公开(公告)号：US20240361248A1

公开(公告)日：2024-10-31

申请号：US18661672

申请日：2024-05-12

申请人： Beckman Coulter, Inc.

发明人： Takayuki MIZUTANI ,  Amit SAWHNEY ,  Kevin Louis NOWAK ,  Laura Elizabeth Schilling HOLMES ,  Jessica Melissa Mattke TUBMAN

IPC分类号： G01N21/65 ,  G01N35/00 ,  G01N35/10

CPC分类号： G01N21/658 ,  G01N35/00693 ,  G01N35/0092 ,  G01N35/1002 ,  G01N2035/00346 ,  G01N2201/06113

摘要： The presently claimed and described technology provides systems and methods for determining concentration of an analyte of interest using Surface Enhanced Raman Spectroscopy (SERS). An automated SERS system can include a body for accepting a substrate, a fluid handling system, a light source, and a detector that collects and detects Raman scattered light.

公开(公告)号：US20240357232A1

公开(公告)日：2024-10-24

申请号：US18740301

申请日：2024-06-11

申请人： Beckman Coulter, Inc.

发明人： Jiuliu LU ,  Bian QIAN ,  John S. RILEY ,  Bart WANDERS ,  Ken GOOD

IPC分类号： H04N23/67 ,  G01N15/01 ,  G01N15/1434 ,  G06T3/40 ,  G06T7/00

CPC分类号： H04N23/67 ,  G01N15/01 ,  G01N15/1436 ,  G06T3/40 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/10148 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30024

摘要： A focusing distance (e.g., a distance between a focal plane of a camera used when n image was captured and the actual focal plane for an in-focus image) in a visual analysis system may be determined by subjecting one or more images captured by such a system to a multi-layer analysis. In such an analysis, an input may be subjected to one or more convolution filters, and the ultimate result of such convolution may be provided to a dense layer which can provide the focusing distance. This focusing distance may then be used to (re)focus a camera or for other purposes (e.g., generating an alert).

公开(公告)号：US12106588B2

公开(公告)日：2024-10-01

申请号：US18594423

申请日：2024-03-04

申请人： Beckman Coulter, Inc.

发明人： Takayuki Mizutani ,  Katsuhiro Seo ,  Shigeru Fujii ,  Kazuki Umebara ,  MArie Willette ,  Leila Nazemi

IPC分类号： G06V20/69 ,  C12M1/34 ,  G06T7/62 ,  G06V10/50 ,  G06V20/50

CPC分类号： G06V20/69 ,  C12M41/46 ,  G06T7/62 ,  G06V10/50 ,  G06V20/50 ,  G06T2207/10024 ,  G06T2207/30072

摘要： Automatic substance preparation and evaluation systems and methods are provided for preparing and evaluating a fluidic substance, such as e.g. a sample with bodily fluid, in a container and/or in a dispense tip. The systems and methods can detect volumes, evaluate integrities, and check particle concentrations in the container and/or the dispense tip.

公开(公告)号：US20240301131A1

公开(公告)日：2024-09-12

申请号：US18663716

申请日：2024-05-14

申请人： Beckman Coulter, Inc.

发明人： Arunkumar Easwaran ,  Sergei Gulnik ,  Massimiliano Tomasulo

IPC分类号： C08G61/10 ,  C09B69/10 ,  G01N33/533 ,  G01N33/542 ,  G01N33/545 ,  G01N33/58

CPC分类号： C08G61/10 ,  C09B69/105 ,  G01N33/533 ,  G01N33/542 ,  G01N33/545 ,  G01N33/582 ,  C08G2261/11 ,  C08G2261/1424 ,  C08G2261/1432 ,  C08G2261/145 ,  C08G2261/1644 ,  C08G2261/18 ,  C08G2261/228 ,  C08G2261/314 ,  C08G2261/78 ,  C08G2261/94

摘要： Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.

公开(公告)号：US20240296959A1

公开(公告)日：2024-09-05

申请号：US18661180

申请日：2024-05-10

申请人： Beckman Coulter, Inc.

发明人： Sean M. ROBERTS ,  Girish Simon

IPC分类号： G16H50/30 ,  G16H10/60

CPC分类号： G16H50/30 ,  G16H10/60

摘要： A computer-implemented method of determining a major adverse cardiovascular event, risk of MACE, in a patient, is provided. The method comprises receiving, with a computing device, subject value data for the patient, the subject value data including (i) at least one troponin value, (ii) at least one demographic value, and (iii) at least one of a value for prior history of cardiac disease, a value of prior history of renal disease, an erythrocyte mean corpuscular hemoglobin value and an electrolyte value. Further, the method comprises evaluating, with the computing device, the received subject value data of the patient based on a reference dataset indicative of reference subject values associated with one or more reference patients, wherein the reference dataset is indicative of reference subject values including (i) at least one troponin value, (ii) at least one demographic value, and (iii) a value for prior history of cardiac disease. Further, the risk of MACE is determined based on the evaluation.

公开(公告)号：US20240272189A1

公开(公告)日：2024-08-15

申请号：US18647869

申请日：2024-04-26

申请人： Beckman Coulter, Inc.

