公开(公告)号：US20230285505A1

公开(公告)日：2023-09-14

申请号：US18007264

申请日：2021-06-24

申请人： SUSAVION BIOSCIENCES, INC.

发明人： Laura L. Eggink ,  J. Kenneth Hoober

IPC分类号： A61K38/10 ,  A61K39/395 ,  A61K31/573 ,  A61P17/00

CPC分类号： A61K38/10 ,  A61K39/3955 ,  A61K31/573 ,  A61P17/00

摘要： The present invention provides a method of treating pathological inflammation in a patient comprising: administering to the patient a multivalent structured polypeptide comprising multiple copies of the therapeutic peptide. The present invention also provides a kit, comprising: a multivalent structured polypeptide comprising multiple copies of the therapeutic peptide; and instructions teaching administration of the multivalent structured polypeptide to a patient having atopic dermatitis.

公开(公告)号：USRE47245E1

公开(公告)日：2019-02-19

申请号：US15278016

申请日：2016-09-27

申请人： Susavion Biosciences, Inc.

发明人： Laura L. Eggink ,  J. Kenneth Hoober

IPC分类号： C07K7/06 ,  C07K14/00

摘要： This present invention is directed to peptides, compositions, and methods for modulating endogenous cytokine expression in a subject. More specifically, the invention provides peptides useful in regulating the release of a specific pattern of cytokines that promote angiogenesis and/or can be used to modulate the immune system of a subject.

公开(公告)号：US20220331394A1

公开(公告)日：2022-10-20

申请号：US17850976

申请日：2022-06-27

申请人： SUSAVION BIOSCIENCES, INC.

发明人： Laura L. Eggink ,  J. Kenneth Hoober

IPC分类号： A61K38/08 ,  A61K47/55 ,  A61P35/00 ,  A61K31/7084 ,  A61K47/64 ,  A61K47/65 ,  A61K38/10

摘要： The present disclosure relates to pharmaceutical compositions comprising a peptide or multivalent polypeptide, and an anti-cancer agent. In some embodiments, the anti-cancer agent is conjugated to the peptide or multivalent polypeptide. The present disclosure also relates to a method of treating cancer or reducing cancer cell proliferation using the peptide or multivalent polypeptide. In some aspects, the peptide or multivalent polypeptide enhances the efficacy of the anti-cancer agent, the targeting of the anti-cancer agent to the cancer cells, or both.

公开(公告)号：US20140155313A1

公开(公告)日：2014-06-05

申请号：US14097215

申请日：2013-12-04

申请人： SUSAVION BIOSCIENCES, INC.

发明人： Laura L. Eggink ,  J. Kenneth Hoober

IPC分类号： A61K47/48 ,  A61K38/02

CPC分类号： A61K47/48176 ,  A61K38/02 ,  A61K38/08 ,  A61K47/48784 ,  A61K47/58 ,  A61K47/6903 ,  A61L15/32 ,  C07K1/1133

摘要： The present invention provides methods of synthesizing hydrogels that contain covalently linked polypeptides. These polypeptides may be tetravalent peptides or polypeptides that bind to cell surface receptors. The hydrogels synthesized by the methods of the present invention may be used in wound dressings or applied directly to wounds to promote healing.

摘要翻译： 本发明提供合成含有共价连接多肽的水凝胶的方法。 这些多肽可以是结合细胞表面受体的四价肽或多肽。 通过本发明的方法合成的水凝胶可以用于伤口敷料中或直接施加到伤口上以促进愈合。

公开(公告)号：US08460697B2

公开(公告)日：2013-06-11

申请号：US12823556

申请日：2010-06-25

申请人： Laura L. Eggink ,  J. Kenneth Hoober

发明人： Laura L. Eggink ,  J. Kenneth Hoober

IPC分类号： A61K38/08 ,  C07K7/06

CPC分类号： C07K14/001 ,  C07K7/06

摘要： This present invention is directed to peptides, compositions, and methods for modulating endogenous cytokine expression in a subject. More specifically, the invention provides peptides useful in regulating the release of a specific pattern of cytokines that promote angiogenesis and/or can be used to modulate the immune system of a subject.

摘要翻译： 本发明涉及用于调节受试者内源性细胞因子表达的肽，组合物和方法。 更具体地，本发明提供了可用于调节促进血管生成和/或可用于调节受试者的免疫系统的细胞因子的特定模式的释放的肽。

公开(公告)号：US10350260B2

公开(公告)日：2019-07-16

申请号：US15569753

申请日：2015-07-08

申请人： SUSAVION BIOSCIENCES, INC.

