公开(公告)号：US4720454A

公开(公告)日：1988-01-19

申请号：US601650

申请日：1984-04-18

Applicant: Perrin C. White ,  Bo Dupont ,  Maria I. New

Inventor： Perrin C. White ,  Bo Dupont ,  Maria I. New

IPC: C12N9/02 ,  C12Q1/68 ,  C12N15/00

CPC classification number: C12N9/0087 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/172

Abstract: A cDNA clone is isolated encoding a bovine adrenal cytochrome P-450 specific for steroid 21-hydroxylation (P-450.sub.C21). This plasmid pC21a contains an insert of 520 base pairs. It hybridizes with mRNA encoding P-450.sub.C21. The peptide encoded by the insert is highly homologous to two peptides isolated from porcine P-450.sub.C21 and shows limited homology to the P-450 induced by phenobarbital in rat liver. This probe and its human equivalents can be used to screen in utero i.e. pre-natal as well as post-natal patients for adrenal hyperplasia since it reacts well with human DNA as shown. These probes can also be useful for an industrial fermentation process to produce cortisone in quantity.

Abstract translation: 分离cDNA克隆，其编码对类固醇21-羟基化（P-450C21）特异性的牛肾上腺细胞色素P-450。 该质粒pC21a含有520个碱基对的插入片段。 它与编码P-450C21的mRNA杂交。 由插入片段编码的肽与从猪P-450C21分离的两种肽高度同源，并且与大鼠肝脏中苯巴比妥诱导的P-450显示有限的同源性。 该探针及其人类等同物可用于筛选子宫内，即出生前以及出生后患者的肾上腺增生，因为如图所示，它与人类DNA发生反应良好。 这些探针也可用于工业发酵过程以量产生可的松。

公开(公告)号：US12221489B2

公开(公告)日：2025-02-11

申请号：US17004331

申请日：2020-08-27

Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE ,  SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH

Inventor： Xingxing Zang ,  James P. Allison

IPC: C07K16/28 ,  A61K9/00 ,  A61K39/395 ,  A61K45/06 ,  A61K49/00 ,  C07K16/30 ,  G01N33/50 ,  A61K39/00

Abstract: Methods are provided for treating metastatic cancer in patients having metastatic cancer or for preventing metastasis in cancer patients at risk for metastasis comprising administering to the patient an antibody to B7x, or an active antibody fragment that binds B7x, in an amount effective to treat or prevent metastasis.

公开(公告)号：US20250005712A1

公开(公告)日：2025-01-02

申请号：US18707555

申请日：2022-11-04

Applicant: Memorial Sloan-Kettering Cancer Center ,  Memorial Hospital for Cancer and Allied Diseases ,  Sloan-Kettering Institute for Cancer Research

Inventor： Ross Schmidtlein ,  Yuseheng Xu ,  Andrzej Krol ,  Howard Gifford

IPC: G06T5/10 ,  A61B6/00 ,  A61B6/40 ,  A61B6/42 ,  G06T5/70 ,  G06T11/00

Abstract: Described embodiments provide systems and methods for generating a corrected planar scintigraphy image (CPSI) corrected for image artifacts. A computing system can obtain a plurality of planar scintigraphy images of a subject. The plurality of planar scintigraphy images may contain image artifacts caused by one or more physical processes. The computing system may generate a CPSI corrected for the image artifacts by applying a planar scintigraphy image reconstruction model to the plurality of planar scintigraphy images. The planar scintigraphy image reconstruction model may comprise a non-negativity constraint and be based on a regularization term and a fidelity term. The computing system may present the CPSI for evaluation of a condition of the subject. Presenting the CPSI may comprise at least one of transmitting the CPSI to a computing device or displaying the CPSI on a display screen.

公开(公告)号：US20240415888A1

公开(公告)日：2024-12-19

申请号：US18703318

申请日：2022-10-17

Applicant: Memorial Sloan Kettering Cancer Center ,  Memorial Hospital for Cancer and Allied Diseases ,  Sloan-Kettering Institute for Cancer Research

Inventor： Nai-Kong V. Cheung ,  James A. Fagin ,  Hong Fen Guo ,  Yuchen Jin ,  Jeffrey Knauf ,  Gnana Krishnamoorthy ,  Yiwei Liu ,  Brian Santich

IPC: A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K16/28 ,  C07K16/32

Abstract: The present technology provides anti-Thyroid Stimulating Hormone Receptor (TSHR) multi-specific (e.g., bispecific) immunoglobulin-related compositions and methods of using the same to treat TSHR-associated pathologies including, but not limited to, thyroid cancers, T-ALL (T lineage acute lymphoblastic leukemia), multiple myeloma and Grave's disease. Kits for use in practicing the methods are also provided.

公开(公告)号：US20240398866A1

公开(公告)日：2024-12-05

申请号：US18749775

申请日：2024-06-21

Applicant: MEMORIAL SLOAN-KETTERING CANCER CENTER ,  SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH ,  MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES

Inventor： Prasad S. ADUSUMILLI ,  Michel SADELAIN ,  Nan CHEN ,  Navin CHINTALA ,  Karlo PERICA

IPC: A61K35/17 ,  A61K39/00 ,  C07K14/47 ,  C07K14/705 ,  C12N5/078 ,  C12N15/88

Abstract: The presently disclosed subject matter provides cells comprising a Fas ligand (FasL) polypeptide and a cFLIP polypeptide. In certain embodiments, the cells further comprise an antigen-recognizing receptor (e.g., a chimeric antigen receptor (CAR) or a T cell receptor (TCR), or a TCR like fusion molecule). Also provided are uses of the cells for cell lysis of target cells expressing Fas, and for treating diseases or disorders, e.g., tumors.

