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公开(公告)号:US12118694B2
公开(公告)日:2024-10-15
申请号:US18319053
申请日:2023-05-17
CPC分类号: G06T5/50 , A61B6/4241 , A61B6/463 , A61B6/482 , A61B6/504 , A61B6/5247 , G06T7/0012 , G06T7/174 , G06T2207/10081 , G06T2207/10088 , G06T2207/10132 , G06T2207/20216 , G06T2207/20224
摘要: Systems and methods for improving soft tissue contrast, characterizing tissue, classifying phenotype, stratifying risk, and performing multi-scale modeling aided by multiple energy or contrast excitation and evaluation are provided. The systems and methods can include single and multi-phase acquisitions and broad and local spectrum imaging to assess atherosclerotic plaque tissues in the vessel wall and perivascular space.
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公开(公告)号:US12115146B2
公开(公告)日:2024-10-15
申请号:US17066487
申请日:2020-10-09
IPC分类号: A61K31/277 , A61K31/167 , A61K31/404 , A61K31/4704 , A61P35/00 , A61K9/00 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/107 , A61K9/16 , A61K9/48
CPC分类号: A61K31/277 , A61K31/167 , A61K31/404 , A61K31/4704 , A61P35/00 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/0053 , A61K9/02 , A61K9/06 , A61K9/08 , A61K9/10 , A61K9/107 , A61K9/1605 , A61K9/4866
摘要: This invention relates to the treatment of breast cancer in a subject, for example a female subject. Including methods of: treating metastatic breast cancer; refractory breast cancer; AR-positive breast cancer; AR-positive refractory breast cancer; AR-positive metastatic breast cancer; AR-positive and ER-positive breast cancer; triple negative breast cancer; advanced breast cancer; breast cancer that has failed selective estrogen receptor modulator (SERM) (tamoxifen, toremifene, raloxifene), gonadotropin-releasing hormone (GnRH) agonist (goserelin), aromatase inhibitor (AI) (letrozole, anastrozole, exemestane), cyclin-dependent kinase 4/6 (CDK 4/6) inhibitor (palbociclib (Ibrance), ribociclib (Kisqali), abemaciclib (Vorzenio)), mTOR inhibitor (everolimus), trastuzumab (Herceptin, ado-trastuzumab emtansine), pertuzumab (Perjeta), lapatinib, neratinib (Nerlynx), olaparib (Lynparza) (an inhibitor of the enzyme poly ADP ribose polymerase (PARP)), bevacizumab (Avastin), and/or fulvestrant treatments; metastasis in a subject suffering from breast cancer; HER2-positive; treating a subject suffering from ER mutant expressing breast cancer and/or treating breast cancer in a subject, by first determining the 18F-16β-fluoro-5α-dihydrotestosterone (18F-DHT) tumor uptake and identifying said subject as having AR-positive breast cancer based on 18F-DHT tumor uptake, comprising administering to the subject a therapeutically effective amount of a selective androgen receptor modulator (SARM) compound.
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公开(公告)号:US12106083B2
公开(公告)日:2024-10-01
申请号:US17671804
申请日:2022-02-15
申请人: InContact Inc.
发明人: Ankita Jhanwar , Darshan Ambhaikar , Nishu Bansal , Piyush Jain , Sarang Panajkar , Seemit Shah
摘要: A system and method for rule selection may include using one or more processors in a computer server, for a set of rules, each rule having one or more rule criteria, determining for each rule if the result of an interaction between interaction metadata and the one or more rule criteria includes one or more criteria. For each rule where the intersection includes one or more criteria, a complement result may be calculated between the result of the intersection and the rule criteria; and based on the complement result, wherein if the complement result is null, the rule may be selected.
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公开(公告)号:US12102867B1
公开(公告)日:2024-10-01
申请号:US17406360
申请日:2021-08-19
申请人: Ashford Fitness LLC
发明人: Jason Linde
IPC分类号: A63B21/00
CPC分类号: A63B21/154 , A63B21/4035
摘要: An exercise device uses a vertically oriented member with multiple sheaves. Each sheave may be disposed around three different heights of the vertical member. A first sheave may be disposed substantially at a first end of the member. A second sheave may be disposed substantially at second end of the member. A third sheave may be disposed substantially at the center of the member. A flexible line may be connected to a weight at one end of the line, and the flexible line is then threaded through at least two of the first sheave, second sheave or third sheave.
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公开(公告)号:US12102627B2
公开(公告)日:2024-10-01
申请号:US16952123
申请日:2020-11-19
发明人: Michal Geva , Ralph Laufer , Michael Hayden
IPC分类号: A61K31/451 , A61K9/00 , A61P25/14
CPC分类号: A61K31/451 , A61K9/0019 , A61K9/0053 , A61P25/14
摘要: The subject invention provides a method for treating a subject afflicted with Rett syndrome comprising administering to the subject an effective amount of pridopidine so as to thereby treat the subject.
