公开(公告)号：US20150344513A9

公开(公告)日：2015-12-03

申请号：US14406074

申请日：2013-06-03

Applicant: Academia Sinica

Inventor： Shang-Cheng Hung ,  Cheng-Hsiu Chang

IPC: C07H15/04 ,  C07H1/00 ,  C07H23/00

CPC classification number: C07H15/04 ,  C07H1/00 ,  C07H3/06 ,  C07H15/18 ,  C07H15/203 ,  C07H23/00

Abstract: The present invention relates to methods for the synthesis of fondaparinux and intermediates thereto.

Abstract translation: 本发明涉及磺达肝素合成方法及其中间体。

公开(公告)号：US09193750B2

公开(公告)日：2015-11-24

申请号：US14288418

申请日：2014-05-28

Applicant: Dow AgroSciences LLC

Inventor： Lawrence C. Creemer ,  Carl DeAmicis ,  Gary D. Crouse ,  Peter Borromeo

IPC: C07H1/00 ,  C07H13/12 ,  C07H15/04

CPC classification number: C07H13/12 ,  C07H1/00 ,  C07H15/04

Abstract: Triaryl rhamnose carbamate insecticides are prepared from triaryl acyl azides and tetrahydropyran-2-ols in good yield without the use of a hydride base.

Abstract translation: 三芳基鼠李糖氨基甲酸酯杀虫剂由三芳基酰基叠氮化物和四氢吡喃-2-醇以良好的产率制备而不使用氢化物​​碱。

公开(公告)号：US09181292B2

公开(公告)日：2015-11-10

申请号：US13344557

申请日：2012-01-05

Applicant: Pi-Hui Liang

Inventor： Pi-Hui Liang

IPC: C07H15/18 ,  C07H1/00 ,  C07H15/06 ,  A61K39/39 ,  C07H15/04

CPC classification number: C07H1/00 ,  A61K39/39 ,  C07B2200/07 ,  C07H15/04 ,  C07H15/06 ,  C07H15/18 ,  Y02P20/55 ,  A61K31/7028 ,  A61K31/715

Abstract: Methods for synthesis and preparation of alpha-glycosphingolipids are provided. Methods for synthesis of α-galactosyl ceramide, and pharmaceutically active analogs and variants thereof are provided. Novel alpha-glycosphingolipids are provided, wherein the compounds are immunogenic compounds which serve as ligands for NKT (natural killer T) cells.

Abstract translation: 提供了α-糖苷脂的合成和制备方法。 提供了α-半乳糖神经酰胺的合成方法及其药物活性类似物及其变体。 提供了新的α-糖苷脂，其中所述化合物是用作NKT（天然杀伤T）细胞配体的免疫原性化合物。

公开(公告)号：US20150291644A1

公开(公告)日：2015-10-15

申请号：US14646808

申请日：2013-11-28

Applicant: VICTORIA LINK LIMITED ,  UNIVERSITY OF LIVERPOOL

Inventor： Peter Charles Tyler ,  Olga Vladimirovna Zubkova ,  Jeremy E. Turnbull

IPC: C07H15/08 ,  C07H15/04

CPC classification number: C07H15/08 ,  C07H15/04

Abstract: The invention relates to dendritic compounds, the use of these compounds as pharmaceuticals, pharmaceutical compositions containing the compounds, processes for preparing the compounds, and methods of treating diseases or conditions in which it is desirable to inhibit β-secretase.

Abstract translation: 本发明涉及树枝状化合物，这些化合物作为药物的用途，含有这些化合物的药物组合物，制备该化合物的方法，以及治疗期望抑制和分泌酶的疾病或病症的方法。

公开(公告)号：US20150252068A1

公开(公告)日：2015-09-10

申请号：US14435222

申请日：2013-10-11

Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

Inventor： Dennis L. Kasper ,  Dingding An ,  Sungwhan Oh ,  Richard S. Blumberg ,  Torsten Olszak ,  Joana Pereira Das Neves

IPC: C07H15/04 ,  C12N5/0783 ,  A61K38/17 ,  A61K35/17 ,  A61K31/7028 ,  A61K45/06

CPC classification number: C07H15/04 ,  A61K31/70 ,  A61K31/7028 ,  A61K35/17 ,  A61K38/177 ,  A61K45/06 ,  C12N5/0646 ,  C12N2502/11

Abstract: The invention provides, inter alia, immunoinhibitory glycosphingolipids and immunoinhibitory alpha-galactosylceamides and compositions and preparations thereof, and methods of use thereof including in the treatment of conditions characterized by increased iNKT cells and/or activity.

