公开(公告)号：US20120135007A1

公开(公告)日：2012-05-31

申请号：US13265252

申请日：2010-04-27

申请人： Yaron Ilan ,  Gadi Lalazer ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

发明人： Yaron Ilan ,  Gadi Lalazer ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

IPC分类号： A61K39/395 ,  A61P3/06 ,  A61P3/08 ,  A61P1/16

CPC分类号： A61K39/39508 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/04 ,  C07K16/1232 ,  C07K16/26 ,  C07K2317/12

摘要： The invention relates to the use of preparations enriched with anti LPS antibodies, such as those derived from mammalian colostrum or avian eggs, and optionally further antibodies against disease-associated antigens, colostrums, milk or milk product component/s and any adjuvants for treating, delaying or preventing the progression of a pathologic disorder such as chronic liver disease, cirrhosis and any complication or disorder associated therewith. The invention further relates to combined compositions comprising a combination of anti-LPS enriched antibody preparations and antibodies recognizing at least one antigen specific for a pathologic disorder and uses thereof in the treatment of immune-related disorders.

摘要翻译： 本发明涉及富含抗LPS抗体的制剂的使用，例如衍生自哺乳动物初乳或禽卵的那些制剂，以及任选的抗疾病相关抗原，初乳，乳或乳制品组分的任何其它抗体以及任何用于治疗， 延缓或预防慢性肝病，肝硬化以及与之相关的任何并发症或紊乱等病理疾病的进展。 本发明还涉及组合的组合物，其包含抗LPS富集的抗体制剂和识别至少一种对病理学病症特异性的抗原的抗体的组合及其在治疗免疫相关疾病中的用途。

公开(公告)号：US20130224216A1

公开(公告)日：2013-08-29

申请号：US13817414

申请日：2011-08-17

申请人： Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

发明人： Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

IPC分类号： A61K39/40

CPC分类号： A61K39/40 ,  A61K2039/505 ,  C07K16/1203 ,  C07K2317/12

摘要： Methods and compositions for treating conditions including liver dysfunction, e.g., associated with fatty liver; glucose intolerance; and others, by administering compositions comprising anti-LPS immunoglobulin enriched colostrum preparations.

摘要翻译： 用于治疗包括肝功能障碍的病症的方法和组合物，例如与脂肪肝相关; 葡萄糖不耐症; 和其他，通过施用包含抗LPS免疫球蛋白的初乳制剂的组合物。

公开(公告)号：US09943597B2

公开(公告)日：2018-04-17

申请号：US13817414

申请日：2011-08-17

申请人： Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

发明人： Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

IPC分类号： A61K39/395 ,  A61K39/40 ,  C07K16/12 ,  A61K39/00

CPC分类号： A61K39/40 ,  A61K2039/505 ,  C07K16/1203 ,  C07K2317/12

摘要： Methods and compositions for treating conditions including liver dysfunction, e.g., associated with fatty liver; glucose intolerance; and others, by administering compositions comprising anti-LPS immunoglobulin enriched colostrum preparations.

公开(公告)号：US10117930B2

公开(公告)日：2018-11-06

申请号：US13265252

申请日：2010-04-27

申请人： Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

发明人： Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

IPC分类号： A61K39/40 ,  A61K39/395 ,  C07K16/04 ,  C07K16/12 ,  C07K16/26 ,  A61K39/00

摘要： The invention relates to the use of preparations enriched with anti LPS antibodies, such as those derived from mammalian colostrum or avian eggs, and optionally further antibodies against disease-associated antigens, colostrums, milk or milk product component/s and any adjuvants for treating, delaying or preventing the progression of a pathologic disorder such as chronic liver disease, cirrhosis and any complication or disorder associated therewith. The invention further relates to combined compositions comprising a combination of anti-LPS enriched antibody preparations and antibodies recognizing at least one antigen specific for a pathologic disorder and uses thereof in the treatment of immune-related disorders.

公开(公告)号：US20110200610A1

公开(公告)日：2011-08-18

申请号：US12879129

申请日：2010-09-10

申请人： Yaron ILAN ,  Gadi LALAZAR ,  Ami Ben YA'ACOV ,  Tomer ADAR

发明人： Yaron ILAN ,  Gadi LALAZAR ,  Ami Ben YA'ACOV ,  Tomer ADAR

IPC分类号： A61K39/395 ,  A61P3/10 ,  A61P1/16 ,  C07K16/26

CPC分类号： C07K16/26 ,  A61K39/395 ,  A61K2039/55588 ,  A61K2039/57 ,  A61K2300/00

摘要： The present invention relates to immunomodulatory compositions comprising mammalian colostrum-derived immunoglobulin preparation and optionally further colostrums, milk or milk product component/s and any adjuvants for treating immune-related disorders. More specifically, the invention provides compositions comprising colostrum-derived anti-insulin immunoglobulin preparations for the treatment of Metabolic Syndrome. The invention further provides methods and uses of the immunomodulatory compositions for an active or passive immunization in a disease-antigen specific or non specific manner.

摘要翻译： 本发明涉及免疫调节组合物，其包含哺乳动物初乳衍生的免疫球蛋白制备物和任选的另外的初乳，乳或乳制品成分和用于治疗免疫相关病症的任何佐剂。 更具体地，本发明提供了包含用于治疗代谢综合征的初乳衍生的抗胰岛素免疫球蛋白制剂的组合物。 本发明还提供免疫调节组合物在疾病 - 抗原特异性或非特异性方式中的主动或被动免疫的方法和用途。

公开(公告)号：US20120148547A1

公开(公告)日：2012-06-14

申请号：US13391005

申请日：2010-08-31

申请人： Yaron Ilan ,  Meir Mizrahi ,  Ami Ben-Ya'acov

发明人： Yaron Ilan ,  Meir Mizrahi ,  Ami Ben-Ya'acov

IPC分类号： A61K31/7032 ,  A61K35/12 ,  A61P9/10 ,  A61P29/00 ,  A61P1/16

CPC分类号： A61K31/355 ,  A61K31/167 ,  A61K31/7028 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to combined compositions comprising a combination of at least one natural or synthetic beta-glycolipid and at least one tocopherol (vitamin E). The invention further provides methods and kits using said combined compositions for treating and preventing hepatic disorders, specifically, liver insult cause by hepatotoxic drugs or caused by any one of infectious, metabolic, toxic, immune, or perfusion or blood flow related hepatic injury.

摘要翻译： 本发明涉及包含至少一种天然或合成β-糖脂与至少一种生育酚（维生素E）的组合的组合组合物。 本发明还提供了使用所述组合组合物治疗和预防肝脏疾病，特别是由肝毒性药物引起的肝脏损伤或由感染性，代谢性，毒性，免疫或灌注或与血流相关的肝损伤中的任何一种引起的肝组织损伤的方法和试剂盒。