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公开(公告)号：US20230293440A1
公开(公告)日：2023-09-21
申请号：US18180801
申请日：2023-03-08
CPC分类号： A61K9/19 , A61K39/00 , A61K39/04 , A61K39/39 , A61K47/22 , A61K47/26 , A61K47/10 , A61K2039/55572 , A61K2039/552 , A61K2039/55511
摘要： The invention provides for thermostable lyophilized formulations, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response, and methods of use thereof. The lyophilized formulations generally comprise an antigen and/or an adjuvant, a metabolizable oil, and a cake-forming excipient.
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公开(公告)号：US20230287038A1
公开(公告)日：2023-09-14
申请号：US18020253
申请日：2021-06-04
发明人： Yizhi QI , Christopher Bradford FOX
CPC分类号： C07J63/008 , A61K39/39 , G01N30/8631 , G01N30/72 , B01D15/305 , B01D15/325 , A61K2039/55577
摘要： Substantially pure saponin extracts and orthogonal chromatographic methods for purification of saponin extracts are disclosed. The purified saponin extracts may include QS-21 and can have a purity of greater than 97%. The orthogonal chromatographic method uses reversed-phase (RP) chromatography followed by hydrophilic interaction liquid chromatography (HILIC) to generate substantially pure saponin extracts.
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公开(公告)号：US20230116042A1
公开(公告)日：2023-04-13
申请号：US17960110
申请日：2022-10-04
发明人： Christopher FOX , Steven G. REED , Susan BALDWIN , Thomas VEDVICK
IPC分类号： A61K9/113 , A61K39/00 , A61K9/107 , A61K39/39 , A61K39/12 , A61K47/06 , A61K47/24 , A61K39/015 , A61K47/26
摘要： Formulations and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed. The formulations generally comprise a TLR4 agonist and a metabolizable oil at a concentration of about 0.01%-1% v/v, wherein the hydrophobic:lipophilic balance (HLB) of the emusion is greater than about 9.
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公开(公告)号：US20220257754A1
公开(公告)日：2022-08-18
申请号：US17731718
申请日：2022-04-28
发明人： Christopher B. FOX
IPC分类号： A61K39/39 , A61K39/04 , A61K39/12 , C07K14/705 , A61K35/76 , A61K45/06 , A61P31/12 , A61P33/04 , A61P31/06 , A61P35/00
摘要： Stable aqueous formulations of adjuvant comprising a TLR7/8 agonist or a TLR4 agonist with a helper lipid that are adsorbed to alum are provided. Compositions and methods of using the formulations for stimulating an immune response are also provided.
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公开(公告)号：US11376325B2
公开(公告)日：2022-07-05
申请号：US16899729
申请日：2020-06-12
发明人： Steven G. Reed , Darrick Carter
IPC分类号： A61K39/395 , A61K39/39 , A61K39/008 , A61K45/06 , A61K39/04 , A61K39/145 , A61K39/00 , C12N7/00
摘要： Compositions and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed based on the discovery of useful immunological adjuvant properties in a synthetic, glucopyranosyl lipid adjuvant (GLA) that is provided in substantially homogeneous form. Chemically defined, synthetic GLA offers a consistent vaccine component from lot to lot without the fluctuations in contaminants or activity that compromise natural-product adjuvants. Also provided are vaccines and pharmaceutical compositions that include GLA and one or more of an antigen, a Toll-like receptor (TLR) agonist, a co-adjuvant and a carrier such as a pharmaceutical carrier.
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公开(公告)号：US11801290B2
公开(公告)日：2023-10-31
申请号：US16333596
申请日：2017-09-15
发明人： Steven G. Reed , Malcolm S. Duthie
CPC分类号： A61K39/04 , A61K39/39 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/55577
摘要： Compositions and methods for preventing, treating and detecting leprosy are disclosed. The compositions generally comprise polypeptides comprising one or more Mycobacterium leprae antigens as well as polynucleotides encoding such polypeptides.
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7.发明公开公开(公告)号：US20230194447A1
公开(公告)日：2023-06-22
申请号：US18170114
申请日：2023-02-16
发明人： Yihua (Bruce) YU , Marc TARABAN , Christopher FOX
CPC分类号： G01N24/082 , G01N33/15
摘要： A method of using the transverse relaxation rate (R2) of solvent NMR signal to noninvasively assess alum-containing products such as vaccines. This technique can be used for quality control in vaccine manufacturing (e.g., fill-finish step) to determine the evenness of alum filling level as well as extent of alum particle sedimentation in filled and sealed products.
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公开(公告)号：US11585770B2
公开(公告)日：2023-02-21
申请号：US16593145
申请日：2019-10-04
发明人： Yihua (Bruce) Yu , Marc Taraban , Christopher Fox
摘要： A method of using the transverse relaxation rate (R2) of solvent NMR signal to noninvasively assess alum-containing products such as vaccines. This technique can be used for quality control in vaccine manufacturing (e.g., fill-finish step) to determine the evenness of alum filling level as well as extent of alum particle sedimentation in filled and sealed products.
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公开(公告)号：US11369672B2
公开(公告)日：2022-06-28
申请号：US16126285
申请日：2018-09-10
发明人： Steven G. Reed , Rhea N. Coler
IPC分类号： A61K39/04 , A61K31/4409 , A61K31/496 , A61K39/39 , A61K45/06 , A61K39/00
摘要： The present disclosure relates to methods and compositions for treating a active tuberculosis infection and methods and compositions for improving the efficacy of chemotherapy regimens against active tuberculosis infection. The present disclosure relates to methods of treating an active M. tuberculosis infection or an active infection resulting from reactivation of a latent infection in a mammal and to methods of improving the efficacy of chemotherapy regimens against active M. tuberculosis infection.
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10.发明授权公开(公告)号：US12061160B2
公开(公告)日：2024-08-13
申请号：US18170114
申请日：2023-02-16
发明人： Yihua (Bruce) Yu , Marc Taraban , Christopher Fox
CPC分类号： G01N24/082 , G01N33/15
摘要： A method of using the transverse relaxation rate (R2) of solvent NMR signal to noninvasively assess if an alum-containing product, such as a vaccine, has been acceptably resuspended for use following transport and/or storage. This technique allows for the manufacturer and/or distributor and/or end user to monitor for unexpected stressors associated with transport and/or storage including, but not limited to, temperature fluctuations, pH changes, vigorous shaking during transportation, exposure to sunlight, and freezing.
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