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公开(公告)号:US12093648B2
公开(公告)日:2024-09-17
申请号:US17178754
申请日:2021-02-18
申请人: Nice Ltd.
发明人: Stephen Lauber
IPC分类号: G06F40/289 , G06F16/35 , G06F40/30
CPC分类号: G06F40/289 , G06F16/355 , G06F40/30
摘要: A system and method for determining an embedding for a document (e.g. representing the document in vector space) by determining for the document a preliminary document embedding; determining for the document a document topic embedding based on a set of nearest topics to the preliminary document embedding; determining for each phrase in the document a topic relevancy score based on the document topic embedding and the embedding associated with the phrase; using a ranking algorithm to determine a saliency score for each phrase in the document, each saliency score based on the topic relevancy score for the phrase, and an inverse frequency score for the phrase; and calculating an embedding for the document using the saliency scores and embedding, for the phrases in the document.
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公开(公告)号:US12092292B2
公开(公告)日:2024-09-17
申请号:US17968699
申请日:2022-10-18
申请人: MPOWERD Inc.
发明人: Seungah Jeong , John Salzinger , Scott Klimcke , Juan S. Jacobo
IPC分类号: F21S9/03 , F21V23/06 , F21Y115/00
CPC分类号: F21S9/037 , F21V23/06 , F21Y2115/00
摘要: Modular and portable solar-powered lighting devices are described. The device may include a handle assembly including a rechargeable battery and a solar panel electrically connected to the rechargeable battery, a mounting assembly selectively attachable to the handle assembly, and a lighting assembly selectively attachable to the handle assembly, the lighting assembly including one or more light sources. The device may have a first configuration wherein the handle assembly is coupled to each of the lighting assembly and the mounting assembly; and a second configuration wherein the lighting assembly is attached to the mounting assembly and not coupled to the handle assembly. These configurations can resemble a flashlight and a headlamp, respectively.
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公开(公告)号:US12089928B2
公开(公告)日:2024-09-17
申请号:US16612383
申请日:2018-05-17
申请人: WEAR2B LTD.
发明人: Mordechai Itzkovich , Ohad Bashan , Giora Bar-Sakai , Oded Bashan
IPC分类号: A61B5/1455 , A61B5/00 , A61B5/145
CPC分类号: A61B5/1455 , A61B5/002 , A61B5/14532 , A61B5/7221 , A61B5/7275
摘要: A non-invasive monitoring device for monitoring physiological condition of a subject may include at least one light source for emitting light at at least one predetermined narrow spectral wavelength band onto a living tissue of the subject and two or more light sensors. Each of the two or more light sensors may correspond to a specific substance in a living tissue of the subject and may be configured to measure a change in a concentration of the specific substances to which the sensor corresponds. The distance of each of the two or more sensors from the light source, may be determined so that intensity of light scattered by each specific substance, may have a maximal signal to noise ratio at the determined distance of the corresponding sensor.
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公开(公告)号:US12083575B2
公开(公告)日:2024-09-10
申请号:US17142003
申请日:2021-01-05
IPC分类号: B21D51/16 , B21D26/14 , B21D35/00 , H01M50/105
CPC分类号: B21D51/16 , B21D26/14 , B21D35/00 , H01M50/105
摘要: A device and method for producing a thin-walled component, in particular a housing film for a pouch cell, from an initial part, comprising a first coil body, an electrical circuit for providing a pulsed electrical current, a die with a support facing the first coil body for the initial part to be reshaped, the support having the shape of the component to be produced, and a first separating device by which a first partial area can be at least partially separated from a second partial area of the initial part, it being possible for the initial part to be arranged between the first coil body and the die, to be accelerated by an electromagnetic force acting between the first coil body and the initial part towards the die and thereby to be deformed by the support and to be at least partially separated by the first separating device.
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公开(公告)号:US12081730B2
公开(公告)日:2024-09-03
申请号:US18591880
申请日:2024-02-29
申请人: Spectralics Ltd.
发明人: Yuval Kashter , Eran Falek , Ran Bar-Yosef
IPC分类号: H04N13/383 , H04N13/32
CPC分类号: H04N13/383 , H04N13/32
摘要: A Dynamic Parallel Monocular Projection (DPMP) system for the provision of dynamically adjusted images to a Head Motion Box (HMB) is provided herein. The DPMP may include a picture generation unit (PGU); a projection unit, further comprising a displaying unit and at least one optical modulator, a Multi-Layered Thin Combiner (MLTC), comprising an infra-red (IR) light source and an IR detection sensor, thereby enabling the provision of images adjusted to the individual location of the observer's eyes within the HMB.
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