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1.发明授权公开(公告)号：US09616100B2
公开(公告)日：2017-04-11
申请号：US14333483
申请日：2014-07-16
Applicant: Sergei B Onikienko , Alex Nivorozhkin , Alexander V Zemlyanoi
Inventor： Sergei B Onikienko , Alex Nivorozhkin , Alexander V Zemlyanoi
CPC classification number: A61K38/17 , A61K38/1703 , A61K47/60
Abstract: The present invention relates to novel therapies that utilize exogenous HSP70 for the treatment of disorders or conditions regulated by HSP70 through administration of exogenous HSP70.
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公开(公告)号：US10052376B2
公开(公告)日：2018-08-21
申请号：US14255931
申请日：2014-04-17
Applicant: Sergey B. Onikienko , Alexander V. Zemlyanoi , Boris A. Margulis , Irina V. Guzhova , Anna A. Pimenova
Inventor： Sergey B. Onikienko , Alexander V. Zemlyanoi , Boris A. Margulis , Irina V. Guzhova , Anna A. Pimenova
IPC: A61K39/12 , A61N5/06 , A61N5/067 , C12N15/90 , A61K39/29 , A61K39/095 , A61K39/145 , A61K39/39 , C12N7/00 , A61K39/00
CPC classification number: A61K39/29 , A61K39/095 , A61K39/12 , A61K39/145 , A61K39/292 , A61K39/39 , A61K2039/53 , A61K2039/545 , A61K2039/55516 , A61N5/0613 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , C12N7/00 , C12N2730/10134 , C12N2750/00034 , C12N2760/16034 , C12N2760/16134
Abstract: The invention is directed to a vaccine for generating an enhanced immune response in a subject previously exposed to non-destructive laser radiation, as compared to an immune response in a subject previously non-exposed to non-destructive laser radiation. The invention is also directed to use of a composition comprising a vaccine for use in combination with non-destructive laser radiation for generating an enhanced immune response from a subject, as compared to an immune response without the use of laser radiation. The laser exposure acts as an adjuvant for the vaccine, increasing the efficacy and/or potency of the vaccine.
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公开(公告)号：US09217018B2
公开(公告)日：2015-12-22
申请号：US13716087
申请日：2012-12-15
Applicant: Sergei B Onikienko , Alex Nivorozhkin , Alexander V Zemlyanoi , Mikhail Viktorovich Shorokhov , Vladimir Ivanovich Pereguda , Valery Aleksandrovich Chereshnev
Inventor： Sergei B Onikienko , Alex Nivorozhkin , Alexander V Zemlyanoi , Mikhail Viktorovich Shorokhov , Vladimir Ivanovich Pereguda , Valery Aleksandrovich Chereshnev
CPC classification number: C07K14/47 , A61K38/1709 , C07K14/435 , C07K16/46 , C07K2319/00 , C07K2319/30 , C07K2319/50
Abstract: The present invention relates to novel therapies that utilize HSP70 fusion proteins for the treatment of disorders or conditions regulated by HSP70.
Abstract translation: 本发明涉及利用HSP70融合蛋白治疗由HSP70调节的病症或病症的新疗法。
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4.发明申请NOVEL METHODS OF USE OF HSP70 FOR INCREASED PERFORMANCE OR TREATMENT OF HSP70 RELATED DISORDERS 审中-公开HSP70用于增加HSP70相关疾病的性能或治疗的新方法公开(公告)号：US20140329764A1
公开(公告)日：2014-11-06
申请号：US14333483
申请日：2014-07-16
Applicant: Sergei B. Onikienko , Alex Nivorozhkin , Alexander V. Zemlyanoi
Inventor： Sergei B. Onikienko , Alex Nivorozhkin , Alexander V. Zemlyanoi
CPC classification number: A61K38/17 , A61K38/1703 , A61K47/60
Abstract: The present invention relates to novel therapies that utilize exogenous HSP70 for the treatment of disorders or conditions regulated by HSP70 through administration of exogenous HSP70.
