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公开(公告)号：US20230166111A1
公开(公告)日：2023-06-01
申请号：US18051421
申请日：2022-10-31
申请人： Medtronic, Inc.
发明人： Kristin N. Hageman , Scott R. Stanslaski , Erik J. Peterson , Rene A. Molina , Paul H. Stypulkowski , David A. Dinsmoor , Leonid M. Litvak , Michelle A. Case
CPC分类号： A61N1/36139 , A61N1/0534 , A61N1/36146
摘要： A system includes memory and processing circuitry coupled to the memory and configured to determine a plurality of local field potential (LFP) measurements of an LFP, wherein the LFP is intrinsically generated by a signal source within a brain of a patient, determine one or more electrodes for delivering a therapeutic electrical stimulation signal based on the LFP measurements, control stimulation generation circuitry to deliver a plurality of electrical stimulation signals via the determined one or more electrodes, wherein the plurality of electrical stimulation signals each comprise at least one different therapy parameter, for respective ones of the plurality of electrical stimulation signals, determine respective evoked signals, wherein the respective evoked signals are evoked by delivery of the respective plurality of electrical stimulation signals, and determine at least one parameter for the therapeutic electrical stimulation signal based on the respective evoked signals.
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公开(公告)号：US10729908B2
公开(公告)日：2020-08-04
申请号：US16036439
申请日：2018-07-16
申请人： Medtronic, Inc.
摘要： Deep Brain Stimulation (DBS) electrodes are positioned within (or adjacent to) white matter fiber tracts in a brain of patient. The DBS electrodes may be positioned near one or more stimulation sites within the white matter fiber tracts. The stimulation sites may be selected based on the disorder of the patient. In some examples, the stimulation sites may be selected based on one or more symptoms of the patient. In some examples, additional electrodes may be positioned in another area to collect bioelectrical brain signals. The area in which the additional electrodes are placed is an area that is different from the stimulation site but is targeted by stimulation therapy provided at the stimulation site.
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公开(公告)号：US20140180358A1
公开(公告)日：2014-06-26
申请号：US14194026
申请日：2014-02-28
申请人： MEDTRONIC, INC.
IPC分类号： A61N1/36
CPC分类号： A61N1/36146 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36139 , A61N1/3615 , A61N1/36167 , A61N1/372
摘要： Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.
摘要翻译： 各种实施例涉及在多个不同水平的刺激参数下向大脑递送电刺激，并且感测脑的生物电响应以递送刺激参数的多个不同级别中的每一个的电刺激。 刺激参数的抑制窗口可以基于感测的生物电响应被识别为具有作为下边界的抑制阈值和放电后阈值作为上边界。 刺激参数的治疗水平可以设置为基于抑制窗口的治疗输送。 刺激参数的治疗水平可以设定为比抑制窗口内的放电后阈值更接近抑制阈值。 提出海马刺激的数据表明抑制窗口。
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公开(公告)号：US20130218232A1
公开(公告)日：2013-08-22
申请号：US13766006
申请日：2013-02-13
申请人： Medtronic, Inc.
IPC分类号： A61N1/372
CPC分类号： A61N1/36146 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36139 , A61N1/3615 , A61N1/36167 , A61N1/372
摘要： Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.
摘要翻译： 各种实施例涉及在多个不同水平的刺激参数下向大脑递送电刺激，并且感测脑的生物电响应以递送刺激参数的多个不同级别中的每一个的电刺激。 刺激参数的抑制窗口可以基于感测的生物电响应被识别为具有作为下边界的抑制阈值和放电后阈值作为上边界。 刺激参数的治疗水平可以设置为基于抑制窗口的治疗输送。 刺激参数的治疗水平可以设定为比抑制窗口内的放电后阈值更接近抑制阈值。 提出海马刺激的数据表明抑制窗口。
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公开(公告)号：US09724517B2
公开(公告)日：2017-08-08
申请号：US14194026
申请日：2014-02-28
申请人： MEDTRONIC, INC.
