公开(公告)号：US11116981B2

公开(公告)日：2021-09-14

申请号：US16217207

申请日：2018-12-12

申请人： Medtronic, Inc.

发明人： Xusheng Zhang ,  Jian Cao

IPC分类号： A61N1/36 ,  A61N1/362 ,  A61N1/37 ,  A61B5/352 ,  A61B5/363 ,  A61N1/39 ,  A61N1/365

摘要： Techniques are described for discriminating SVT and, in particular, rapidly conducting AF. The techniques include detecting an onset of a fast rate of ventricular events sensed from a cardiac electrical signal and detecting a pause in the fast rate of ventricular sensed events. A threshold number of ventricular event intervals required to detect a ventricular tachyarrhythmia is detected with each of the threshold number of ventricular event intervals being less than a tachyarrhythmia detection interval. Detection of the ventricular tachyarrhythmia and an electrical stimulation therapy for treating the ventricular tachyarrhythmia are withheld in response to at least the pause being detected.

公开(公告)号：US11097117B2

公开(公告)日：2021-08-24

申请号：US16283087

申请日：2019-02-22

申请人： Medtronic, Inc.

发明人： Karen J. Kleckner ,  Wade M. Demmer ,  Vincent P. Ganion ,  Yanina Grinberg ,  Paul R. Solheim

IPC分类号： A61N1/378 ,  A61N1/05 ,  A61N1/362 ,  A61N1/365 ,  A61N1/39 ,  A61B5/352 ,  A61B5/361 ,  A61B5/363

摘要： A medical device and method conserve electrical power used in monitoring cardiac arrhythmias. The device includes a sensing circuit configured to sense a cardiac signal, a power source and a control circuit having a processor powered by the power source. The control circuit is configured to operate in a normal state by waking up the processor to analyze the cardiac electrical signal for determining a state of an arrhythmia. The control circuit switches from the normal state to a power saving state that includes waking up the processor at a lower rate than during the normal state.

公开(公告)号：US09888861B2

公开(公告)日：2018-02-13

申请号：US13589270

申请日：2012-08-20

申请人： David L. Carlson ,  Pedram Afshar ,  Timothy J. Denison ,  Jonathon E. Giftakis ,  David E. Linde ,  Scott R. Stanslaski

发明人： David L. Carlson ,  Pedram Afshar ,  Timothy J. Denison ,  Jonathon E. Giftakis ,  David E. Linde ,  Scott R. Stanslaski

IPC分类号： A61B5/04 ,  A61B5/00 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0496

CPC分类号： A61B5/04012 ,  A61B5/04001 ,  A61B5/04014 ,  A61B5/0476 ,  A61B5/0488 ,  A61B5/0496 ,  A61B5/4082 ,  A61B5/4094 ,  A61B5/7264 ,  A61B5/7282

摘要： Various embodiments concern identifying a biomarker in the presence of electrical stimulation. Various embodiments concern delivering electrical stimulation to a patient and sensing one or more signals while the electrical stimulation is being delivered, the one or more signals including data indicative of physiological activity. Various embodiments further include determining an intensity of the electrical stimulation and determining whether the data indicates the presence of a biomarker based on a variable threshold, the variable threshold being variable based on the intensity of the electrical stimulation. Various embodiments concern determining a relationship between stimulation intensity and a biomarker parameter to determine the variability of the variable threshold.

公开(公告)号：US08868173B2

公开(公告)日：2014-10-21

申请号：US13446459

申请日：2012-04-13

申请人： Dwight E. Nelson ,  Rahul Agarwal ,  Steven L. Jensen ,  Rahul Gupta

发明人： Dwight E. Nelson ,  Rahul Agarwal ,  Steven L. Jensen ,  Rahul Gupta

IPC分类号： A61B5/04 ,  A61B5/0476 ,  A61N1/36 ,  A61N1/372 ,  A61B5/0496 ,  A61M5/142 ,  A61N1/05

CPC分类号： A61N1/36139 ,  A61B5/0476 ,  A61B5/0496 ,  A61M5/14276 ,  A61M2005/14208 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36132 ,  A61N1/36153 ,  A61N1/36171 ,  A61N1/36175 ,  A61N1/36185 ,  A61N1/37247

摘要： Various embodiments concern sensing a LFP signal from one or more electrodes, measuring the amplitude of the signals over a period of time, and calculating a plurality of variance values from the amplitude, wherein each of the variance values correspond to the variance of the amplitude for a different interval of time of the period of time with respect to the other variance values. Such embodiments may further include assessing the relative level of neural activation of an area of the brain based on the variance values, wherein the area of the brain is assessed to have a relatively higher level of neural activation when the variance is relatively higher and the area of the brain is assessed to have a relatively lower level of neural activation when the variance is relatively lower.

