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1.发明授权2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors 失效可用作一氧化氮合酶抑制剂的2-氨基-2-烷基-4-己烯酸和己炔酸衍生物公开(公告)号：US07005450B2
公开(公告)日：2006-02-28
申请号：US10819853
申请日：2004-04-07
申请人： Richard C. Durley , James Sikorski , Donald W. Hansen, Jr. , Michelle A. Promo , Ronald Keith Webber , Barnett S. Pitzele , Alok K. Awasthi , Alan Moormann
发明人： Richard C. Durley , James Sikorski , Donald W. Hansen, Jr. , Michelle A. Promo , Ronald Keith Webber , Barnett S. Pitzele , Alok K. Awasthi , Alan Moormann
IPC分类号： A61K31/195
CPC分类号： C07D209/48 , A61K31/198 , C07C229/30 , C07C251/08 , C07C251/16 , C07C255/30 , C07C257/14 , C07C271/22 , C07D271/07 , C07D413/06
摘要： The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
摘要翻译： 本发明涉及2-氨基-2-烷基-4-己烯酸和己酸衍生物及其在治疗中的用途，特别是其用作一氧化氮合酶抑制剂。
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2.发明授权2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives useful as nitric oxide synthase inhibitors 失效可用作一氧化氮合酶抑制剂的2-氨基-2-烷基-4-己烯酸和己炔酸衍生物公开(公告)号：US06756406B2
公开(公告)日：2004-06-29
申请号：US09952906
申请日：2001-09-15
申请人： Richard C. Durley , James Sikorski , Donald W. Hansen, Jr. , Michelle A. Promo , Ronald Keith Webber , Barnett S. Pitzele , Alok K. Awasthi , Alan Moorman
发明人： Richard C. Durley , James Sikorski , Donald W. Hansen, Jr. , Michelle A. Promo , Ronald Keith Webber , Barnett S. Pitzele , Alok K. Awasthi , Alan Moorman
IPC分类号： C07D27106
CPC分类号： C07D209/48 , A61K31/198 , C07C229/30 , C07C251/08 , C07C251/16 , C07C255/30 , C07C257/14 , C07C271/22 , C07D271/07 , C07D413/06
摘要： The present invention relates to 2-amino-2-alkyl-4 hexenoic and hexynoic acid derivatives and their use in therapy, in particular their use as nitric oxide synthase inhibitors.
摘要翻译： 本发明涉及2-氨基-2-烷基-4-己烯酸和己酸衍生物及其在治疗中的用途，特别是其用作一氧化氮合酶抑制剂。
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3.发明授权Halogenated 2-amino-3, 4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors 失效用作一氧化氮合酶抑制剂的卤化2-氨基-3,4-庚烯酸衍生物公开(公告)号：US06586471B1
公开(公告)日：2003-07-01
申请号：US09835193
申请日：2001-04-13
申请人： Donald W. Hansen, Jr. , Barnett S. Pitzele , Ronald Keith Webber , Mihaly V. Toth , Pamela T. Manning , Alok K. Awasthi , Mahima Trivedi
发明人： Donald W. Hansen, Jr. , Barnett S. Pitzele , Ronald Keith Webber , Mihaly V. Toth , Pamela T. Manning , Alok K. Awasthi , Mahima Trivedi
IPC分类号： A61K3122
CPC分类号： C07D209/48 , C07C257/14 , C07D263/04 , C07D263/06 , C07D413/06
摘要： The present invention contains halogenated 2-amino-3,4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
摘要翻译： 本发明包含可用作一氧化氮合酶抑制剂的卤代2-氨基-3,4-庚烯酸衍生物。
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4.发明授权Halogenated 2-amino-4, 5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors 失效用作一氧化氮合酶抑制剂的卤代2-氨基-4,5-庚烯酸衍生物公开(公告)号：US06465518B2
公开(公告)日：2002-10-15
申请号：US09834361
申请日：2001-04-13
IPC分类号： A01N3712
CPC分类号： C07C257/14
摘要： The present invention contains halogenated 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
摘要翻译： 本发明包含可用作一氧化氮合酶抑制剂的卤代2-氨基-4,5-庚烯酸衍生物。
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公开(公告)号：US06403830B2
公开(公告)日：2002-06-11
申请号：US09816577
申请日：2001-03-23
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey S. Snyder , Mahima Trivedi , Sofya Tsymbalov
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey S. Snyder , Mahima Trivedi , Sofya Tsymbalov
IPC分类号： C07C32358
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to S-[2-[(1-Iminoethyl)amino]ethyl]-2-methyl-L-cysteine, or a pharmaceutically acceptable salt thereof.
