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公开(公告)号：US20190064166A1
公开(公告)日：2019-02-28
申请号：US15752230
申请日：2016-08-12
IPC分类号： G01N33/573 , G01N33/68 , G01N33/70
摘要： The present invention provides methods for treatment of volume-dependent Acute Kidney Injury (vAKI) and ischemic Acute Kidney Injury (iAKI), as well as methods for diagnosing vAKI and iAKI. The methods are based on determining the levels of PAPPA2, NGAL, KRT20, or TAC-STD2 protein in a sample from a patient, such as a urine sample. The present invention also provides a device and a diagnostics kit for determining whether a sample from a subject contains PAPPA2, NGAL, KRT20, or TACSTD2 protein.
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公开(公告)号：US20230137331A1
公开(公告)日：2023-05-04
申请号：US17839397
申请日：2022-06-13
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： Michael C. Milone , Lance C. Kam , Keyue Shen , Xueli Hao , Roderick O'Connor , Geraldine Goebrecht
IPC分类号： A61K35/17 , C12N5/0783 , C07K16/28
摘要： The present invention provides compositions and methods for activation and expansion of T cells using a biocompatible solid substrate with tunable rigidity. Rigidity of a substrate is an important parameter that can be used to control the overall expansion and differentiation of T cells.
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公开(公告)号：US20230131820A1
公开(公告)日：2023-04-27
申请号：US17967598
申请日：2022-10-17
申请人： The Curators of the University of Missouri , The Trustees of Columbia University in the City of New York
发明人： James L. Cook , Clark T. Hung , Eric Lima , Aaron Stoker
IPC分类号： A01N1/02
摘要： The present invention provides a method and apparatus for tissue, such as an allograft, storage and preservation for extended periods of time at room temperature in a sterile tissue culture chamber. The invention further provides a process for maintaining the sterility of tissue using the apparatus as described.
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公开(公告)号：US20230128716A1
公开(公告)日：2023-04-27
申请号：US17882938
申请日：2022-08-08
发明人： WEI MIN , LU WEI , ZHIXING CHEN , FANGHAO HU , YIHUI SHEN
摘要： Methods, systems and computer-accessible medium for imaging a living cell or a living organism with bond-edited compounds using stimulated Raman scattering are disclosed. The method comprises the steps of introducing one or more bond-edited compounds into a live cell or a living organism, and detecting a vibrational tag in the cell or organism with stimulated Raman scattering. Also disclosed are methods for detecting a disease condition in a subject, methods for monitoring treatment for a disease condition, methods for screening an agent, methods for tracing a cellular process in a live cell using bond-edited compounds in combination with stimulated Raman scattering. Also disclosed are a composition for labeling a target cell with at least one bond-edited compound and devices for imaging bond-edited compounds by stimulated Raman scattering.
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公开(公告)号：US11624727B2
公开(公告)日：2023-04-11
申请号：US14837514
申请日：2015-08-27
IPC分类号： G01N27/447 , B82Y5/00 , C12Q1/6869 , B82Y15/00 , G01N33/68 , G01N33/487
摘要： A system and method for detecting a single-molecule using an integrated circuit which includes at least one membrane having a nanopore located between first and second reservoirs and a low-noise preamplifier having an electrode formed on the surface thereof is provided. The method includes passing a target molecule through the nanopore, and measuring a current through the nanopore to detect the presence of a biomolecular entity, if any.
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6.发明授权公开(公告)号：US11622948B2
公开(公告)日：2023-04-11
申请号：US16761548
申请日：2018-11-08
申请人： The Trustees of Columbia University in the City of New York , Berg LLC , THE RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.
IPC分类号： A61K31/135 , A61P25/22 , A61P25/24 , A61K9/00
摘要： Biomarkers for assessing the efficacy of prophylactic treatments of stress-induced affective disorders are provided.
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公开(公告)号：US11617900B2
公开(公告)日：2023-04-04
申请号：US17182601
申请日：2021-02-23
摘要： Certain exemplary embodiments can provide an apparatus and method for generating at least one radiation. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range.
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公开(公告)号：US20230096831A1
公开(公告)日：2023-03-30
申请号：US17994826
申请日：2022-11-28
申请人： The Trustees of Columbia University in the City of New York , Research Foundation for Mental Hygiene, Inc.
发明人： Daniel JAVITT , Marta MORENO
摘要： Exemplary system, method, and computer-accessible medium for determining a position or a characteristic of a target(s) for a transcranial magnetic stimulation (TMS) treatment of a patient(s) can be provided. For example, it is possible to, for example, receive imaging information of a portion(s) of a head of the patient(s), and determine the position or the characteristic of the target(s) for the TMS treatment of the patient(s) based on the imaging information. The imaging information can be magnetic resonance imaging information. The imaging information can include information regarding a brain and a skull of the patient(s). The position or the characteristic of the target(s) can be determined by identifying (i) the skull, and (ii) a parcel in a section(s) of a brain of the patient(s). The parcel can a dorsolateral prefrontal cortex (DLPFC) parcel. The DLPFC parcel can be identified using a parcellation procedure, which can be a human connectome pipeline procedure.
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公开(公告)号：US11613784B2
公开(公告)日：2023-03-28
申请号：US16072825
申请日：2017-03-16
IPC分类号： C12Q1/6886
摘要： The present invention provides methods of detecting ultraviolet radiation (UVR)-induced skin damage in a subject. The method includes the steps of: a) obtaining a skin sample from the subject; b) analyzing expression levels in the skin sample of UVR-induced differentially expressed genes (DEGs) listed in Table 8 or a subset thereof; and c) comparing the expression levels of the UVR-induced DEGs to a control skin sample; wherein, when the expression levels of the UVR-induced DEGs in the skin sample is above or below the level of each of the UVR-induced DEGs in the control sample, the subject is identified as likely being afflicted with UVR-induced skin damage. Also provided are methods for measuring the effectiveness of a test agent in reducing ultraviolet radiation (UVR)-induced damage.
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公开(公告)号：US11607558B2
公开(公告)日：2023-03-21
申请号：US17177928
申请日：2021-02-17
摘要： Certain exemplary embodiments can provide an apparatus and method for generating at least one radiation. The exemplary apparatus and/or method can selectively kill and/or affect at least one bacteria. For example, a radiation source first arrangement can be provided which is configured to generate at least one radiation having one or more wavelengths provided in a range of about 190 nanometers (nm) to about 230 nm, and at least one second arrangement can be provided which is configured to prevent the at least one radiation from having any wavelength that is outside of the range.
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