公开(公告)号：US08983609B2

公开(公告)日：2015-03-17

申请号：US12129734

申请日：2008-05-30

申请人： Ali R. Rezai ,  Milind Deogaonkar

发明人： Ali R. Rezai ,  Milind Deogaonkar

IPC分类号： A61N1/36 ,  A61N1/05

CPC分类号： A61N1/0553 ,  A61N1/0519 ,  A61N1/0556 ,  A61N1/3611 ,  A61N1/36114

摘要： An apparatus for positioning at a target site and for treating a pulmonary condition in a subject includes a fluid exchange catheter for insertion into a tracheo-bronchial tree and an inflatable balloon coupled to the fluid exchange catheter. At least a portion of the inflatable balloon is for engaging a luminal wall of the tracheo-bronchial tree at the target site. The apparatus further includes an energy delivery mechanism operably coupled to the inflatable balloon. The energy delivery mechanism includes at least one energy delivery member for delivering electrical energy to the target site.

摘要翻译： 用于定位在目标部位并用于治疗受试者的肺部病症的装置包括用于插入气管支气管树的树脂和用于与流体交换导管联接的可充气气囊的流体交换导管。 可充气气囊的至少一部分用于在目标位置处接合气管支气管树的腔壁。 该装置还包括可操作地联接到可膨胀气囊的能量传递机构。 能量输送机构包括用于将电能传递到目标部位的至少一个能量传递部件。

公开(公告)号：US20130238068A1

公开(公告)日：2013-09-12

申请号：US13857815

申请日：2013-04-05

申请人： Andre MACHADO ,  Ali R. REZAI

发明人： Andre MACHADO ,  Ali R. REZAI

IPC分类号： A61N1/05

CPC分类号： A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/3605 ,  A61N1/36082

摘要： Neuromodulation assemblies with lead bodies having curvatures that mimic the curvatures of the splenium, trunk, genu, or rostrum of the corpus callosum. Methods of stimulating the corpus callosum and methods of securing an electrical lead in the brain are also provided.

摘要翻译： 具有引导体的神经调节组件具有模拟胼the体的脾，躯干，g或者讲台的曲率的曲率。 还提供了刺激胼the体的方法和将电铅固定在脑中的方法。

公开(公告)号：US07833174B2

公开(公告)日：2010-11-16

申请号：US10502611

申请日：2003-01-31

申请人： Ali R. Rezai ,  Ashwini D. Sharan

发明人： Ali R. Rezai ,  Ashwini D. Sharan

IPC分类号： A61B5/00

CPC分类号： A61B34/73 ,  A61B34/70

摘要： A method and apparatus (10) for advancing a device (12) underneath the skin (102) in a mammalian body comprises a casing (50) made of a magnetic material. The casing (50) has a closed tip (64) at one end and an aperture (65) in an opposite end. The casing (50) includes an annular inner surface (70) that defines a cavity (76) within the casing for receiving a device (12) that projects through the aperture (65). The casing (50) further includes structure for attaching to the device (12). The casing (50) is operable to advance the device (12) through tissue (100) underlying the skin (102) in response to movement of a magnetic field across the skin.

摘要翻译： 用于使哺乳动物体内的皮肤（102）下方的装置（12）前进的方法和装置（10）包括由磁性材料制成的壳体（50）。 壳体（50）在一端具有封闭的尖端（64）和相对端的孔（65）。 壳体（50）包括在壳体内限定空腔（76）的环形内表面（70），用于接收突出穿过孔（65）的装置（12）。 壳体（50）还包括用于附接到装置（12）的结构。 壳体（50）可操作以响应于穿过皮肤的磁场的移动而将装置（12）推进穿过皮肤（102）下方的组织（100）。

公开(公告)号：US20100185269A1

公开(公告)日：2010-07-22

申请号：US12717632

申请日：2010-03-04

申请人： Andre Machado ,  Ali R. Rezai

发明人： Andre Machado ,  Ali R. Rezai

IPC分类号： A61N1/05 ,  A61B17/00

CPC分类号： A61N1/0531 ,  A61N1/0534 ,  A61N1/0539 ,  A61N1/3605 ,  A61N1/36082

摘要： Neuromodulation assemblies with lead bodies having curvatures that mimic the curvatures of the splenium, trunk, genu, or rostrum of the corpus callosum. Methods of stimulating the corpus callosum and methods of securing an electrical lead in the brain are also provided.

