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公开(公告)号:US20180256710A1
公开(公告)日:2018-09-13
申请号:US15759362
申请日:2016-09-13
申请人: UNIVERSITÉ LAVAL
IPC分类号: A61K39/395 , C07K16/18 , A61P35/02
CPC分类号: A61K39/3955 , A61K31/351 , A61K31/513 , A61K39/395 , A61K2039/505 , A61K2300/00 , A61P35/02 , C07K16/18 , C07K16/24
摘要: The present description relates to an anti-S1008 protein for treating leukemia. More specifically, is disclosed anti-S100A8 antibody that specifically binds to a portion of S100A8 protein and/or a S100A8/S100A9 heterodimer for treating leukemia.
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公开(公告)号:US20240287127A1
公开(公告)日:2024-08-29
申请号:US18571556
申请日:2022-06-16
申请人: UNIVERSITÉ LAVAL
CPC分类号: C07J73/005 , A61K31/58 , A61K45/06 , A61P35/00
摘要: Novel chemical agents are described herein. More specifically, a novel inhibitor of 17β-HSD7 for decreasing estradiol concentrations while restoring dihydrotestosterone (DHT) concentrations in breast cancer cells is disclosed herein. In a particular embodiment, the inhibitor of 17β-HSD7 has the following structure: (Formula I) A process for producing the novel inhibitors of 17β-HSD7 and their use in the manufacture of pharmaceutical formulations and/or combinations is also disclosed.
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公开(公告)号:US20240230929A1
公开(公告)日:2024-07-11
申请号:US18558665
申请日:2022-05-03
申请人: Université Laval , Medscint Inc.
CPC分类号: G01T1/1603 , G01T1/2002 , G01T1/22 , G01T7/005
摘要: According to some aspects, a detector includes a sensing volume of Cerenkov generating material that is configured to sense charged particles with different angles and energies in response to irradiation and to emit a spectral and angular distribution of Cerenkov optical light indicative of an angular and energy distribution of incoming charged particles sensed by the volume of Cerenkov generating material.
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公开(公告)号:US11916348B2
公开(公告)日:2024-02-27
申请号:US16943713
申请日:2020-07-30
CPC分类号: H01S3/06729 , H01S3/06712 , H01S3/06716 , H01S3/06754 , H01S3/1608 , G02B6/024 , G02B6/02285 , G02B6/03627
摘要: An optical fiber comprises a core having an elliptical cross section and a cladding having a circular cross section. The core has an aspect ratio between 2 and 40. The core and the cladding have a common central axis with the core being enclosed by the cladding. The difference of a refractive index of the cladding to a refractive index of the core is between 1×10−2 and 1.5×10−1. A trench is located between the core and the cladding. The trench has a uniform width and encircles the core. The refractive index of the trench is lower than the refractive index of the cladding.
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公开(公告)号:US20230408532A1
公开(公告)日:2023-12-21
申请号:US18306992
申请日:2023-09-05
申请人: UNIVERSITÉ LAVAL
发明人: Francesca Cicchetti , Eric Boilard
CPC分类号: G01N33/6896 , C12Q1/32 , C12Q1/34 , G01N1/28 , G01N33/5076 , G01N33/573
摘要: The present description relates to methods for clinically assessing Parkinson's disease in a subject using protein biomarkers of erythrocyte-derived extracellular vesicles (EEV).
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公开(公告)号:US11662352B2
公开(公告)日:2023-05-30
申请号:US16484073
申请日:2018-02-09
申请人: Université Laval
发明人: Francesca Cicchetti , Eric Boilard
CPC分类号: G01N33/6896 , C12Q1/32 , C12Q1/34 , G01N1/28 , G01N33/5076 , G01N33/573
摘要: The present description relates to methods for clinically assessing Parkinson's disease in a subject using protein biomarkers of erythrocyte-derived extracellular vesicles (EEV).
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公开(公告)号:US20230163553A1
公开(公告)日:2023-05-25
申请号:US17919553
申请日:2021-04-21
申请人: UNIVERSITÉ LAVAL , CEGEP GARNEAU
IPC分类号: H01S3/067 , H01S3/094 , H01S3/0941 , H01S3/1112
CPC分类号: H01S3/0675 , H01S3/094003 , H01S3/09415 , H01S3/1112 , H01S3/06791
摘要: There is described a fiber laser system generally having a pump laser generating a pump laser beam; and a length of optical fiber optically coupled to the pump laser, the length of optical fiber having: a laser cavity having a cavity path, a first fiber Bragg grating having a first reflectivity profile, a second filter having a second filter profile, and an optical gain region between the first fiber Bragg grating and the second filter along the cavity path, the first reflectivity profile being spectrally detuned from the second filter profile, the first fiber Bragg grating having a first refractive index profile comprising a full width at half maximum bandwidth of at least 0.2 nm and a Gaussian-like apodization, wherein, upon pumping of the optical gain region with the pump laser beam and mode locking of the laser cavity, optical pulses are circulated along the cavity path; and an output.
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公开(公告)号:US20230002457A1
公开(公告)日:2023-01-05
申请号:US17782869
申请日:2020-12-04
发明人: Loïc Henaux , André Marette , Laurent Bazinet
摘要: Novel peptides and their uses are provided. In particular, the peptides are useful for increasing glucose uptake or decreasing hepatic glucose production. The peptides are also useful for regulating glucose levels and/or treating diabetes in a subject.
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公开(公告)号:US20220026477A1
公开(公告)日:2022-01-27
申请号:US16936589
申请日:2020-07-23
申请人: UNIVERSITÉ LAVAL
IPC分类号: G01R29/027 , G01R19/04 , A61B5/024 , A61B5/00
摘要: There is described a method of associating a pulsed signal to a corresponding reference pulse shape. The method generally has accessing reference data having a plurality of reference pulse shapes, each reference pulse shape having a sparse array of average coefficients; receiving a pulsed signal having an array of amplitude values, including generating a sparse array of instantaneous coefficients based on said pulsed signal for example using a discrete wavelet transform; calculating a plurality of first distances between said instantaneous coefficients of said sparse array and the average coefficients of each one of said reference pulse shapes, said first distances having a first minimal distance identifying a closer one of the reference pulse shapes; and upon determining that said first minimal distance is below a first distance threshold, associating said sparse array of instantaneous coefficients to the closer one of the reference pulse shapes.
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公开(公告)号:US20210290753A1
公开(公告)日:2021-09-23
申请号:US17261055
申请日:2019-11-08
申请人: UNIVERSITÉ LAVAL
发明人: Gary KOBINGER , George BABUADZE
摘要: The present disclosure relates to DNA vaccines against Crimean-Congo Hemorrhagic Fever (CCHF) virus. The present disclosure also relates to CCHF virus sequences and their use for vaccination such as DNA vaccination. The present disclosure more particularly relates to artificial nucleic acid molecules that are able to encode a CCHF polypeptide of an infectious CCHF virus, a fragment or a variant thereof. The nucleic acid molecules of the present application are formulated as immunogenic compositions.
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