发明人： Noriyuki ITO ,  Noriyoshi OKADA ,  Takayuki MIZUTANI

IPC分类号： G01N35/10

CPC分类号： G01N35/1002

摘要： A system (100) is provided for an automated analyzer (10) having an analyzer arrangement (20) configured to consume liquid consumables (30L) when in an active mode (12). The liquid consumables (30L) are delivered to the automated analyzer (10) via consumables containers (30). The system (100) comprises a storage magazine (120) configured to removably hold at least one of the consumables containers (30), a tray (150) configured to manually receive one or more of the consumables containers (30) from an operator at least while the analyzer arrangement (20) is in the active mode (12), and a transfer system (250) configured to transfer one or more of the consumables containers (30) at least between the tray (150) and the storage magazine (120). The transfer system (250) transfers one or more of the consumables containers (30) to or from the storage magazine (120) at least while the tray (150) manually receives one or more of the consumables containers (30) from the operator.

公开(公告)号：US11994514B2

公开(公告)日：2024-05-28

申请号：US16390597

申请日：2019-04-22

申请人： Beckman Coulter, Inc.

发明人： Diana B. Careaga ,  Robert T. Magari ,  Liliana M. Tejidor ,  Nicole Carpio

IPC分类号： G01N33/50 ,  A61B5/00 ,  G01N15/01 ,  G01N15/1031 ,  G01N15/14 ,  G01N33/487 ,  G01N33/49 ,  G01N33/569 ,  G16H10/40 ,  G01N15/06

CPC分类号： G01N33/5094 ,  A61B5/412 ,  G01N15/1031 ,  G01N33/48735 ,  G01N33/49 ,  G01N33/5091 ,  G01N33/56972 ,  G16H10/40 ,  G01N2015/016 ,  G01N15/0656 ,  G01N2015/1402 ,  G01N2800/26

摘要： Embodiments of the present disclosure may allow for an efficient and accurate way or system to assess whether an individual has sepsis, including an individual who may exhibit symptoms or clinical criteria similar to inflammation. Embodiments include using a laboratory test that may be routinely ordered. Embodiments of the present invention may allow for the diagnosis of sepsis even when some cells show an abnormal size. Often, when white blood cells show a likelihood of an abnormal size, a “blast flag” in a system is triggered to warn a user that the sample may warrant further analysis. Unexpectedly, the diagnosis of sepsis status using standard deviation of monocyte volume may be more accurate when considering whether a blast flag has been triggered. Based on the sepsis status, treatment may be started quickly, thereby preventing complications, including organ failure and death, of not treating sepsis fast enough.

公开(公告)号：US11977088B2

公开(公告)日：2024-05-07

申请号：US16313704

申请日：2017-06-16

申请人： Beckman Coulter, Inc.

发明人： Wido Menhardt ,  Matthew Hanson ,  Anthony Camisa

IPC分类号： G01N35/00 ,  B01L9/06 ,  G16H10/40

CPC分类号： G01N35/00613 ,  B01L9/06 ,  G01N35/00712 ,  G01N35/00871 ,  G16H10/40 ,  B01L2200/14 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2200/185 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/0663 ,  G01N2035/00752 ,  G01N2035/00851

摘要： A method of reducing quality problems associated with patient sample collection and delivery is provided. It is possible that the method can provide a chain of custody process to better track a sample from the initial point of sample collection to the final point of sample testing. Such a method can also include providing an alert to indicate a potential problem with the quality of the diagnostic test result when a measured parameter exceeds a threshold.

公开(公告)号：US11955230B2

公开(公告)日：2024-04-09

申请号：US17539440

申请日：2021-12-01

申请人： Beckman Coulter, Inc.

发明人： Martha C. Davis

IPC分类号： G16H40/40 ,  G06F8/65 ,  G06F16/2457 ,  G16H10/40 ,  G16H40/67 ,  G06F21/62 ,  H04L9/40

CPC分类号： G16H40/40 ,  G06F8/65 ,  G06F16/24578 ,  G16H10/40 ,  G16H40/67 ,  G06F21/6245 ,  H04L63/029 ,  H04L63/0428

摘要： Described herein are database systems including one or more remote analytical instruments operably connected to one or more servers. The instruments can transmit rich data to the servers, and the one or more servers can compile a database of the rich data. One or more processors associated with the servers can be configured to execute a data analytics program on the database to identify a stochastic phenomenon or to process the data and present in real-time at a location of the one or more instruments comparison information about the instruments.

公开(公告)号：US11954925B2

公开(公告)日：2024-04-09

申请号：US17682809

申请日：2022-02-28

申请人： Beckman Coulter, Inc.

发明人： Takayuki Mizutani ,  Katsuhiro Seo ,  Shigeru Fujii ,  Kazuki Umebara

IPC分类号： G06V20/69 ,  C12M1/34 ,  G06T7/62 ,  G06V10/50 ,  G06V20/50

CPC分类号： G06V20/69 ,  C12M41/46 ,  G06T7/62 ,  G06V10/50 ,  G06V20/50 ,  G06T2207/10024 ,  G06T2207/30072

摘要： Automatic substance preparation and evaluation systems and methods are provided for preparing and evaluating a fluidic substance, such as e.g. a sample with bodily fluid, in a container and/or in a dispense tip. The systems and methods can detect volumes, evaluate integrities, and check particle concentrations in the container and/or the dispense tip.