Abstract translation: 本发明尤其提供了免疫抑制性糖鞘脂和免疫抑制性α-半乳糖苷酰胺及其组合物和制剂及其使用方法，其包括用于治疗以增强的iNKT细胞和/或活性为特征的病症。

公开(公告)号：US09086416B2

公开(公告)日：2015-07-21

申请号：US13548181

申请日：2012-07-12

Applicant: Wen-Bin Yang

Inventor： Wen-Bin Yang

IPC: A61K31/70 ,  A61K31/7028 ,  A61K31/7042 ,  C07H15/00 ,  C07H15/04 ,  C07H17/00 ,  G01N33/58 ,  C07H15/26 ,  G01N33/531

CPC classification number: G01N33/58 ,  C07H15/26 ,  G01N33/531 ,  Y10T436/14

Abstract: Novel method and reagents for generating reversibly tagged saccharides, aldehydes, carboxyl acids, or orthoacetates useful in analytical and diagnostic applications are disclosed. Saccharides are coupled at the reducing end to tagging moieties comprising a reagent selected from a ortho-diaminobenzoic (DAB)-peptide, an aldo-imidazole or N-methylated aldo-imidazole, or an ortho-phenyldiamine (OPD) or substituted OPD. The tagged saccharide further comprising detectable or functional groups coupled to the tagging moiety are provided. Kits and reagents for chromatography and mass spectrometry are disclosed.

Abstract translation: 公开了用于生成可用于分析和诊断应用的可逆标记的糖，醛，羧酸或原乙酸盐的新方法和试剂。 糖在还原端耦合到包含选自邻二氨基苯甲酸（DAB）肽，醛 - 咪唑或N-甲基化的醛 - 咪唑或邻苯基二胺（OPD）或取代的OPD的试剂的标记部分。 提供了进一步包含与标记部分偶联的可检测或官能团的标记糖。 公开了用于色谱和质谱的试剂盒和试剂。

公开(公告)号：US20150025157A1

公开(公告)日：2015-01-22

申请号：US14383654

申请日：2013-03-08

Applicant: KYUSHU UNIVERSITY ,  INSTITUTE OF SYSTEMS, INFORMATION TECHNOLOGIES AND NANOTECHNOLOGIES ,  NISSAN CHEMICAL INDUSTRIES, LTD.

Inventor： Fumiyasu Ono ,  Seiji Shinkai ,  Osamu Hirata

IPC: C07H15/04 ,  H01M10/0565 ,  A61K8/04 ,  H01B1/12 ,  A61K47/26 ,  A61K8/60 ,  A23L1/05 ,  H01M10/052

CPC classification number: C07H15/04 ,  A23L29/20 ,  A23V2002/00 ,  A61K8/042 ,  A61K8/60 ,  A61K47/26 ,  A61K2800/10 ,  A61K2800/48 ,  A61Q19/00 ,  C07H9/04 ,  C09K3/00 ,  H01B1/12 ,  H01M10/052 ,  H01M10/0565 ,  H01M2300/0085

Abstract: There is provided a novel gelator containing a sugar derivative. A gelator including a compound of Formula (1) or Formula (2): wherein each of R1 and R3 is independently a linear or branched alkyl group having a carbon atom number of 1 to 20, a cyclic C3-20 alkyl group, or a linear or branched alkenyl group having a carbon atom number of 2 to 20, n is 0 or an integer of 1 to 4, R2 is a hydrogen atom, a linear or branched alkyl group having a carbon atom number of 1 to 10, or an aryl group optionally having a substituent, and R4 and R5 are each a hydroxy group.

Abstract translation: 提供了含有糖衍生物的新型凝胶剂。 包括式（1）或式（2）的化合物的凝胶剂：其中R 1和R 3各自独立地为碳原子数为1至20的直链或支链烷基，环状C 3-20烷基或 碳原子数为2〜20的直链或支链烯基，n为0或1〜4的整数，R2为氢原子，碳原子数为1〜10的直链或支链烷基，或 任选具有取代基的芳基，R4和R5各自为羟基。

公开(公告)号：US08927698B2

公开(公告)日：2015-01-06

申请号：US13263716

申请日：2010-04-07

Applicant: Gyula Dékany ,  Istvan Bajza ,  Julien Boutet ,  Ignacio Pérez Figueroa ,  Markus Hederos ,  Ferenc Horvath ,  Piroska Kovács-Pénzes ,  Lars Kröger ,  Johan Olsson ,  Christoph Röhrig ,  Andreas Schroven ,  Ioannis Vrasidas