摘要翻译： 各种实施例涉及感测来自一个或多个电极的LFP信号，在一段时间内测量信号的幅度，以及从幅度计算多个方差值，其中每个方差值对应于幅度的方差 相对于其他方差值的时间段的不同时间间隔。 这样的实施方案可以进一步包括基于方差值评估脑区域的神经激活的相对水平，其中当方差相对较高时评估脑的面积具有相对较高水平的神经激活， 当方差相对较低时，脑的评估具有相对较低水平的神经激活。

公开(公告)号：US08706237B2

公开(公告)日：2014-04-22

申请号：US13766006

申请日：2013-02-13

申请人： Medtronic, Inc.

发明人： Jonathon E. Giftakis ,  Paul H. Stypulkowski ,  Timothy J. Denison ,  Scott R. Stanslaski

IPC分类号： A61N1/36

CPC分类号： A61N1/36146 ,  A61N1/0534 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36139 ,  A61N1/3615 ,  A61N1/36167 ,  A61N1/372

摘要： Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.

摘要翻译： 各种实施例涉及在多个不同水平的刺激参数下向大脑递送电刺激，并且感测脑的生物电响应以递送刺激参数的多个不同级别中的每一个的电刺激。 刺激参数的抑制窗口可以基于感测的生物电响应被识别为具有作为下边界的抑制阈值和放电后阈值作为上边界。 刺激参数的治疗水平可以设置为基于抑制窗口的治疗输送。 刺激参数的治疗水平可以设定为比抑制窗口内的放电后阈值更接近抑制阈值。 提出海马刺激的数据表明抑制窗口。

公开(公告)号：US07141016B2

公开(公告)日：2006-11-28

申请号：US10423594

申请日：2003-04-25

申请人： Michael Lykke ,  Michael Madsen ,  Martin T. Gerber ,  Warren L. Starkebaum

发明人： Michael Lykke ,  Michael Madsen ,  Martin T. Gerber ,  Warren L. Starkebaum

IPC分类号： A61B5/00

CPC分类号： A61B5/14539 ,  A61B5/062 ,  A61B5/07 ,  A61B5/14532 ,  A61B5/4238

摘要： In general, the invention is directed to systems and methods for monitoring the gastrointestinal system of a patient. In one embodiment, the invention includes techniques for monitoring the emptying of the patient's stomach. The techniques may employ glucose monitoring, pH monitoring with a consumable sensor, of monitoring the position of a consumable sensor as it exits the stomach. Consumable sensors may be employed to sense conditions, such as temperature or bile concentration, in other segments of the gastrointestinal system. The invention also includes systems for tracking the position of one or more consumable sensors as the sensors transit the gastrointestinal system, and monitoring the conditions sensed by the sensors.

摘要翻译： 通常，本发明涉及用于监测患者的胃肠系统的系统和方法。 在一个实施例中，本发明包括用于监测患者胃排空的技术。 这些技术可以采用葡萄糖监测，用可消耗传感器进行pH监测，监测消耗型传感器在离开胃时的位置。 可以使用消耗性传感器来检测胃肠系统的其它部分中的条件，例如温度或胆汁浓度。 本发明还包括用于跟踪一个或多个消耗性传感器的位置的系统，因为传感器传送胃肠系统，并监测传感器感测到的状况。

公开(公告)号：US09974901B2

公开(公告)日：2018-05-22

申请号：US14301909

申请日：2014-06-11

申请人： Medtronic, Inc.

发明人： James M. Haase

IPC分类号： A61M1/00 ,  A61M5/142 ,  A61M5/145

CPC分类号： A61M5/14276 ,  A61M5/1452

摘要： An actuator for an infusion drive mechanism comprises a piston defining a first axis and being movable within a passageway of the infusion drive mechanism to convey at least one infusion medium. The passageway defines a longitudinal axis. An armature is connected to the piston and defines at least one cavity configured for disposal of a biasing member engageable with a surface of the infusion drive mechanism to orient the first axis transverse relative to the longitudinal axis. Systems and methods of use are disclosed.