CPC分类号： A61N1/36146 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36139 , A61N1/3615 , A61N1/36167 , A61N1/372
摘要： Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.
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公开(公告)号：US11925806B2
公开(公告)日：2024-03-12
申请号：US16941085
申请日：2020-07-28
申请人： Medtronic, Inc.
CPC分类号： A61N1/36139 , A61N1/0534 , A61N1/36082 , A61N1/36096 , A61N1/36171
摘要： Deep Brain Stimulation (DBS) electrodes are positioned within (or adjacent to) white matter fiber tracts in a brain of patient. The DBS electrodes may be positioned near one or more stimulation sites within the white matter fiber tracts. The stimulation sites may be selected based on the disorder of the patient. In some examples, the stimulation sites may be selected based on one or more symptoms of the patient. In some examples, additional electrodes may be positioned in another area to collect bioelectrical brain signals. The area in which the additional electrodes are placed is an area that is different from the stimulation site but is targeted by stimulation therapy provided at the stimulation site.
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公开(公告)号：US11077305B2
公开(公告)日：2021-08-03
申请号：US15699873
申请日：2017-09-08
申请人： MEDTRONIC, INC.
发明人： Jonathon E. Giftakis , Timothy J. Denison , Paul H. Stypulkowski , Scott R. Stanslaski , Robert S. Raike , Mae Eng , David E. Linde , Thomas Adamski
摘要： In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.
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公开(公告)号：US20180326217A1
公开(公告)日：2018-11-15
申请号：US16036439
申请日：2018-07-16
申请人： Medtronic, Inc.
CPC分类号： A61N1/36139 , A61N1/0534 , A61N1/36082 , A61N1/36096 , A61N1/36171
摘要： Deep Brain Stimulation (DBS) electrodes are positioned within (or adjacent to) white matter fiber tracts in a brain of patient. The DBS electrodes may be positioned near one or more stimulation sites within the white matter fiber tracts. The stimulation sites may be selected based on the disorder of the patient. In some examples, the stimulation sites may be selected based on one or more symptoms of the patient. In some examples, additional electrodes may be positioned in another area to collect bioelectrical brain signals. The area in which the additional electrodes are placed is an area that is different from the stimulation site but is targeted by stimulation therapy provided at the stimulation site.
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公开(公告)号：US20140194945A1
公开(公告)日：2014-07-10
申请号：US14207926
申请日：2014-03-13
申请人： Medtronic, Inc.
IPC分类号： A61N1/36
CPC分类号： A61N1/36064 , A61N1/0534 , A61N1/36135 , A61N1/36171 , A61N1/36185
摘要： In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.
摘要翻译： 在选择用于治疗患者状况的靶治疗递送部位的一些实例中，相对高频率的电刺激信号被递送到患者脑部的第一区域（例如，丘脑的前核）内的至少两个区域 并且确定响应于递送的刺激的患者脑的第二区域（例如，海马）中的脑活动（例如，由生物电脑信号所示）的变化。 可以基于脑活动的变化来选择靶治疗递送部位，电极组合或两者。
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公开(公告)号：US08706237B2
公开(公告)日：2014-04-22
申请号：US13766006
申请日：2013-02-13
申请人： Medtronic, Inc.
IPC分类号： A61N1/36
CPC分类号： A61N1/36146 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36139 , A61N1/3615 , A61N1/36167 , A61N1/372
摘要： Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.
摘要翻译： 各种实施例涉及在多个不同水平的刺激参数下向大脑递送电刺激，并且感测脑的生物电响应以递送刺激参数的多个不同级别中的每一个的电刺激。 刺激参数的抑制窗口可以基于感测的生物电响应被识别为具有作为下边界的抑制阈值和放电后阈值作为上边界。 刺激参数的治疗水平可以设置为基于抑制窗口的治疗输送。 刺激参数的治疗水平可以设定为比抑制窗口内的放电后阈值更接近抑制阈值。 提出海马刺激的数据表明抑制窗口。
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