Inventor： Gyula Dékany ,  Istvan Bajza ,  Julien Boutet ,  Ignacio Pérez Figueroa ,  Markus Hederos ,  Ferenc Horvath ,  Piroska Kovács-Pénzes ,  Lars Kröger ,  Johan Olsson ,  Christoph Röhrig ,  Andreas Schroven ,  Ioannis Vrasidas

IPC: C07H3/06 ,  C07H15/203 ,  C07H15/26 ,  C07H1/00 ,  C07H15/04

CPC classification number: C07H3/06 ,  C07H1/00 ,  C07H15/04 ,  C07H15/203

Abstract: The present invention relates to an improved synthesis of a trisaccharide of the formula, novel intermediates used in the synthesis and the preparation of the intermediates.

Abstract translation: 本发明涉及下式的三糖的改进合成：用于合成和制备中间体的新型中间体。

公开(公告)号：US08916164B2

公开(公告)日：2014-12-23

申请号：US12675595

申请日：2008-08-28

Applicant: Vincent Serra

Inventor： Vincent Serra

IPC: A61K39/00 ,  A61K38/17 ,  C07H15/04 ,  A61K39/39

CPC classification number: A61K39/39 ,  A61K2039/55511

Abstract: The immunogenicity of vaccines is enhanced by co-administering a synthetic glycolipid, designated PBS-57, with the vaccine. PBS-57 has the ability to stimulate both a cell-mediated and humoral immune response. Co-administration of PBS-57 with a vaccine may be used in methods to stimulate one or more of a humoral immune response, a CD4+ T cell response, and a CD8+ cytotoxic T cell response.

Abstract translation: 疫苗的免疫原性通过与疫苗共同施用合成的脂肪（PBS-57）来增强。 PBS-57具有刺激细胞介导和体液免疫应答的能力。 PBS-57与疫苗的共同给药可用于刺激体液免疫应答，CD4 + T细胞应答和CD8 +细胞毒性T细胞应答中的一种或多种的方法。

公开(公告)号：US08907070B2

公开(公告)日：2014-12-09

申请号：US13668632

申请日：2012-11-05

Applicant: Rauzah Hashim ,  Thorsten Heidelberg ,  Hind Hassan ,  Nasrul Zamani Mohd Rodzi ,  Rusnah Syahila Dauli Hussen ,  Ahmad Sazali Hamzah ,  Shahidan Radiman ,  Volkmar Vill ,  Matthias Wulf ,  Seiji Ujiie

Inventor： Rauzah Hashim ,  Thorsten Heidelberg ,  Hind Hassan ,  Nasrul Zamani Mohd Rodzi ,  Rusnah Syahila Dauli Hussen ,  Ahmad Sazali Hamzah ,  Shahidan Radiman ,  Volkmar Vill ,  Matthias Wulf ,  Seiji Ujiie

IPC: C07H15/04 ,  C07H15/08 ,  C09K19/04

CPC classification number: C07H15/04 ,  C09K19/0422

Abstract: Glycolipids of branched chain alkyl oligosaccharides include a primary alcohol branched in the 2-position and an oligosaccharide, covalently bond to the alcohol in either α- or β-linkage (shown in Formula I and Formula II). These compounds show phase behavior not found for the corresponding straight chain counterparts. The properties involve an ambient temperature liquid crystalline appearance and thermotropic liquid crystal phase polymorphism. The formation of cubic phases is considered most interesting with respect to life science applications, e.g. liposomes for drug delivery. Depending on the choice of sugar head group and alkyl tail, various levels of water miscibility may be adjusted to meet applications requirements (complete solubility for emulsifier applications, e.g. cosmetic creams, to limited water swelling only, e.g. for the preparation of artificial membranes). The closed structural relationship to natural lipids also makes branched chain alkyl oligosaccharides valuable subjects for biochemical investigations, e.g. membrane studies.

Abstract translation: 支链烷基寡糖的糖脂包括在2位上分支的伯醇和低聚糖，以α-或β-连接（式I和式II中所示）与醇共价键合。 这些化合物显示相应的直链对应物没有发现的相行为。 性质包括环境温度液晶外观和热致液晶相多态性。 在生命科学应用方面，立方相的形成被认为是最有趣的。 用于药物输送的脂质体。 根据糖头基和烷基尾的选择，可以调节不同水平的水混溶性以满足应用要求（对于乳化剂应用（例如化妆品乳液，仅限于有限的水溶胀，例如制备人造膜）的完全溶解度）。 与天然脂质的封闭结构关系也使支链烷基寡糖成为生物化学研究的有价值的对象，例如。 膜研究。