发明人： Laura L. Eggink ,  J. Kenneth Hoober

IPC分类号： A61K38/08 ,  A61K39/395 ,  A61P35/00 ,  A61P31/12 ,  A61P37/02 ,  A61K45/00 ,  A61K45/06 ,  A61K39/00

摘要： The methods and compounds disclosed herein are useful in treating a subject having cancer or a viral infection by modulating the innate and adaptive immune systems typically by both inhibiting the function of inhibitory receptors and enhancing activity of activating receptors. Preferred therapeutic compositions comprise a carrier; at least one agent selected from the group consisting of: an anti-inflammatory agent, a cytotoxic T cell proliferation agent, or a NK cell proliferation agent; and a therapeutic peptide of the invention. In certain embodiments the compositions further include a second therapeutic peptide and/or an immunoglobulin admixed therewith in an amount sufficient to enhance passive immunoprotection in the subject.

公开(公告)号：US09981044B2

公开(公告)日：2018-05-29

申请号：US15507639

申请日：2015-08-31

申请人： Susavion Biosciences, Inc.

发明人： Laura L. Eggink ,  J. Kenneth Hoober

IPC分类号： A61K38/08 ,  A61K47/65 ,  A61K47/48 ,  C07K14/47 ,  C07K14/52 ,  A61K38/19 ,  G01N33/574 ,  A61K47/64 ,  A61K38/00 ,  A61K39/00 ,  C07K19/00

CPC分类号： A61K47/641 ,  A61K38/00 ,  A61K38/08 ,  A61K38/19 ,  A61K39/00 ,  A61K47/48246 ,  A61K47/65 ,  C07K14/47 ,  C07K14/52 ,  C07K19/00 ,  C07K2319/02 ,  G01N33/574

摘要： Polypeptides, such as a multi-valent polypeptide designated svD2, useful in pharmaceutical compositions for stimulation of the adaptive arm of the immune system. svD2 demonstrated in vivo activity in a syngeneic mouse model. svD2 is biologically active at nanomolar concentrations. These properties are believed to result as a consequence of the ability of svD2 to cross-link cell-surface receptors.

公开(公告)号：US09155796B2

公开(公告)日：2015-10-13

申请号：US14097215

申请日：2013-12-04

申请人： SUSAVION BIOSCIENCES, INC.

发明人： Laura L. Eggink ,  J. Kenneth Hoober

IPC分类号： A61K9/00 ,  A61K38/08 ,  A61L15/32 ,  C07K1/113 ,  A61K47/48 ,  A61K38/02

CPC分类号： A61K47/48176 ,  A61K38/02 ,  A61K38/08 ,  A61K47/48784 ,  A61K47/58 ,  A61K47/6903 ,  A61L15/32 ,  C07K1/1133

摘要： The present invention provides methods of synthesizing hydrogels that contain covalently linked polypeptides. These polypeptides may be tetravalent peptides or polypeptides that bind to cell surface receptors. The hydrogels synthesized by the methods of the present invention may be used in wound dressings or applied directly to wounds to promote healing.

摘要翻译： 本发明提供合成含有共价连接多肽的水凝胶的方法。 这些多肽可以是结合细胞表面受体的四价肽或多肽。 通过本发明的方法合成的水凝胶可以用于伤口敷料中或直接施加到伤口上以促进愈合。

公开(公告)号：US20210069285A1

公开(公告)日：2021-03-11

申请号：US16960267

申请日：2019-01-03

申请人： SUSAVION BIOSCIENCES, INC.

发明人： Laura L. Eggink ,  J. Kenneth Hoober

IPC分类号： A61K38/08 ,  A61P35/00 ,  A61K31/7084 ,  A61K47/55

摘要： The present disclosure relates to pharmaceutical compositions comprising a peptide or multivalent polypeptide, and an anti-cancer agent. In some embodiments, the anti-cancer agent is conjugated to the peptide or multivalent polypeptide. The present disclosure also relates to a method of treating cancer or reducing cancer cell proliferation using the peptide or multivalent polypeptide. In some aspects, the peptide or multivalent polypeptide enhances the efficacy of the anti-cancer agent, the targeting of the anti-cancer agent to the cancer cells, or both.

公开(公告)号：US10821151B2

公开(公告)日：2020-11-03

申请号：US16512329

申请日：2019-07-15

申请人： SUSAVION BIOSCIENCES, INC.

发明人： Laura L. Eggink ,  J. Kenneth Hoober

IPC分类号： A61K38/08 ,  A61K39/395 ,  A61P37/02 ,  A61P31/12 ,  A61P35/00 ,  A61K45/00 ,  A61K45/06 ,  A61K39/00

摘要： The methods and compounds disclosed herein are useful in treating a subject having cancer or a viral infection by modulating the innate and adaptive immune systems typically by both inhibiting the function of inhibitory receptors and enhancing activity of activating receptors. Preferred therapeutic compositions comprise a carrier; at least one agent selected from the group consisting of: an anti-inflammatory agent, a cytotoxic T cell proliferation agent, or a NK cell proliferation agent; and a therapeutic peptide of the invention. In certain embodiments the compositions further include a second therapeutic peptide and/or an immunoglobulin admixed therewith in an amount sufficient to enhance passive immunoprotection in the subject.