公开(公告)号：US10052376B2

公开(公告)日：2018-08-21

申请号：US14255931

申请日：2014-04-17

Applicant: Sergey B. Onikienko ,  Alexander V. Zemlyanoi ,  Boris A. Margulis ,  Irina V. Guzhova ,  Anna A. Pimenova

Inventor： Sergey B. Onikienko ,  Alexander V. Zemlyanoi ,  Boris A. Margulis ,  Irina V. Guzhova ,  Anna A. Pimenova

IPC: A61K39/12 ,  A61N5/06 ,  A61N5/067 ,  C12N15/90 ,  A61K39/29 ,  A61K39/095 ,  A61K39/145 ,  A61K39/39 ,  C12N7/00 ,  A61K39/00

CPC classification number: A61K39/29 ,  A61K39/095 ,  A61K39/12 ,  A61K39/145 ,  A61K39/292 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55516 ,  A61N5/0613 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  C12N7/00 ,  C12N2730/10134 ,  C12N2750/00034 ,  C12N2760/16034 ,  C12N2760/16134

Abstract: The invention is directed to a vaccine for generating an enhanced immune response in a subject previously exposed to non-destructive laser radiation, as compared to an immune response in a subject previously non-exposed to non-destructive laser radiation. The invention is also directed to use of a composition comprising a vaccine for use in combination with non-destructive laser radiation for generating an enhanced immune response from a subject, as compared to an immune response without the use of laser radiation. The laser exposure acts as an adjuvant for the vaccine, increasing the efficacy and/or potency of the vaccine.

公开(公告)号：US20140335110A1

公开(公告)日：2014-11-13

申请号：US14255931

申请日：2014-04-17

Applicant: Sergey B. ONIKIENKO ,  Alexander V. ZEMLYANOI ,  Boris A. MARGULIS ,  Irina V. GUZHOVA ,  Anna A. PIMENOVA

Inventor： Sergey B. ONIKIENKO ,  Alexander V. ZEMLYANOI ,  Boris A. MARGULIS ,  Irina V. GUZHOVA ,  Anna A. PIMENOVA

IPC: A61K39/29 ,  C12N7/00 ,  A61K39/145

CPC classification number: A61K39/29 ,  A61K39/095 ,  A61K39/12 ,  A61K39/145 ,  A61K39/292 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55516 ,  A61N5/0613 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  C12N7/00 ,  C12N2730/10134 ,  C12N2750/00034 ,  C12N2760/16034 ,  C12N2760/16134

Abstract: The invention is directed to a vaccine for generating an enhanced immune response in a subject previously exposed to non-destructive laser radiation, as compared to an immune response in a subject previously non-exposed to non-destructive laser radiation. The invention is also directed to use of a composition comprising a vaccine for use in combination with non-destructive laser radiation for generating an enhanced immune response from a subject, as compared to an immune response without the use of laser radiation. The laser exposure acts as an adjuvant for the vaccine, increasing the efficacy and/or potency of the vaccine.

Abstract translation: 与先前未暴露于非破坏性激光辐射的受试者的免疫应答相比，本发明涉及用于在先前暴露于非破坏性激光辐射的受试者中产生增强的免疫应答的疫苗。 本发明还涉及与不使用激光辐射的免疫应答相比，包含疫苗的组合物与非破坏性激光辐射组合使用以产生来自受试者的增强的免疫应答的用途。 激光曝光作为疫苗的佐剂，增加疫苗的功效和/或效力。

公开(公告)号：US20110059116A1

公开(公告)日：2011-03-10

申请号：US12754081

申请日：2010-04-05

Applicant: Sergey B. ONIKIENKO ,  Alexander V. ZEMLYANOI ,  Boris A. MARGULIS ,  Irina V. GUZHOVA ,  Anna A. PIMENOVA

Inventor： Sergey B. ONIKIENKO ,  Alexander V. ZEMLYANOI ,  Boris A. MARGULIS ,  Irina V. GUZHOVA ,  Anna A. PIMENOVA

IPC: A61K39/00 ,  A61P31/00

CPC classification number: A61K39/29 ,  A61K39/095 ,  A61K39/12 ,  A61K39/145 ,  A61K39/292 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55516 ,  A61N5/0613 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  C12N7/00 ,  C12N2730/10134 ,  C12N2750/00034 ,  C12N2760/16034 ,  C12N2760/16134

Abstract: The invention is directed to a vaccine for generating an enhanced immune response in a subject previously exposed to non-destructive laser radiation, as compared to an immune response in a subject previously non-exposed to non-destructive laser radiation. The invention is also directed to use of a composition comprising a vaccine for use in combination with non-destructive laser radiation for generating an enhanced immune response from a subject, as compared to an immune response without the use of laser radiation. The laser exposure acts as an adjuvant for the vaccine, increasing the efficacy and/or potency of the vaccine.

Abstract translation: 与先前未暴露于非破坏性激光辐射的受试者的免疫应答相比，本发明涉及用于在先前暴露于非破坏性激光辐射的受试者中产生增强的免疫应答的疫苗。 本发明还涉及与不使用激光辐射的免疫应答相比，包含疫苗的组合物与非破坏性激光辐射组合使用以产生来自受试者的增强的免疫应答的用途。 激光曝光作为疫苗的佐剂，增加疫苗的功效和/或效力。

公开(公告)号：US20130078265A1

公开(公告)日：2013-03-28

申请号：US13428275

申请日：2012-03-23

Applicant: Sergey B. ONIKIENKO ,  Alexander V. ZEMLYANOI ,  Boris A. MARGULIS ,  Irina V. GUZHOVA ,  Anna A. PIMENOVA

Inventor： Sergey B. ONIKIENKO ,  Alexander V. ZEMLYANOI ,  Boris A. MARGULIS ,  Irina V. GUZHOVA ,  Anna A. PIMENOVA

IPC: A61K39/39

CPC classification number: A61K39/29 ,  A61K39/095 ,  A61K39/12 ,  A61K39/145 ,  A61K39/292 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55516 ,  A61N5/0613 ,  A61N2005/0659 ,  A61N2005/0662 ,  A61N2005/067 ,  C12N7/00 ,  C12N2730/10134 ,  C12N2750/00034 ,  C12N2760/16034 ,  C12N2760/16134

Abstract: The invention is directed to a vaccine for generating an enhanced immune response in a subject previously exposed to non-destructive laser radiation, as compared to an immune response in a subject previously non-exposed to non-destructive laser radiation. The invention is also directed to use of a composition comprising a vaccine for use in combination with non-destructive laser radiation for generating an enhanced immune response from a subject, as compared to an immune response without the use of laser radiation. The laser exposure acts as an adjuvant for the vaccine, increasing the efficacy and/or potency of the vaccine.

Abstract translation: 与先前未暴露于非破坏性激光辐射的受试者的免疫应答相比，本发明涉及用于在先前暴露于非破坏性激光辐射的受试者中产生增强的免疫应答的疫苗。 本发明还涉及与不使用激光辐射的免疫应答相比，包含疫苗的组合物与非破坏性激光辐射组合使用以产生来自受试者的增强的免疫应答的用途。 激光曝光作为疫苗的佐剂，增加疫苗的功效和/或效力。