公开(公告)号：US07001982B2

公开(公告)日：2006-02-21

申请号：US10403815

申请日：2003-03-31

申请人： Gangavaram Vasantha Madhava Sharma ,  Kondireddi Ravinder Reddy ,  Radha Krishna Palakodety ,  Ajit Chand Kunwar ,  Ravi Sankar Ampapathi ,  Jagannadh Bulusu ,  Jayaprakash Pagadala

发明人： Gangavaram Vasantha Madhava Sharma ,  Kondireddi Ravinder Reddy ,  Radha Krishna Palakodety ,  Ajit Chand Kunwar ,  Ravi Sankar Ampapathi ,  Jagannadh Bulusu ,  Jayaprakash Pagadala

IPC分类号： C07K1/06 ,  C07K2/00 ,  C07K5/023 ,  C07K7/02 ,  C07K9/00

CPC分类号： C07D493/04 ,  C07C237/22 ,  Y10S930/29

摘要： Nonnatural C-linked carbo-β-peptides with robust secondary structures, which involves the synthesis of a new class of β-peptides called C-linked carbo-β-peptides. The compounds are favorably disposed for the formation of stable helical structures and are useful as biologically active carbo-β-peptides. The new class of β-peptides have the following formula The new class of β-peptides are useful as biologically active molecules to disrupt biological interactions of proteins, for molecular design and to synthesize peptide libraries.

摘要翻译： 具有强烈二级结构的非天然C连接的碳-β-肽，其涉及合成称为C-连接的碳-β-肽的新类型的β-肽。 该化合物有利地用于形成稳定的螺旋结构，并且可用作生物活性的碳-β-肽。 新类型的β-肽具有以下化学式：化学式id =“CHEM-US-00001”num =“000”

公开(公告)号：US07060678B2

公开(公告)日：2006-06-13

申请号：US10638107

申请日：2003-08-08

申请人： Sudhanand Prasad ,  Tushar Kanti Chakraborty ,  Archna Mathur ,  Manu Jaggi ,  Ajit Chand Kunwar ,  Rama Mukherjee ,  Anand C. Burman

发明人： Sudhanand Prasad ,  Tushar Kanti Chakraborty ,  Archna Mathur ,  Manu Jaggi ,  Ajit Chand Kunwar ,  Rama Mukherjee ,  Anand C. Burman

IPC分类号： A61K38/07 ,  A61K38/08 ,  C07K5/02 ,  C07K7/02 ,  C07K9/00

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/1013 ,  C07K14/57563

摘要： Anticancer peptides which incorporate furanoid sugar amino acids and compositions made using these peptides are described. Methods for synthesis of the peptides and for preparing the furanoid sugar amino acids are disclosed. The peptides and compositions made using the peptides have pharmacological applications of these peptides especially in the treatment and prevention of cancer and tumors.

摘要翻译： 描述了掺入呋喃糖类氨基酸的抗癌肽和使用这些肽制备的组合物。 公开了合成肽和制备呋喃糖基氨基酸的方法。 使用肽制备的肽和组合物具有这些肽的药理学应用，特别是在治疗和预防癌症和肿瘤中。