公开(公告)号：US20240307548A1

公开(公告)日：2024-09-19

申请号：US18279938

申请日：2022-03-04

Applicant: Code Biotherapeutics, Inc. ,  University of Maryland, College Park

Inventor： Silvia Muro ,  Niksa Roki ,  Robert Getts

IPC: A61K47/68 ,  A61K9/00 ,  A61K39/00 ,  A61K47/42 ,  C07K16/28 ,  C07K19/00

CPC classification number: A61K47/6807 ,  A61K9/0019 ,  A61K47/42 ,  A61K47/6849 ,  C07K16/2821 ,  C07K19/00 ,  A61K2039/505 ,  C07K2317/40 ,  C07K2317/92 ,  C07K2317/94 ,  C12N2310/3513

Abstract: The present disclosure provides antibodies, and fragments thereof, conjugated to an oligonucleotide, wherein the oligonucleotide is not hybridized to a DNA dendrimer, compositions comprising the same, and uses thereof in methods of detection, methods of cell isolation, methods of depletion, methods of diagnosis, and methods of treatment.

公开(公告)号：US20230136794A1

公开(公告)日：2023-05-04

申请号：US17836304

申请日：2022-06-09

Applicant: Code Biotherapeutics, Inc.

Inventor： Robert C. Getts ,  James M. Kadushin ,  Lori Getts

IPC: A61K47/68 ,  A61K47/56 ,  C12N15/11

Abstract: The present disclosure provides nucleic acid carriers comprising targeting agents, pharmaceutical compositions comprising the same, and methods of making and using the same.

公开(公告)号：US20220143197A1

公开(公告)日：2022-05-12

申请号：US17304402

申请日：2021-06-21

Applicant: CODE BIOTHERAPEUTICS, INC. ,  Lankenau Institute of Medical Research

Inventor： Robert C. Getts ,  Janet Sawicki

IPC: A61K47/55 ,  C12N15/113 ,  A61K31/713 ,  A61K47/59 ,  A61K47/68 ,  A61K47/54 ,  A61K47/64 ,  A61P35/00 ,  A61K9/00

Abstract: DNA dendrimers linked to both a targeting moiety and a siRNA which inhibits expression of Human antigen R (HuR), pharmaceutical compositions comprising the DNA dendrimers and methods of treatment and use employing the DNA dendrimers. Useful siRNA sequences are also disclosed.

公开(公告)号：US12195531B2

公开(公告)日：2025-01-14

申请号：US16568702

申请日：2019-09-12

Applicant: CODE BIOTHERAPEUTICS, INC. ,  Lankenau Institute of Medical Research

Inventor： Robert C. Getts ,  James Kadushin ,  Mindy George-Weinstein ,  Jacquelyn Gerhart ,  Emanuela Dylgjeri ,  Kelly Rhodes

IPC: C07K16/28 ,  A61K9/51 ,  A61K31/704 ,  A61K31/713 ,  A61K47/54 ,  A61K47/62 ,  A61K47/68 ,  A61K47/69

Abstract: Compositions and methods for targeted delivery of active agents to cells are provided. The compositions comprise a wholly or partially double-stranded synthetic DNA carrier, and an active agent intercalated in double-stranded portions of the DNA carrier. The DNA carrier may also be linked to a targeting agent. The compositions are useful for delivering an active agent into a targeted cell type, for example a cytotoxic agent.

公开(公告)号：US12076410B2

公开(公告)日：2024-09-03

申请号：US15999781

申请日：2017-02-17

Applicant: Code Biotherapeutics, Inc.

Inventor： Robert C. Getts ,  James M. Kadushin ,  Lori Getts

IPC: A61K47/68 ,  A61K8/60 ,  A61K39/44 ,  A61K47/54 ,  A61K47/56

CPC classification number: A61K47/6881 ,  A61K8/606 ,  A61K39/44 ,  A61K47/549 ,  A61K47/56 ,  A61K47/6807 ,  A61K47/6811 ,  A61K47/6849 ,  A61K47/6889

Abstract: The present disclosure provides nucleic acid carriers comprising one or more layers comprising multiple monomers, wherein each monomer comprises: a first and a second oligonucleotide; wherein a central portion of each of the first and second oligonucleotides is complementary to each other, forming a double-stranded region, wherein the two terminal portions of the first oligonucleotide are not complementary to the two terminal portions of the second oligonucleotide, forming four terminal arms; and at least one targeting agent conjugated to at least one peripheral terminal arm, wherein when the at least one targeting agent is an miRNA. The present disclosure also provides pharmaceutical composition comprising any of the nucleic acid carriers described herein, and a pharmaceutically acceptable vehicle. The present disclosure also provides methods of inducing an immune response in an animal comprising administering to the animal any of the nucleic acid carriers described herein.

公开(公告)号：US20230338557A1

公开(公告)日：2023-10-26

申请号：US18166688

申请日：2023-02-09

Applicant: Code Biotherapeutics, Inc.

Inventor： Robert C. Getts ,  Jennifer Luke

IPC: A61K47/64 ,  C08G83/00

CPC classification number: A61K47/6455 ,  C08G83/003

Abstract: The embodiments provide compositions comprising DNA dendrimers, targeting molecules, therapeutic agents, adaptor molecules, support molecules, or combinations thereof. Pharmaceutical compositions, kits, and methods using and producing the same are also provided.

公开(公告)号：US20250049942A1

公开(公告)日：2025-02-13

申请号：US18782174

申请日：2024-07-24

Applicant: Code Biotherapeutics, Inc.

Inventor： Robert C. Getts ,  James M. Kadushin ,  Lori Getts

IPC: A61K47/68 ,  A61K8/60 ,  A61K39/44 ,  A61K47/54 ,  A61K47/56

Abstract: The present disclosure provides nucleic acid carriers comprising targeting agents, pharmaceutical compositions comprising the same, and methods of making and using the same.

公开(公告)号：US11802151B2

公开(公告)日：2023-10-31

申请号：US17088256

申请日：2020-11-03

Applicant: Code Biotherapeutics, Inc.

Inventor： Robert Getts ,  Jessica Bowers ,  Mindy Ellen George-Weinstein ,  Jacquelyn Gerhart

IPC: C07K16/28 ,  G01N33/53 ,  C07K16/18 ,  A61K47/68 ,  G01N33/68 ,  A61K31/713 ,  G01N33/574 ,  A61K39/00

CPC classification number: C07K16/28 ,  A61K31/713 ,  A61K47/6803 ,  A61K47/6843 ,  C07K16/18 ,  G01N33/574 ,  G01N33/68 ,  A61K39/001102 ,  C07K2317/24

Abstract: The present disclosure provides an antibody that binds human Adhesion G Protein-Coupled Receptor B1 (BAI1) protein, compositions comprising the same, and use thereof in methods of detection, methods of diagnosis, and methods of treatment.