Abstract translation: 本发明涉及利用外源性HSP70治疗通过施用外源HSP70而由HSP70调节的病症或病症的新疗法。
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Patent Agency Ranking
公开(公告)号：US20140335110A1
公开(公告)日：2014-11-13
申请号：US14255931
申请日：2014-04-17
Applicant: Sergey B. ONIKIENKO , Alexander V. ZEMLYANOI , Boris A. MARGULIS , Irina V. GUZHOVA , Anna A. PIMENOVA
Inventor： Sergey B. ONIKIENKO , Alexander V. ZEMLYANOI , Boris A. MARGULIS , Irina V. GUZHOVA , Anna A. PIMENOVA
IPC: A61K39/29 , C12N7/00 , A61K39/145
CPC classification number: A61K39/29 , A61K39/095 , A61K39/12 , A61K39/145 , A61K39/292 , A61K39/39 , A61K2039/53 , A61K2039/545 , A61K2039/55516 , A61N5/0613 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , C12N7/00 , C12N2730/10134 , C12N2750/00034 , C12N2760/16034 , C12N2760/16134
Abstract: The invention is directed to a vaccine for generating an enhanced immune response in a subject previously exposed to non-destructive laser radiation, as compared to an immune response in a subject previously non-exposed to non-destructive laser radiation. The invention is also directed to use of a composition comprising a vaccine for use in combination with non-destructive laser radiation for generating an enhanced immune response from a subject, as compared to an immune response without the use of laser radiation. The laser exposure acts as an adjuvant for the vaccine, increasing the efficacy and/or potency of the vaccine.
Abstract translation: 与先前未暴露于非破坏性激光辐射的受试者的免疫应答相比，本发明涉及用于在先前暴露于非破坏性激光辐射的受试者中产生增强的免疫应答的疫苗。 本发明还涉及与不使用激光辐射的免疫应答相比，包含疫苗的组合物与非破坏性激光辐射组合使用以产生来自受试者的增强的免疫应答的用途。 激光曝光作为疫苗的佐剂，增加疫苗的功效和/或效力。
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公开(公告)号：US20110059116A1
公开(公告)日：2011-03-10
申请号：US12754081
申请日：2010-04-05
Applicant: Sergey B. ONIKIENKO , Alexander V. ZEMLYANOI , Boris A. MARGULIS , Irina V. GUZHOVA , Anna A. PIMENOVA
Inventor： Sergey B. ONIKIENKO , Alexander V. ZEMLYANOI , Boris A. MARGULIS , Irina V. GUZHOVA , Anna A. PIMENOVA
CPC classification number: A61K39/29 , A61K39/095 , A61K39/12 , A61K39/145 , A61K39/292 , A61K39/39 , A61K2039/53 , A61K2039/545 , A61K2039/55516 , A61N5/0613 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , C12N7/00 , C12N2730/10134 , C12N2750/00034 , C12N2760/16034 , C12N2760/16134
Abstract: The invention is directed to a vaccine for generating an enhanced immune response in a subject previously exposed to non-destructive laser radiation, as compared to an immune response in a subject previously non-exposed to non-destructive laser radiation. The invention is also directed to use of a composition comprising a vaccine for use in combination with non-destructive laser radiation for generating an enhanced immune response from a subject, as compared to an immune response without the use of laser radiation. The laser exposure acts as an adjuvant for the vaccine, increasing the efficacy and/or potency of the vaccine.
