (50) having an optical deflecting element for scanning this sample in at least one direction of movement (75); a first lens; a second optical system for forwarding emission beams, which are triggered by the laser beams on the sample and are deflected by the first lens and the deflecting element, to at least one detector; a position encoder (91) which emits position encoder signals (92) which indicate the instantaneous location of the scanner head (50) in relation to a zero point; an electronic element for filtering the detector signals (93) with a defined time constant; and an A/D converter for digitizing the filtered detector signals (93). The data acquisition method according to the invention is characterized in that the filtered detector signals (93) from the A/D converter and the position encoder signals (92) are acquired independently, in a parallel manner and continuously by a computer unit or a controller (40) and are related to a common time base (94), wherein the A/D conversion is carried out so often that each pixel (95) of an image is always assigned more than one data point of the A/D converter.
摘要翻译： 本发明涉及一种使用激光扫描仪进行像素精确成像的数据采集方法，其中荧光样品位于物体载体上并用荧光染料处理。 这种激光扫描器包括样品台; 至少一个激光器和第一光学系统，用于提供用于激发荧光样品的至少一个激光束; 扫描头（50）具有用于在至少一个运动方向（75）扫描该样品的光学偏转元件; 第一个镜头; 用于转发发射光束的第二光学系统，其由样品上的激光束触发并被第一透镜和偏转元件偏转到至少一个检测器; 位置编码器（91），其发射指示扫描器头（50）相对于零点的瞬时位置的位置编码器信号（92） 用于以确定的时间常数对检测器信号（93）进行滤波的电子元件; 以及用于数字化滤波的检测器信号（93）的A / D转换器。 根据本发明的数据获取方法的特征在于，来自A / D转换器的滤波检测器信号（93）和位置编码器信号（92）以并行方式独立地获取并且由计算机单元或控制器 （40）并且与公共时基（94）相关，其中所述A / D转换经常被执行，使得图像的每个像素（95）总是被分配多个A / D转换器的一个数据点。
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公开(公告)号：US07425311B2
公开(公告)日：2008-09-16
申请号：US10465429
申请日：2003-06-18
申请人： Andreas Gfrörer , Josef Grassl , Wolfgang Streit
发明人： Andreas Gfrörer , Josef Grassl , Wolfgang Streit
CPC分类号： B01L3/50855 , B01F5/10 , B01F11/0071 , B01F13/0059 , B01F15/00123 , B01F15/00318 , B01F15/00396 , B01F15/0244 , B01F2215/0037 , B01F2215/0073 , B01L3/5027 , B01L9/06 , B01L2200/0689 , B01L2300/0636 , B01L2300/0822 , B01L2300/0877 , B33Y80/00
摘要： A holding device for at least one object carrier, the object carrier being suitable to receive one or more organic and/or inorganic samples and comprising materials such as glass, plastic, silicon, pyrolytic graphite, and/or metal, this holding device being configured to be gripped by grippers of a robot. The holding device comprising two essentially parallel lengthwise walls and two essentially parallel transverse walls which extend substantially at right angles from the lengthwise walls. Holding devices according to preferred embodiments are constructed in a frame shape, wherein the lengthwise and transverse walls define a frame surrounding at least one opening which completely transverses the device. Holding devices according to further embodiments are constructed a plate shape, in that the region between the lengthwise walls and transverse walls is implemented as a carrying surface. All embodiments comprising gripping surfaces on the external surface profile of the lengthwise and transverse walls.
摘要翻译： 一种用于至少一个物体载体的保持装置，所述物体载体适于接收一种或多种有机和/或无机样品并且包括诸如玻璃，塑料，硅，热解石墨和/或金属的材料，该保持装置被配置 被机器人的夹具夹住。 保持装置包括两个基本上平行的纵向壁和两个基本上平行的横向壁，其从纵向壁基本上以直角延伸。 根据优选实施例的保持装置被构造成框架形状，其中纵向和横向壁限定围绕完全横穿装置的至少一个开口的框架。 根据其他实施例的保持装置被构造为板形，其中纵向壁和横向壁之间的区域被实现为承载表面。 所有实施例包括在纵向和横向壁的外表面轮廓上抓握表面。
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