公开(公告)号：US20230045737A1

公开(公告)日：2023-02-09

申请号：US17299761

申请日：2019-12-05

Applicant: Vividion Therapeutics, Inc.

Inventor： Robert HUBBARD ,  Betty LAM ,  Shota KIKUCHI ,  Flora HUYNH ,  Chung-Mao PAN ,  Dan BEISNER ,  Eric ALLEN

IPC: C07D401/14 ,  C07D401/04

Abstract: Disclosed herein are isoindolinone compounds and methods for binding cereblon and for modulating cereblon neosubstrates. The isoindolinone compounds can have a structure of Formula (I).

公开(公告)号：US20250026721A1

公开(公告)日：2025-01-23

申请号：US18589169

申请日：2024-02-27

Applicant: Vividion Therapeutics, Inc.

Inventor： Junko TAMIYA ,  Benjamin HORNING ,  Karl BEDKE ,  Cynthia BERRY ,  Chung-Mao PAN ,  Hideki Miyatake ONDOZABAL ,  Brian COOK

IPC: C07D211/96 ,  A61K31/4025 ,  A61K31/445 ,  A61K31/4523 ,  A61K31/453 ,  A61K31/4535 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/55 ,  C07D211/62 ,  C07D211/78 ,  C07D223/06 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14

Abstract: Compounds and methods for modulating RAS-PI3K.

公开(公告)号：US20240067612A1

公开(公告)日：2024-02-29

申请号：US18218149

申请日：2023-07-05

Applicant: Vividion Therapeutics, Inc.

Inventor： Shota Kikuchi ,  Betty Lam ,  Jason Green ,  Don Rogness ,  David Weinstein ,  Larry Burgess ,  Benjamin Horning ,  Kelsey Lamb ,  Zach Owyang ,  Robert Malmstrom

IPC: C07D239/34 ,  C07D403/06 ,  C07K14/00 ,  A61P35/00

CPC classification number: C07D239/34 ,  C07D403/06 ,  C07K14/001 ,  A61P35/00

Abstract: Disclosed are compounds of Formula (I):






or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

公开(公告)号：US20240270705A1

公开(公告)日：2024-08-15

申请号：US18563329

申请日：2022-05-25

Applicant: Vividion Therapeutics, Inc.

Inventor： Benjamin HORNING ,  Nilotpal ROY ,  Matthew PATRICELLI ,  Betty LAM ,  Shota KIKUCHI ,  Brian Nicholas COOK

IPC: C07D265/30 ,  A61K31/40 ,  A61K31/444 ,  A61K31/4525 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/55 ,  C07D207/08 ,  C07D211/18 ,  C07D211/38 ,  C07D211/42 ,  C07D211/44 ,  C07D223/04 ,  C07D241/04 ,  C07D401/04 ,  C07D401/06 ,  C07D405/06 ,  C12N9/12

CPC classification number: C07D265/30 ,  A61K31/40 ,  A61K31/444 ,  A61K31/4525 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506 ,  A61K31/5375 ,  A61K31/55 ,  C07D207/08 ,  C07D211/18 ,  C07D211/38 ,  C07D211/42 ,  C07D211/44 ,  C07D223/04 ,  C07D241/04 ,  C07D401/04 ,  C07D401/06 ,  C07D405/06 ,  C12N9/1205

Abstract: Disclosed herein are compounds selective for JAK1, pharmaceutical compositions comprising said compounds, and methods of using said compounds.

公开(公告)号：US20240140915A1

公开(公告)日：2024-05-02

申请号：US18370519

申请日：2023-09-20

Applicant: Vividion Therapeutics, Inc.

Inventor： Shota Kikuchi ,  Betty Lam ,  Jason Green ,  Don Rogness ,  David Weinstein ,  Larry Burgess ,  Benjamin Horning ,  Kelsey Lamb ,  Zachary Owyang ,  Robert Malmstrom

IPC: C07D239/34 ,  A61P35/00 ,  C07D403/06 ,  C07K14/00

CPC classification number: C07D239/34 ,  A61P35/00 ,  C07D403/06 ,  C07K14/001

Abstract: Disclosed are compounds of Formula (I):




or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

公开(公告)号：US20250011291A1

公开(公告)日：2025-01-09

申请号：US18742689

申请日：2024-06-13

Applicant: Vividion Therapeutics, Inc.

