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127 条记录 (耗时 0.025 秒)

    Reduction of RF electrode edge effect
    2.
    发明授权
    Reduction of RF electrode edge effect 有权

    公开(公告)号：US09895188B2

    公开(公告)日：2018-02-20

    申请号：US14478191

    申请日：2014-09-05

    申请人： Candela Corporation

    发明人： Kevin Schomacker ,  Avner Rosenberg

    IPC分类号： A61B18/14 ,  A61N1/06 ,  A61N1/32 ,  A61B18/00

    CPC分类号： A61B18/14 ,  A61B2018/00047 ,  A61B2018/00452 ,  A61N1/06 ,  A61N1/328

    摘要： A skin surface is treated with RF energy (e.g., unipolar, monopolar, bipolar or multipolar RF delivery). A first semiconductive cap disposed on a first distal end of a first electrode and, optionally, a second semiconductive cap disposed on a second distal end of a second electrode are applied to the skin surface. RF energy is delivered from the first electrode and the second electrode through the first semiconductive cap and the second semiconductive cap, respectively, through the skin surface. The first semiconductive cap and/or the second semiconductive cap have an electrical conductivity matched or substantially matched to the skin's electrical conductivity (e.g., about 0.1 to about 2 times that of the skin).

    Transdermal System for Sustained Delivery of Polypeptides
    3.
    发明申请
    Transdermal System for Sustained Delivery of Polypeptides 审中-公开
    用于持续递送多肽的透皮系统

    公开(公告)号：US20160367791A1

    公开(公告)日：2016-12-22

    申请号：US14741180

    申请日：2015-06-16

    申请人： Syneron Medical Ltd.

    发明人： Gavit Levin ,  Hagit Sacks

    IPC分类号： A61M37/00 ,  A61K9/70 ,  A61B18/14 ,  A61K38/28 ,  A61K47/36 ,  A61K38/27 ,  A61K47/42

    CPC分类号： A61M37/00 ,  A61B18/1402 ,  A61B2018/00452 ,  A61B2018/00613 ,  A61B2018/1467 ,  A61K9/0009 ,  A61K9/7084 ,  A61K38/27 ,  A61K38/28 ,  A61K47/36 ,  A61K47/42 ,  A61M2037/0007

    摘要： A transdermal system for sustained delivery of high molecular weight hydrophilic drugs, especially peptide-, polypeptide- or protein-drugs, and methods of use thereof, are provided. The system includes an apparatus that generates micro-channels in the skin of a subject in combination with a transdermal patch comprising at least one drug reservoir layer comprising a polymeric matrix and a therapeutic or immunogenic peptide, polypeptide, or protein. The system provides sustained delivery of therapeutic or immunogenic agents, thereby achieving sustained therapeutic blood concentrations of these agents.

    摘要翻译： 提供用于持续递送高分子量亲水药物，特别是肽，多肽或蛋白质药物的透皮系统及其使用方法。 该系统包括在包含至少一个包含聚合物基质和治疗性或免疫原性肽，多肽或蛋白质的药物储存层的透皮贴剂的情况下在受试者皮肤中产生微通道的装置。 该系统提供治疗性或免疫原性药物的持续递送，从而实现这些药剂的持续治疗血液浓度。

    Electrical skin rejuvenation
    5.
    发明授权
    Electrical skin rejuvenation 有权
    电皮肤复兴

    公开(公告)号：US09278230B2

    公开(公告)日：2016-03-08

    申请号：US13203436

    申请日：2010-02-22

    申请人： Galit Levin ,  Zev Sohn

    发明人： Galit Levin ,  Zev Sohn

    IPC分类号： A61N1/40 ,  A61B18/14 ,  A61B18/00 ,  A61N1/32

    CPC分类号： A61N1/40 ,  A61B18/14 ,  A61B2018/00452 ,  A61B2018/0047 ,  A61B2018/143 ,  A61N1/328

    摘要： A method is provided for reducing a wrinkle on a skin surface (42). The method includes identifying a person having a skin surface (42) with a wrinkle and in response to identifying the person, positioning at respective sites on the skin surface (42) an array (44) of electrodes (60) coupled to an energy source (46). While the electrodes (60) are at the respective sites: during a first time period, applying energy from the energy source (46) to drive the electrodes (60) to apply radio frequency (RF) current at a first voltage, capable of ablating an epidermal layer of the skin; and during a second time period, applying energy from the energy source (46) to drive the electrodes (60) to apply current at a second voltage, lower than the first voltage. Other embodiments are also described.

    摘要翻译： 提供了一种用于减少皮肤表面（42）上的皱纹的方法。 该方法包括识别具有皱纹的皮肤表面（42）的人，并且响应于识别人，在皮肤表面（42）上的相应位置定位耦合到能量源的电极阵列（44） （46）。 当电极（60）处于相应位置时：在第一时间段期间，从能量源（46）施加能量以驱动电极（60）以在能够消融的第一电压处施加射频（RF）电流 表皮层皮肤; 并且在第二时间段期间，从能量源（46）施加能量以驱动电极（60）以比第一电压低的第二电压施加电流。 还描述了其它实施例。