Abstract translation: 与先前未暴露于非破坏性激光辐射的受试者的免疫应答相比，本发明涉及用于在先前暴露于非破坏性激光辐射的受试者中产生增强的免疫应答的疫苗。 本发明还涉及与不使用激光辐射的免疫应答相比，包含疫苗的组合物与非破坏性激光辐射组合使用以产生来自受试者的增强的免疫应答的用途。 激光曝光作为疫苗的佐剂，增加疫苗的功效和/或效力。
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公开(公告)号：US20130156694A1
公开(公告)日：2013-06-20
申请号：US13716087
申请日：2012-12-15
Applicant: Sergei B. Onikienko , Alex Nivorozhkin , Alexander V. Zemlyanoi , Mikhail Viktorovich Shorokhov , Vladimir Ivanovich Pereguda , Valery Aleksandrovich Chereshnev
Inventor： Sergei B. Onikienko , Alex Nivorozhkin , Alexander V. Zemlyanoi , Mikhail Viktorovich Shorokhov , Vladimir Ivanovich Pereguda , Valery Aleksandrovich Chereshnev
IPC: C07K14/435 , C07K16/46
CPC classification number: C07K14/47 , A61K38/1709 , C07K14/435 , C07K16/46 , C07K2319/00 , C07K2319/30 , C07K2319/50
Abstract: The present invention relates to novel therapies that utilize HSP70 fusion proteins for the treatment of disorders or conditions regulated by HSP70.
Abstract translation: 本发明涉及利用HSP70融合蛋白治疗由HSP70调节的病症或病症的新疗法。
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8.发明申请NOVEL METHODS OF USE OF HSP70 FOR INCREASED PERFORMANCE OR TREATMENT OF HSP70 RELATED DISORDERS 审中-公开HSP70用于增加HSP70相关疾病的性能或治疗的新方法公开(公告)号：US20130090294A1
公开(公告)日：2013-04-11
申请号：US13536542
申请日：2012-06-28
Applicant: Sergei B. Onikienko , Alex Nivorozhkin , Alexander V. Zemlyanoi
Inventor： Sergei B. Onikienko , Alex Nivorozhkin , Alexander V. Zemlyanoi
IPC: A61K38/17
CPC classification number: A61K38/17 , A61K38/1703 , A61K47/60
Abstract: The present invention relates to novel therapies that utilize exogenous HSP70 for the treatment of disorders or conditions regulated by HSP70 through administration of exogenous HSP70.
Abstract translation: 本发明涉及利用外源性HSP70治疗通过施用外源HSP70而由HSP70调节的病症或病症的新疗法。
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公开(公告)号：US20130078265A1
公开(公告)日：2013-03-28
申请号：US13428275
申请日：2012-03-23
Applicant: Sergey B. ONIKIENKO , Alexander V. ZEMLYANOI , Boris A. MARGULIS , Irina V. GUZHOVA , Anna A. PIMENOVA
Inventor： Sergey B. ONIKIENKO , Alexander V. ZEMLYANOI , Boris A. MARGULIS , Irina V. GUZHOVA , Anna A. PIMENOVA
IPC: A61K39/39
CPC classification number: A61K39/29 , A61K39/095 , A61K39/12 , A61K39/145 , A61K39/292 , A61K39/39 , A61K2039/53 , A61K2039/545 , A61K2039/55516 , A61N5/0613 , A61N2005/0659 , A61N2005/0662 , A61N2005/067 , C12N7/00 , C12N2730/10134 , C12N2750/00034 , C12N2760/16034 , C12N2760/16134
Abstract: The invention is directed to a vaccine for generating an enhanced immune response in a subject previously exposed to non-destructive laser radiation, as compared to an immune response in a subject previously non-exposed to non-destructive laser radiation. The invention is also directed to use of a composition comprising a vaccine for use in combination with non-destructive laser radiation for generating an enhanced immune response from a subject, as compared to an immune response without the use of laser radiation. The laser exposure acts as an adjuvant for the vaccine, increasing the efficacy and/or potency of the vaccine.
Abstract translation: 与先前未暴露于非破坏性激光辐射的受试者的免疫应答相比，本发明涉及用于在先前暴露于非破坏性激光辐射的受试者中产生增强的免疫应答的疫苗。 本发明还涉及与不使用激光辐射的免疫应答相比，包含疫苗的组合物与非破坏性激光辐射组合使用以产生来自受试者的增强的免疫应答的用途。 激光曝光作为疫苗的佐剂，增加疫苗的功效和/或效力。
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