公开(公告)号：US20240394408A1

公开(公告)日：2024-11-28

申请号：US18696891

申请日：2022-09-28

Applicant: Memorial Sloan-Kettering Cancer Center ,  Memorial Hospital for Cancer and Allied Diseases ,  Sloan-Kettering Institute for Cancer Research

Inventor： Ross Schmidtlein ,  Daniel Lafontaine

IPC: G06F21/62 ,  G06V10/22 ,  G06V10/25 ,  G06V10/44 ,  G06V40/16

Abstract: Described embodiments provide systems and methods for anonymizing image data. A computing system can obtain a medical image of a subject, the medical image comprising a set of slices and being associated with a set of metadata regarding the medical image and the subject. The computing system may identify, based on the set of metadata, one or more regions of interest (ROIs) of the subject in the medical image, the ROIs corresponding with a condition to be evaluated by a clinician. The computing system may select, based on the ROIs, a modification technique to apply to the medical image, wherein selecting the modification technique comprises determining an image segment that is situated outside of the identified ROIs, the image segment comprising a distinguishing feature of the subject. The computing system may generate a modified image by applying the modification technique to the medical image to render the distinguishing feature indistinguishable.

公开(公告)号：US20240350547A1

公开(公告)日：2024-10-24

申请号：US18749852

申请日：2024-06-21

Applicant: Memorial Sloan-Kettering Cancer Center ,  Sloan-Kettering Institute for Cancer Research ,  Memorial Hospital for Cancer and Allied Diseases

Inventor： Michel Sadelain ,  Karlo Perica

IPC: A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725

CPC classification number: A61K35/17 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464438 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70575

Abstract: The presently disclosed subject matter provides cells, compositions and methods for enhancing immune responses toward tumor. It relates to cells comprising: an antigen-recognizing receptor (e.g., a chimeric antigen receptor, a TCR, or a TCR like fusion molecule), a Fas ligand polypeptide (FasL), and a gene disruption of a Fas locus. The gene disruption of the Fas locus can improve the activity and/or efficiency of the cells. The presently disclosed cells, compositions, and methods can be used in allogeneic settings.

公开(公告)号：US20240336698A1

公开(公告)日：2024-10-10

申请号：US18283547

申请日：2022-03-22

Applicant: Memorial Sloan Kettering Cancer Center ,  Sloan-Kettering Institute For Cancer Research ,  Memorial Hospital For Cancer and Allied Diseases ,  Stichting VUmc

Inventor： Maria Themeli ,  Michel Sadelain ,  Maria Sjöstrand ,  Afroditi Katsarou

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07K14/705 ,  C07K14/725

CPC classification number: C07K16/2896 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464417 ,  A61K39/464426 ,  A61P35/00 ,  C07K14/7051 ,  C07K14/70521 ,  C07K16/2878 ,  A61K2239/13 ,  A61K2239/21 ,  A61K2239/28 ,  C07K2317/24 ,  C07K2317/622

Abstract: The presently disclosed subject matter provides uses of a chimeric costimulatory receptor (CCR) targeting CD38, and cells comprising a CD38 CCR and an antigen-recognizing receptor, and uses of such cells.

公开(公告)号：US20240321396A1

公开(公告)日：2024-09-26

申请号：US18575530

申请日：2022-06-29

Applicant: Memorial Sloan-Kettering Cancer Center ,  Memorial Hospital for Cancer and Allied Diseases ,  Sloan-Kettering Institute for Cancer Research

Inventor： Jonathan Chee Ming Wan ,  Luis A. Diaz,, JR.

IPC: G16B30/00 ,  C12Q1/6874 ,  C12Q1/6883 ,  C12Q1/6886 ,  G16B40/20

CPC classification number: G16B30/00 ,  C12Q1/6874 ,  C12Q1/6883 ,  C12Q1/6886 ,  G16B40/20

Abstract: The present technology relates to methods, computing devices, and systems for identifying somatic mutational signatures (e.g., cancer, aging) from whole genome sequencing (e.g., low coverage WGS) of cell-free DNA (cfDNA) obtained from subjects. Machine learning techniques may be applied to cfDNA mutational profiles, permitting accurate discrimination between cancer patients and healthy individuals or discrimination between different cancer types.

公开(公告)号：US20240282410A1

公开(公告)日：2024-08-22

申请号：US18571085

申请日：2022-06-17

Applicant: Memorial Sloan-Kettering Cancer Center ,  Memorial Hospital for Cancer and Allied Diseases ,  Sloan-Kettering Institute for Cancer Research ,  Cleveland Clinic Foundation

Inventor： Luc Morris ,  Timothy Chan ,  Diego Chowell ,  Cristina Valero ,  Nils Weinhold ,  Seong-Keun Yoo

IPC: G16B40/20 ,  G16B20/00 ,  G16H20/17 ,  G16H50/70

CPC classification number: G16B40/20 ,  G16B20/00 ,  G16H20/17 ,  G16H50/70

Abstract: The present disclosure relates generally to methods, devices, and systems for accurately predicting the efficacy of immune checkpoint blockade therapy across multiple cancer types.