摘要翻译： 具有引导体的神经调节组件具有模拟胼the体的脾，躯干，g或者讲台的曲率的曲率。 还提供了刺激胼the体的方法和将电铅固定在脑中的方法。

公开(公告)号：US07697991B2

公开(公告)日：2010-04-13

申请号：US11121056

申请日：2005-05-04

申请人： Andre Machado ,  Ali R. Rezai

发明人： Andre Machado ,  Ali R. Rezai

IPC分类号： A61N1/18

CPC分类号： A61N1/36103 ,  A61N1/36067 ,  A61N1/36075 ,  A61N1/36082

摘要： Methods of treating various medical conditions by neuromodulation of a target site of interhemispheric fibers. Such medical conditions include unilateral motor deficits, movement disorders, psychiatric disorders, speech or cognitive deficits associated with hemispheric lesions, visual deficits associated with hemispheric lesions, hereditary/genetic disorders, congenital malformations, infection disease, degenerative disorder, autoimmune disorders, and metabolic disorders. A method of providing recovery and rehabilitation from states of reduced consciousness by neuromodulating a target site of interhemispheric fibers is also provided.

摘要翻译： 通过神经调节大脑半球纤维目标部位治疗各种疾病的方法。 这种医疗状况包括单侧运动障碍，运动障碍，精神障碍，与半球病变相关的言语或认知缺陷，与半球病变相关的视力缺陷，遗传性/遗传性疾病，先天性畸形，感染疾病，退行性疾病，自身免疫性疾病和代谢性疾病 。 还提供了一种通过神经调节大脑半球纤维的目标部位来提供恢复和恢复的意识降低的方法。

公开(公告)号：US20080208305A1

公开(公告)日：2008-08-28

申请号：US12016115

申请日：2008-01-17

申请人： Ali R. Rezai ,  Medhi Ansarinia ,  Milind Deogaonkar

发明人： Ali R. Rezai ,  Medhi Ansarinia ,  Milind Deogaonkar

IPC分类号： A61N1/05

CPC分类号： A61N1/0553 ,  A61N1/0556 ,  A61N1/36114

摘要： A method for treating a pulmonary condition in a subject includes one step of providing an implantable electrode assembly. The implantable electrode assembly includes a flexible member, at least one electrode operably secured to the flexible member, and an attachment mechanism for securing the at least one electrode to the flexible member. The implantable electrode assembly is implanted at a target site including an intraluminal location innervated by at least one nerve of the autonomic nervous system (ANS). The implantable electrode assembly is positioned at the target site such that the flexible member conforms to a portion of the inner surface of the target site, and the at least one electrode is positioned substantially adjacent the at least one nerve. Next, electric current is delivered to the at least one electrode to effect a change in the ANS of the subject.

摘要翻译： 用于治疗受试者的肺部疾病的方法包括提供可植入电极组件的一个步骤。 可植入电极组件包括柔性构件，可操作地固定到柔性构件的至少一个电极和用于将至少一个电极固定到柔性构件的附接机构。 可植入电极组件被植入靶区域，包括由自主神经系统的至少一个神经所支配的管腔内位置（ANS）。 可植入电极组件位于目标位置，使得柔性构件符合目标部位的内表面的一部分，并且至少一个电极基本上邻近至少一个神经定位。 接下来，将电流传送到至少一个电极以实现对象的ANS的改变。

公开(公告)号：US20080183248A1

公开(公告)日：2008-07-31

申请号：US12016127

申请日：2008-01-17

申请人： Ali R. Rezai ,  Medhi Ansarina ,  Milind Deogaonkar

发明人： Ali R. Rezai ,  Medhi Ansarina ,  Milind Deogaonkar

IPC分类号： A61N1/375 ,  A61N1/05 ,  A61N1/36

CPC分类号： A61N1/0553 ,  A61N1/0556 ,  A61N1/36114

摘要： An endotracheal apparatus includes a stent member including first and second ends and a lumen extending between the ends. The lumen defines an inner surface opposite an outer surface. The apparatus also includes an electrode assembly operably coupled to the stent member. The electrode assembly includes a flexible member having first and second end portions and oppositely disposed first and second surfaces, at least one electrode is operably connected to a portion of at least one of the first or second surfaces, and an attachment mechanism for securing the at least one electrode to at least one of the first or second surfaces. The at least one electrode is adapted to selectively deliver electric current to the target site and effect a change in the autonomic nervous system of the subject.

