公开(公告)号：USD847359S1

公开(公告)日：2019-04-30

申请号：US29631894

申请日：2018-01-03

申请人： NSE Products, Inc.

设计人： Dale G. Kern ,  Richard R. Best ,  Toan Doan

公开(公告)号：USD829445S1

公开(公告)日：2018-10-02

申请号：US29593076

申请日：2017-02-06

申请人： NSE Products, Inc.

设计人： Dale G. Kern ,  Matthew James Herd ,  Charles Frazer Kilby ,  Richard R. Best ,  Prasad Weerakoon

公开(公告)号：US10046160B1

公开(公告)日：2018-08-14

申请号：US13630513

申请日：2012-09-28

申请人： Nu Skin Enterprises, Inc.

发明人： Dale G. Kern

IPC分类号： A61N1/36 ,  A61N7/00 ,  A61N1/18 ,  A61N1/32

摘要： Disclosed is a method for treating dermis and hypodermis by placing at least a first electrode at the surface of a to-be-treated skin region and contacting a second electrode at another position on the body to be treated then applying between the electrodes a current with pulse component, said current being sufficient to produce electro-osmotic pressure/velocity wavefronts corresponding to the fundamental frequency in blood vessels in the dermis and hypodermis of the skin region.

公开(公告)号：US10022741B2

公开(公告)日：2018-07-17

申请号：US14832085

申请日：2015-08-21

申请人： NSE Products, Inc.

发明人： Kevin Gregory Fuller ,  Oliver Brian Godbold ,  Rebecca Ann Wilkins ,  Henry Charles Innes ,  Carl Gordon Hewett ,  Iain Ansell

IPC分类号： B67D7/78 ,  B05B11/00 ,  A45D34/00 ,  A45D40/00 ,  A47K5/12 ,  B01F15/02 ,  B05B12/12 ,  B05B12/14 ,  B01F5/06 ,  B01F15/00

摘要： An apparatus includes a selectively actuated fluid system having a plurality of selected fluid reservoirs, for example replaceable cartridge-type fluid reservoirs. A first subset of the reservoirs can be selectively actuated to dispense an individual fluid from the selected reservoir. A second subset of the reservoirs can be simultaneously actuated to dispense two or more fluids in mixed form.

公开(公告)号：USD778066S1

公开(公告)日：2017-02-07

申请号：US29536109

申请日：2015-08-13

申请人： NSE Products, Inc.

设计人： Dale G. Kern ,  Matthew James Herd ,  Charles Frazer Kilby

公开(公告)号：US20160208330A1

公开(公告)日：2016-07-21

申请号：US15001025

申请日：2016-01-19

申请人： NSE Products, Inc.

发明人： Angela Mastaloudis ,  Steve Wood ,  Tomas Alberto Prolla ,  Jamie Louis Barger ,  Richard Weindruch ,  Joseph Chang

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6809 ,  C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/16

摘要： Markers of caloric restriction (CR) can be identified in a selected tissue by exposing an animal to CR conditions and selecting one or more genes differentially expressed in response to CR conditions in multiple subject groups. A candidate compound can be screened for likely ability to mimic the effects of CR when administered to an animal by comparing the tissue levels of expression products of the genes in animals treated with the candidate compound to those of animals subjected to CR.

公开(公告)号：US09072780B2

公开(公告)日：2015-07-07

申请号：US13115027

申请日：2011-05-24

申请人： Angela Mastaloudis ,  Steve Wood ,  Richard Weindruch ,  Tomas Alberto Prolla ,  Jamie Louis Barger ,  Mark Bartlett ,  Scott B. Ferguson ,  Joseph Chang

发明人： Angela Mastaloudis ,  Steve Wood ,  Richard Weindruch ,  Tomas Alberto Prolla ,  Jamie Louis Barger ,  Mark Bartlett ,  Scott B. Ferguson ,  Joseph Chang

IPC分类号： A61K45/06 ,  A23L1/30 ,  A61K31/221 ,  A61K36/185 ,  A61K36/258 ,  A61K36/41 ,  A61K36/79 ,  A61K36/82 ,  A61K36/87 ,  A61Q19/08 ,  A61K8/97

CPC分类号： A61K36/062 ,  A23L33/105 ,  A23V2002/00 ,  A61K8/97 ,  A61K31/221 ,  A61K36/185 ,  A61K36/258 ,  A61K36/41 ,  A61K36/79 ,  A61K36/82 ,  A61K36/87 ,  A61K45/06 ,  A61K2800/5922 ,  A61K2800/92 ,  A61Q19/06 ,  A61Q19/08 ,  A61K2300/00 ,  A23V2200/302 ,  A23V2250/208 ,  A23V2250/21 ,  A23V2250/2124

摘要： An oral formulation as described herein can comprise pomegranate extract, panax ginseng extract, and c. sinensis, where each is present in an amount effective to counteract and/or prevent effects of aging in a subject when administered to the subject. The effects of aging can include age-related changes in gene expression.

摘要翻译： 本文所述的口服制剂可以包含石榴提取物，人参提取物，和c。 中华每个在施用于受试者时以有效抵消和/或预防受试者的老化作用的量存在。 老化的影响可能包括年龄相关的基因表达变化。

公开(公告)号：USD933840S1

公开(公告)日：2021-10-19

申请号：US29732120

申请日：2020-04-21

申请人： NSE PRODUCTS, INC.

设计人： Matthew Hermann ,  Thierry Sorhaïtz ,  DucToan T. Doan ,  Mukul Bokil

公开(公告)号：US20190008332A1

公开(公告)日：2019-01-10

申请号：US15752422

申请日：2016-08-12

申请人： NSE PRODUCTS, INC.

发明人： Samuel Luke Johnstone ,  Matthew James Herd ,  Charles Frazer Kilby

IPC分类号： A47K7/04 ,  A46D1/00 ,  A46B5/00 ,  A46B13/00 ,  A46B13/02

摘要： A cleansing device for mammalian skin includes a cleansing head having a plurality of elastomeric cleansing features extending away from a first surface of the cleansing head. The cleansing head is attached to a handle. The cleansing device includes an actuator coupled to a rotating drive shaft and adapted to apply oscillating movement to one or more cleansing head sections of the cleansing head at a frequency of about 5 Hz to 30 Hz.

公开(公告)号：US10131946B1

公开(公告)日：2018-11-20

申请号：US14704880

申请日：2015-05-05

申请人： NSE Products, Inc.

发明人： Dale Kern ,  Jin Namkoong

IPC分类号： C12Q1/68 ,  C12Q1/6876

摘要： A method is provided for characterizing a lipofilling agent causing increased lipofilling activity in adipose tissue from a target body area. Such a method can include obtaining a plurality of distinct preadipocyte cultures taken from a plurality of distinct body areas of an individual, exposing the plurality of distinct preadipocyte cultures to a plurality of potential lipofilling agents, culturing the plurality of distinct preadipocyte cultures through differentiation to form a plurality of distinct adipocyte cultures, measuring a degree of lipofilling activity of adipocytes from each of the plurality of distinct adipocyte cultures, and quantifying the measured lipofilling activity across the plurality of distinct adipocyte cultures to identify a lipofilling agent causing increased lipofilling activity in adipose tissue from the target body area as compared to adipose tissue in the non-target body area.