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公开(公告)号：US07196118B2
公开(公告)日：2007-03-27
申请号：US11032650
申请日：2005-01-10
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： A61K31/195
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
摘要翻译： 本发明涉及脒基化合物及其盐和前药。 在另一个实施方案中，本发明还提供本发明化合物在治疗中的用途，特别是作为一氧化氮合酶抑制剂。 在另一个实施方案中，本发明提供了制备脒基化合物的方法。
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公开(公告)号：US06586474B2
公开(公告)日：2003-07-01
申请号：US09816575
申请日：2001-03-23
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： A61K31195
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
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![Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors](/abs-image/US/2003/04/22/US06552052B2/abs.jpg.150x150.jpg)
8.发明授权Pyrrolo[2,1-c][1,2,4] thiadiazoles and Pyrollo[2,1-c][1,12,4]oxadiazoles useful as nitric oxide synthase inhibitors 失效吡咯并[2,1-c] [1,2,4]噻二唑和Pyrollo [2,1-c] [1,12,4]恶二唑可用作一氧化氮合酶抑制剂公开(公告)号：US06552052B2
公开(公告)日：2003-04-22
申请号：US09818297
申请日：2001-03-26
申请人： Donald W. Hansen, Jr. , R. Keith Webber , E. Ann Hallinan , Mihaly V. Toth , Barnett S. Pitzele , Alok K. Awasthi , Alan E. Moormann , Suzanne Metz , Jeffery S. Snyder , William M. Moore , Jeffrey A. Scholten
发明人： Donald W. Hansen, Jr. , R. Keith Webber , E. Ann Hallinan , Mihaly V. Toth , Barnett S. Pitzele , Alok K. Awasthi , Alan E. Moormann , Suzanne Metz , Jeffery S. Snyder , William M. Moore , Jeffrey A. Scholten
IPC分类号： C07D27112
CPC分类号： C07D487/04 , C07D513/04 , C07D515/04 , C07F9/6561
摘要： Pyrrolo[2,1-c][1,2,4]thiadiazole or pyrollo[2,1-c][1,2,4]oxadiazoles having the formula: or pharmaceutically acceptable salts thereof, useful as nitric oxide synthase inhibitors wherein each substituent is defined herein.
摘要翻译： 具有下式的吡咯并[2,1-c] [1,2,4]噻二唑或pyrollo [2,1-c] [1,2,4]恶二唑或其药学上可接受的盐，其可用作一氧化氮合酶抑制剂，其中 每个取代基在本文中定义。
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公开(公告)号：US06495544B2
公开(公告)日：2002-12-17
申请号：US09920612
申请日：2001-08-01
申请人： Donald W. Hansen, Jr. , Jeffrey S. Snyder , Alan E. Moormann , Alok K. Awasthi , Ronald Keith Webber , Thaddeus S. Franczyk , Mahima Trivedi
发明人： Donald W. Hansen, Jr. , Jeffrey S. Snyder , Alan E. Moormann , Alok K. Awasthi , Ronald Keith Webber , Thaddeus S. Franczyk , Mahima Trivedi
IPC分类号： A61K3155
CPC分类号： C07D223/12 , C07D223/10
摘要： Homoiminopiperidinyl Hexanoic Acid derivatives and pharmaceutically acceptable salts thereof useful in the inhibition of the inducible isoform of nitric oxide synthase are disclosed.
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10.发明授权Halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors 失效用作一氧化氮合酶抑制剂的卤代2-氨基-5,6-庚烯酸衍生物公开(公告)号：US06465686B2
公开(公告)日：2002-10-15
申请号：US09835191
申请日：2001-04-13
申请人： Margaret L. Grapperhaus , James A. Sikorski , Alok K. Awasthi , Lijuan J. Wang , Barnett S. Pitzele , Donald W. Hansen, Jr. , Pamela T. Manning
发明人： Margaret L. Grapperhaus , James A. Sikorski , Alok K. Awasthi , Lijuan J. Wang , Barnett S. Pitzele , Donald W. Hansen, Jr. , Pamela T. Manning
IPC分类号： C07C24100
CPC分类号： C07D271/07 , C07B2200/07 , C07C257/14 , C07C259/14 , C07D257/06
摘要： The present invention discloses halogenated 2-amino-5,6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
摘要翻译： 本发明公开了用作一氧化氮合酶抑制剂的卤代2-氨基-5,6-庚烯酸衍生物。
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