公开(公告)号：US08663451B2

公开(公告)日：2014-03-04

申请号：US13161702

申请日：2011-06-16

申请人： Chih-Kung Lee ,  Adam Shih-Yuan Lee ,  Ching-Sung Chen ,  Ku-Ning Chang ,  Ying-Hua Chen ,  Bryan Yong-Jay Lee

发明人： Chih-Kung Lee ,  Adam Shih-Yuan Lee ,  Ching-Sung Chen ,  Ku-Ning Chang ,  Ying-Hua Chen ,  Bryan Yong-Jay Lee

IPC分类号： G01N27/327

CPC分类号： C07D333/34 ,  C07D333/18 ,  C07D333/22 ,  C07D333/38 ,  C07D409/04 ,  C07D409/14 ,  G01N33/54353 ,  G01N33/5438

摘要： The present invention provides a linker for joining an electrode and a capture probe on a biochip, and a biochip comprising the linker. The impedance baseline of the linker of the present invention is three orders lower than the conventional long chain thiol linker when adopting in a fadaraic impedance biochip construction. With lower impedance baseline, the device designed to measure the signal of the biochip of the present invention could be further simplied on the electrical circuit design and be made in lower cost, compacter size and get the potential to be used in point-of-care applications. The present invention also provides a method of quantitatively detecting a concentration of a target analyte in a fluid sample by adopting the biochip and the linker of present invention.

摘要翻译： 本发明提供了用于将生物芯片上的电极和捕获探针连接的接头和包含接头的生物芯片。 本发明的接头的阻抗基线在采用制动阻抗生物芯片结构时比传统的长链硫醇连接体低三个数量级。 利用较低的阻抗基线，设计用于测量本发明的生物芯片的信号的器件可以进一步简化电路设计，并且可以以更低的成本，更大的尺寸制造并获得在点护理中使用的潜力 应用程序。 本发明还提供一种通过采用本发明的生物芯片和接头来定量检测流体样品中的目标分析物的浓度的方法。

公开(公告)号：US20120067742A1

公开(公告)日：2012-03-22

申请号：US13161702

申请日：2011-06-16

申请人： Chih-Kung Lee ,  Adam Shih-Yuan Lee ,  Ching-Sung Chen ,  Ku-Ning Chang ,  Ying-Hua Chen ,  Bryan Yong-Jay Lee

发明人： Chih-Kung Lee ,  Adam Shih-Yuan Lee ,  Ching-Sung Chen ,  Ku-Ning Chang ,  Ying-Hua Chen ,  Bryan Yong-Jay Lee

IPC分类号： G01N27/327 ,  G01N33/50 ,  C07D409/04

CPC分类号： C07D333/34 ,  C07D333/18 ,  C07D333/22 ,  C07D333/38 ,  C07D409/04 ,  C07D409/14 ,  G01N33/54353 ,  G01N33/5438

摘要： The present invention provides a linker for joining an electrode and a capture probe on a biochip, and a biochip comprising the linker. The impedance baseline of the linker of the present invention is three orders lower than the conventional long chain thiol linker when adopting in a fadaraic impedance biochip construction. With lower impedance baseline, the device designed to measure the signal of the biochip of the present invention could be further simplied on the electrical circuit design and be made in lower cost, compacter size and get the potential to be used in point-of-care applications. The present invention also provides a method of quantitatively detecting a concentration of a target analyte in a fluid sample by adopting the biochip and the linker of present invention.

摘要翻译： 本发明提供了用于将生物芯片上的电极和捕获探针连接的接头和包含接头的生物芯片。 本发明的接头的阻抗基线在采用制动阻抗生物芯片结构时比传统的长链硫醇连接体低三个数量级。 利用较低的阻抗基线，设计用于测量本发明的生物芯片的信号的器件可以进一步简化电路设计，并且可以以更低的成本，更大的尺寸制造并获得在点护理中使用的潜力 应用程序。 本发明还提供一种通过采用本发明的生物芯片和接头来定量检测流体样品中的目标分析物的浓度的方法。

公开(公告)号：US5989900A

公开(公告)日：1999-11-23

申请号：US136722

申请日：1998-08-19

申请人： Adam Shih-Yuan Lee ,  Hsiu-Chih Yeh ,  Ohm-Guo Pan ,  Shyh-Fong Chen ,  Hao Ku

发明人： Adam Shih-Yuan Lee ,  Hsiu-Chih Yeh ,  Ohm-Guo Pan ,  Shyh-Fong Chen ,  Hao Ku

IPC分类号： C12P41/00 ,  C12P11/00 ,  C12P13/00

CPC分类号： C12P41/005

摘要： A process for preparing optically active allylic alcohol derivatives comprises reacting a racemic mixture of the following formula I ##STR1## wherein R is alkyl, alkenyl, or substituted or unsubstituted aryl or arylalkyl;with acetate or anhydride under the catalysis of Pseudomonase AK, PS or K-10 lipase in the presence of an organic solvent.

摘要翻译： 制备光学活性烯丙基醇衍生物的方法包括使下式I的外消旋混合物反应，其中R是烷基，烯基或取代或未取代的芳基或芳基烷基; 在有机溶剂存在下，用Pseudomonase AK，PS或K-10脂肪酶催化下用乙酸盐或酸酐处理。