Inventor： Karl BEDKE ,  Jason GREEN ,  Fabian GOERICKE ,  Shota KIKUCHI ,  Donald C. ROGNESS ,  David WEINSTEIN ,  Michael WALLACE ,  Zach OWYANG

IPC: C07D257/04 ,  A61K31/41 ,  A61K31/4545 ,  A61K31/506 ,  C07D213/61 ,  C07D239/47

Abstract: Compounds and methods for activating Nrf2 by inhibiting KEAP1.

公开(公告)号：US20220298213A1

公开(公告)日：2022-09-22

申请号：US17750833

申请日：2022-05-23

Applicant: Vividion Therapeutics, Inc. ,  The Scripps Research Institute

Inventor： David WEINSTEIN ,  Benjamin F. CRAVATT ,  Matthew PATRICELLI ,  Dean STAMOS ,  Gabe SIMON ,  Benjamin HORNING ,  Ekaterina VINOGRADOVA ,  Brian NORDIN ,  Kristen BALTGALVIS ,  Todd KINSELLA

IPC: C07K14/47 ,  C07D211/94

Abstract: Disclosed herein are in vivo engineered cereblon protein and methods of making the same. The in vivo engineered cereblon protein can include a site-specific non-naturally occurring modification at cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO: 2 or 3, the modification comprising a moiety resulting from an in vivo Michael addition reaction between an exogenous Michael acceptor and the cysteine 287 as set forth in SEQ ID NO: 1, or cysteine 286 as set forth in SEQ ID NO: 2 or 3.

公开(公告)号：US10781239B2

公开(公告)日：2020-09-22

申请号：US16536227

申请日：2019-08-08

Applicant: Vividion Therapeutics, Inc. ,  The Scripps Research Institute

Inventor： David Weinstein ,  Benjamin F. Cravatt ,  Matthew Patricelli ,  Dean Stamos ,  Gabe Simon ,  Benjamin Horning ,  Ekaterina Vinogradova ,  Brian Nordin ,  Kristen Baltgalvis ,  Todd Kinsella

IPC: C07K14/47 ,  C07D211/94

Abstract: Disclosed herein are in vivo engineered cereblon protein and methods of making the same. The in vivo engineered cereblon protein can include a site-specific non-naturally occurring modification at cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO:2 or 3, the modification comprising a moiety resulting from an in vivo Michael addition reaction between an exogenous Michael acceptor and the cysteine 287 as set forth in SEQ ID NO:1, or cysteine 286 as set forth in SEQ ID NO:2 or 3.

公开(公告)号：US20250059161A1

公开(公告)日：2025-02-20

申请号：US18593361

申请日：2024-03-01

Applicant: Vividion Therapeutics, Inc.

Inventor： Qingfeng WU ,  Brian COOK ,  Michael WALLACE ,  Jonathan POLLACK ,  Aaron SNEAD ,  Bryan LEE ,  Robert MALMSTROM ,  Gabriel HAMMERSLEY ,  Mariangela URBANO ,  Jason GREEN ,  Philip ALABI

IPC: C07D401/14 ,  A61K31/4402 ,  A61K31/4745 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/506 ,  C07B59/00 ,  C07D401/06 ,  C07D401/12 ,  C07D405/14 ,  C07D487/04 ,  C07D519/00

Abstract: Compounds and methods for inhibiting STAT3.

公开(公告)号：US12187685B2

公开(公告)日：2025-01-07

申请号：US18370519

申请日：2023-09-20

Applicant: Vividion Therapeutics, Inc.

Inventor： Shota Kikuchi ,  Betty Lam ,  Jason Green ,  Don Rogness ,  David Weinstein ,  Larry Burgess ,  Benjamin Horning ,  Kelsey Lamb ,  Zachary Owyang ,  Robert Malmstrom

IPC: C07D237/34 ,  A61P35/00 ,  C07D239/34 ,  C07D403/06 ,  C07K14/00

Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.