-
公开(公告)号：US11667705B2
公开(公告)日：2023-06-06
申请号：US16843474
申请日：2020-04-08
发明人： Bryan Edwards , Ulla Lashmar , Brian McGuinness , Mike Romanos , Thomas Sandal , Yumin Teng
IPC分类号： C07K16/24 , A61K39/395 , A01K67/027 , C12N15/63 , A61P37/02 , A61P31/00 , A61P37/06 , A61P37/08 , G01N33/68 , A61K39/00
CPC分类号： C07K16/244 , A01K67/0278 , A61K39/3955 , A61P31/00 , A61P37/02 , A61P37/06 , A61P37/08 , C12N15/63 , G01N33/6869 , A01K2217/072 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/01 , A61K2039/505 , C07K2317/565 , C07K2317/569 , C07K2317/92 , G01N2333/54
摘要： Binding molecules to IL-17A. The binding molecules are useful in the treatment of disorders, for example psoriasis.
-
公开(公告)号：US20220306744A1
公开(公告)日：2022-09-29
申请号：US17706839
申请日：2022-03-29
发明人： Carolyn EDWARDS , James LEGG , Martyna LEWANDOWSKA , Colette JOHNSTON , Christine ROSSANT , Yumin TENG
IPC分类号： C07K16/28 , C12N15/85 , G01N33/68 , A61P35/00 , A01K67/027
摘要： The invention relates to multifunctional PD-1 binding agents and the use of such binding agents in the treatment, prevention and detection of disease.
-
公开(公告)号：US20220112305A1
公开(公告)日：2022-04-14
申请号：US17508583
申请日：2021-10-22
发明人： Brian McGuinness , Isabelle Osuch , Chris Rossant , Mike Romanos , Nikki Royle , Thomas Sandal , Lorraine Thompson , Michele Writer
摘要： The invention relates to binding molecules that bind specifically to prostate specific membrane antigen (PSMA), in particular, single human variable heavy chain domain antibodies and related methods for treatment of cancer.
-
公开(公告)号：US10400030B2
公开(公告)日：2019-09-03
申请号：US15540400
申请日：2016-01-12
发明人： Bryan Edwards , Yumin Teng
摘要： The invention relates to a method of designing an immunoglobulin library for optimization of a biological property of a first lead immunoglobulin and libraries of optimized immunoglobulins produced by such methods.
-
公开(公告)号：US20180002403A1
公开(公告)日：2018-01-04
申请号：US15540400
申请日：2016-01-12
发明人： Bryan EDWARDS , Yumin TENG
CPC分类号： C07K16/005 , C07K16/00 , C07K16/244 , C07K16/2866 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/92 , C12N15/1037 , C12N15/1082 , C40B50/06
摘要： The invention relates to a method of designing an immunoglobulin library for optimisation of a biological property of a first lead immunoglobulin and libraries of optimised immunoglobulins produced by such methods.
-
公开(公告)号：US20170049083A1
公开(公告)日：2017-02-23
申请号：US15230564
申请日：2016-08-08
发明人： Marianne Brüggemann , Xiangang Zou
IPC分类号： A01K67/027 , C07K16/06
CPC分类号： A01K67/0276 , A01K2217/058 , A01K2217/075 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/06 , C07K2317/56 , C12N2800/30
摘要： The present invention provides in a first aspect a mouse in which the λ (lambda) light chain locus has been functionally silenced. In one embodiment, the mouse λ light chain locus was functional silenced by deletion of gene segments coding for the λ light chain locus. In a further aspect, a mouse containing functionally silenced λ and κ (kappa) L chain loci was produced. The invention is useful for the production of antibodies, for example heterologous antibodies, including heavy chain only antibodies.
摘要翻译： 本发明在第一方面提供了一种其中λ（λ）轻链基因座功能性沉默的小鼠。 在一个实施方案中，小鼠λ轻链基因座通过缺失编码λ轻链基因座的基因片段而被功能性沉默。 另一方面，产生含有功能性沉默的λ和κ（κ）L链基因座的小鼠。 本发明可用于生产抗体，例如异源抗体，包括仅重链抗体。
-
公开(公告)号：US09439405B2
公开(公告)日：2016-09-13
申请号：US13654007
申请日：2012-10-17
发明人： Marianne Brüggemann , Xiangang Zou
IPC分类号： A01K67/00 , A01K67/027 , C07K16/00
CPC分类号： A01K67/0276 , A01K2217/058 , A01K2217/075 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/06 , C07K2317/56 , C12N2800/30
摘要： The present invention provides in a first aspect a mouse in which the λ (lambda) light chain locus has been functionally silenced. In one embodiment, the mouse λ light chain locus was functional silenced by deletion of acne segments coding for the λ light chain locus. In a further aspect, a mouse containing functionally silenced λ and κ (kappa) L chain loci was produced. The invention is useful for the production of antibodies, for example heterologous antibodies, including heavy chain only antibodies.
摘要翻译： 本发明在第一方面提供了一种其中λ（λ）轻链基因座功能性沉默的小鼠。 在一个实施方案中，小鼠λ轻链基因座通过缺失编码λ轻链基因座的痤疮节段而被功能性沉默。 另一方面，产生含有功能性沉默的λ和κ（κ）L链基因座的小鼠。 本发明可用于生产抗体，例如异源抗体，包括仅重链抗体。
-
公开(公告)号：US12077595B2
公开(公告)日：2024-09-03
申请号：US16763059
申请日：2018-11-13
发明人： Verena Brucklacher-Waldert , Carolyn Edwards , James Legg , Jayesh Majithiya , Brian McGuinness , Christine Rossant , Yumin Teng
CPC分类号： C07K16/2878 , C07K16/2896 , C07K16/30 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/75 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： The disclosure relates to CD137 binding agents and the use of such binding agents in the treatment, prevention and detection of disease.
-
公开(公告)号：US11951172B2
公开(公告)日：2024-04-09
申请号：US16969905
申请日：2019-02-18
发明人： Carolyn Edwards , Angelica Sette , Isabelle Osuch , Yumin Teng , James Legg , David Escors Murugarren
CPC分类号： A61K47/6801 , A61K39/3955 , C07K16/2818 , C12N15/10 , C07K16/28 , C07K16/2803 , C07K16/46 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/626 , C07K2317/94 , C07K2319/00
摘要： The invention relates to LAG-3 binding agents, in particular variable heavy chain (VH) sdAbs and bispecific agents that target both LAG-3 and PD-1, and the use of such binding agents in the treatment, prevention and detection of disease.
-
公开(公告)号：US11866510B2
公开(公告)日：2024-01-09
申请号：US16099099
申请日：2017-05-08
发明人： Brian McGuinness , Colette Johnston
IPC分类号： C07K14/705 , C12N5/0783 , A61K35/17 , A61P35/00 , A61K39/00 , C07K16/30 , C07K16/00
CPC分类号： C07K16/3069 , A61K35/17 , A61K39/0011 , A61P35/00 , C07K16/00 , C12N5/0646 , A61K2039/5158 , C07K2317/569 , C07K2319/03
摘要： The invention relates to chimeric antigen receptors (CAR) that comprise one or more single human variable domain antibody and cells that express such CAR. In particular, the invention relates to CARs that include multiple single human variable domain antibodies. In a particular embodiment, the one or more single human variable domain antibody binds to prostate membrane antigen.
-
-
-
-
-
-
-
-
-
搜索结果
38 条记录 (耗时 0.021 秒)