摘要翻译： 气管内装置包括支架构件，其包括第一端和第二端以及在端部之间延伸的内腔。 内腔限定与外表面相对的内表面。 该装置还包括可操作地联接到支架构件的电极组件。 电极组件包括具有第一和第二端部和相对设置的第一和第二表面的柔性构件，至少一个电极可操作地连接到第一或第二表面中的至少一个的一部分，以及用于固定在 至少一个电极到所述第一或第二表面中的至少一个。 所述至少一个电极适于选择性地将电流输送到目标部位并且影响受试者的自主神经系统的变化。

公开(公告)号：US07181288B1

公开(公告)日：2007-02-20

申请号：US10603243

申请日：2003-06-24

申请人： Ali R. Rezai ,  John D. Hall ,  Barry D. Kuban ,  Ken Baker

发明人： Ali R. Rezai ,  John D. Hall ,  Barry D. Kuban ,  Ken Baker

IPC分类号： A61N1/04

CPC分类号： A61N1/0529 ,  A61N1/0534

摘要： A device for modulating a volume of neural tissue comprising: a cannula having a proximal end, a distal end, and a lumen extending to at least the distal end, an actuator mechanism at least partially disposed in the lumen of the cannula; a plurality of leads having at least one electrode disposed thereon, the plurality of leads being coupled to the actuator mechanism to reciprocate between a retracted position wherein the plurality of leads are radially constrained within the lumen and an extended position; and a guide provided at the distal end of the cannula to deflect the plurality of leads radially outwardly into the neural tissue when the actuator mechanism is moved to the extended position.

摘要翻译： 一种用于调节神经组织的体积的装置，包括：套管，其具有近端，远端和至少延伸到所述远端的内腔，致动器机构至少部分地设置在所述套管的内腔中; 多个引线，其上设置有至少一个电极，所述多个引线联接到所述致动器机构以在缩回位置之间往复运动，在所述缩回位置，所述多个引线径向地限制在所述内腔内和延伸位置; 以及引导件，其设置在套管的远端处，以在致动器机构移动到伸出位置时将多个引线径向向外偏转进入神经组织。

公开(公告)号：US06708064B2

公开(公告)日：2004-03-16

申请号：US10036340

申请日：2001-12-24

申请人： Ali R. Rezai

发明人： Ali R. Rezai

IPC分类号： A61N118

CPC分类号： A61N1/36082

摘要： A method for treating neurological conditions by proper placement of a probe and sensing, stimulating or both areas of the brain especially the intralaminar nuclei (ILN”). Moreover, stimulation is controlled and offered when certain conditions within the area of interest are detected. Stimulation and sensing include electrical, chemical or combinations thereof.

公开(公告)号：US06356787B1

公开(公告)日：2002-03-12

申请号：US09511841

申请日：2000-02-24

申请人： Ali R. Rezai ,  Martin Zonenshayn

发明人： Ali R. Rezai ,  Martin Zonenshayn

IPC分类号： A61N132

CPC分类号： A61N1/32 ,  A61N1/05

摘要： A method for treating excessive facial blushing by applying an oscillating electric field to the stellate ganglion. The method includes the steps of inserting an electrode into the vacinity of the sympathetic ganglion, for example the stellate ganglion, such that the necessary electric field may be applied to the ganglion. The necessary field oscillation frequency and strength, as well as other characteristics of the signal are determined individually for each patient. Continued driving of the pathological activity of the ganglion into the normal function is the long-term, reversible palatative remedy for the condition.

摘要翻译： 一种通过向星状神经节施加振荡电场来治疗过度面部脸部红肿的方法。 该方法包括以下步骤：将电极插入交感神经节的空位，例如星状神经节，使得必要的电场可以应用于神经节。 对于每个患者单独确定必要的场振荡频率和强度以及信号的其它特征。 继续驱动神经节的病理活动进入正常功能，是对病情的长期，可逆的适口补救。