公开(公告)号：US08812098B2

公开(公告)日：2014-08-19

申请号：US13447460

申请日：2012-04-16

申请人： Jonathon E. Giftakis ,  Jianping Wu ,  Dwight E. Nelson

发明人： Jonathon E. Giftakis ,  Jianping Wu ,  Dwight E. Nelson

IPC分类号： A61B5/04 ,  A61B5/00 ,  A61N1/36 ,  A61B5/0476

CPC分类号： A61B5/0476 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/4094 ,  A61B5/4812 ,  A61B5/4836 ,  A61B5/686 ,  A61B5/6868 ,  A61B5/7275 ,  A61N1/36064 ,  A61N1/36135 ,  G06F19/00

摘要： In some examples, systems, devices, and techniques for determining a particular sleep stage of a patient, determining a seizure state of the patient during the particular sleep stage, and generating a seizure probability metric for the particular sleep stage based on the sleep stage and seizure state are described. In some cases, a patient may be more susceptible to seizure events during particular sleep stages. One or more seizure probability metrics indicative of a patient's susceptibility to seizure events during a particular sleep stage may be useful in creating a patient-specific treatment regimen.

摘要翻译： 在一些示例中，用于确定患者的特定睡眠阶段的系统，设备和技术，在特定睡眠阶段确定患者的发作状态，以及基于睡眠阶段产生针对特定睡眠阶段的发作概率度量，以及 描述了发作状态。 在某些情况下，患者在特定睡眠阶段可能更容易发作。 指示患者在特定睡眠阶段期间对发作事件的易感性的一个或多个发作概率指标可用于创建患者特异性治疗方案。

公开(公告)号：US07335197B2

公开(公告)日：2008-02-26

申请号：US10963971

申请日：2004-10-13

申请人： Shahn S. Sage ,  John M. Swoyer ,  Ahmed Elmouelhi ,  Mark A. Christopherson

发明人： Shahn S. Sage ,  John M. Swoyer ,  Ahmed Elmouelhi ,  Mark A. Christopherson

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B18/1477 ,  A61B2017/00274 ,  A61B2018/00005 ,  A61B2018/00547 ,  A61B2018/00988 ,  A61B2018/1425 ,  A61B2018/1475

摘要： A one-piece, single-use disposable device for transurethral needle ablation (TUNA) of prostate tissue to alleviate BPH is disclosed. The device may include a flexible catheter tip including a rigid core and a flexible tip. The device may also include a single use lockout to help ensure that the device is used to perform only one ablation procedure on a single patient. The device may further include a simplified needle deployment mechanism and/or an automatic needle retraction mechanism.

摘要翻译： 公开了一种用于经尿道针消融（TUNA）的前列腺组织以缓解BPH的单件式一次性一次性装置。 该装置可以包括柔性导管尖端，其包括刚性芯和柔性尖端。 该装置还可以包括单次使用锁定，以帮助确保该装置仅用于在单个患者上执行一个消融程序。 该装置还可以包括简化的针展开机构和/或自动针回缩机构。

公开(公告)号：US07254448B2

公开(公告)日：2007-08-07

申请号：US10657047

申请日：2003-09-05

申请人： Allen Dale Almendinger ,  Martinus A G M Bakx

发明人： Allen Dale Almendinger ,  Martinus A G M Bakx

IPC分类号： A61N1/08

CPC分类号： A61N1/3727 ,  A61B5/0031 ,  A61B5/4839 ,  A61M2205/3523 ,  A61N1/08 ,  H04R2225/67 ,  Y10S128/903

摘要： An implantable medical device with a main processor also has a telemetry processor to perform some telemetry processing functions resulting under some circumstances in reducing demands on the main processor, conserving energy, increasing telemetry processing speed, and many other advantages. A wide variety of implantable medical devices can be configured with a telemetry processor including neuro stimulators, pacemakers, defibrillators, drug delivery pumps, diagnostic recorders, and cochlear implants. The telemetry processor includes control logic, a data decoder, a receive buffer, a data encoder, and a transmit buffer. Methods of receiving messages and transmitting messages with a telemetry processor are also disclosed.

摘要翻译： 具有主处理器的可植入医疗装置还具有遥测处理器，以在某些情况下执行一些遥测处理功能，以减少对主处理器的需求，节省能量，提高遥测处理速度以及许多其他优点。 各种可植入医疗装置可以配置有包括神经刺激器，起搏器，除颤器，药物输送泵，诊断记录器和人工耳蜗的遥测处理器。 遥测处理器包括控制逻辑，数据解码器，接收缓冲器，数据编码器和发送缓冲器。 还公开了使用遥测处理器接收消息和发送消息的方法。