公开(公告)号：US20220324889A1

公开(公告)日：2022-10-13

申请号：US17833341

申请日：2022-06-06

申请人： Mindset Pharma Inc.

发明人： Abdelmalik Slassi ,  Joseph Araujo

IPC分类号： C07F9/572 ,  C07D209/16 ,  C07D401/14 ,  C07D403/06

摘要： The present application relates to psilocin derivatives of Formula (I), to processes for their preparation, to compositions comprising them and to their use in activation of a serotonin receptor in a cell, as well as to treating diseases, disorders or conditions by activation of a serotonin receptor in a cell.

公开(公告)号：US11465983B2

公开(公告)日：2022-10-11

申请号：US16650727

申请日：2018-09-26

申请人： Dana-Farber Cancer Institute, Inc.

发明人： Sara Buhrlage ,  Kenneth C. Anderson ,  Dharminder Chauhan ,  Sirano Dhe-Paganon ,  Xiaoxi Liu ,  Hyuk-Soo Seo

IPC分类号： C07D401/14 ,  C07D401/06 ,  C07D403/06 ,  C07D413/14

摘要： The present disclosure relates to inhibitors of USP7 useful in the treatment of cancers, and other USP7 mediated diseases, having the Formula: wherein R1, R2, R3, R4, R5, R6, and n are described herein.

公开(公告)号：US11458158B2

公开(公告)日：2022-10-04

申请号：US16867291

申请日：2020-05-05

申请人： Massachusetts Institute of Technology

发明人： Yizhou Dong ,  Kevin Thomas Love ,  Robert S. Langer ,  Daniel Griffith Anderson ,  Delai Chen ,  Yi Chen ,  Arturo Jose Vegas ,  Akinleye C. Alabi ,  Yunlong Zhang

IPC分类号： A61K31/7105 ,  C07D233/64 ,  C07D403/06 ,  C07D241/08 ,  C07C229/12 ,  C07C229/22 ,  C07C229/26 ,  C07D487/06 ,  C07D207/16 ,  C07D209/20 ,  C07C271/22 ,  C07C229/36 ,  C07C237/08 ,  C07C237/12 ,  C12N15/88 ,  C12N15/87 ,  C07C229/24 ,  C07C279/14 ,  C07C323/58 ,  C07D209/24 ,  C07D265/32 ,  C07D413/06 ,  C07D487/04 ,  C12Q1/02 ,  G01N33/15 ,  A61K31/711 ,  A61K47/22

摘要： Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as “APPLs”. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R′, R1, R2, R3, R4, R5, R8, Z, W, Y, and Z are as defined herein.

公开(公告)号：US11453689B2

公开(公告)日：2022-09-27

申请号：US17387864

申请日：2021-07-28

申请人： Mindset Pharma Inc.

发明人： Abdelmalik Slassi ,  Joseph Araujo

IPC分类号： C07D403/06 ,  C07F9/572 ,  A61K31/675

摘要： The present application relates to 3-cyclic amine-indole derivatives of general Formula (I), to processes for their preparation, to compositions comprising them and to their use in activation of a serotonin receptor in a cell, as well as to treating diseases, disorders or conditions by activation of a serotonin receptor in a cell. The diseases, disorders or conditions include, for example, psychosis, mental illnesses, and other neurological diseases, disorders and conditions.

公开(公告)号：US20220298110A1

公开(公告)日：2022-09-22

申请号：US17514578

申请日：2021-10-29

申请人： Venatorx Pharmaceuticals, Inc.

发明人： Christopher J. BURNS ,  Glen COBURN ,  Bin LIU ,  Jiangchao YAO ,  Christopher BENETATOS ,  Steven A. BOYD ,  Stephen M. CONDON ,  Thomas HAIMOWITZ

IPC分类号： C07D207/34 ,  A61P31/20 ,  C07D401/12 ,  C07D405/12 ,  C07D417/12 ,  C07D403/06 ,  C07D498/04 ,  C07D401/06 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D207/337 ,  C07D401/14 ,  C07D405/14 ,  C07D409/12 ,  C07D409/14 ,  C07F5/02

摘要： Described herein are hepatitis B capsid assembly modulators and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of hepatitis B.

公开(公告)号：US11447497B2

公开(公告)日：2022-09-20

申请号：US17256142

申请日：2019-06-28

申请人： HISTOGEN, INC.

发明人： Alfred P. Spada ,  Robert J. Ternansky

IPC分类号： C07D491/048 ,  C07D241/04 ,  C07D241/08 ,  C07D241/38 ,  C07D401/06 ,  C07D403/06 ,  C07D403/12 ,  C07D405/06 ,  C07D409/06 ,  C07D409/12 ,  C07D471/04

摘要： The present invention relates to (S)-3-(2-(4-(benzyl)-3-oxopiperazin-1-yl)acetamido)-4-oxo-5-(2,3,5,6-tetrafluorophenoxy)pentanoic acid derivatives and related compounds as caspase inhibitors for treating e.g. cardiovascular, kidney, liver, lung, skin, joints, CNS, inflammatory and autoimmune diseases.

公开(公告)号：US20220289774A1

公开(公告)日：2022-09-15

申请号：US17743718

申请日：2022-05-13

申请人： Mindset Pharma Inc.

发明人： Abdelmalik Slassi ,  Joseph Araujo

IPC分类号： C07F9/572 ,  C07D209/16 ,  C07D401/14 ,  C07D403/06

摘要： The present application relates to psilocin derivatives of Formula (I), to processes for their preparation, to compositions comprising them and to their use in activation of a serotonin receptor in a cell, as well as to treating diseases, disorders or conditions by activation of a serotonin receptor in a cell.

公开(公告)号：US20220288069A1

公开(公告)日：2022-09-15

申请号：US17626486

申请日：2020-07-17

申请人： BridGene Biosciences, Inc.

发明人： Chao Zhang ,  Ping Cao ,  Michael J. Bishop

IPC分类号： A61K31/506 ,  C07D403/12 ,  C07D413/14 ,  C07D403/14 ,  C07D417/12 ,  C07D417/14 ,  C07D403/06 ,  C07D209/34 ,  A61K45/06 ,  A61K31/5377 ,  A61K31/4439 ,  A61K31/404

摘要： The present disclosure provides compounds and compositions thereof which are useful as inhibitors of tyrosine kinase and which exhibit desirable characteristics for the same. Further disclosed herein are methods of treating cancer using these tyrosine kinase inhibitor compounds.

公开(公告)号：US20220281821A1

公开(公告)日：2022-09-08

申请号：US17737988

申请日：2022-05-05

申请人： Jinan University

发明人： Ke DING ,  Shingpan CHAN ,  Zhang ZHANG ,  Yunxin DUAN ,  Jie WANG ,  Xiaomei REN ,  Zhengchao TU

IPC分类号： C07D231/56 ,  C07D401/06 ,  C07D403/06 ,  C07D409/06 ,  C07D401/14 ,  C07D471/04 ,  A61P35/00

摘要： The present invention provides indazole derivatives or their pharmaceutically acceptable salts or stereoisomers having the structure shown in formula (I), and their pharmaceutical compositions and applications thereof. Such compounds can be used as protein kinase inhibitors, which can effectively inhibit the activity of tropomyosin receptor kinase (TRK) protein kinase and can inhibit the proliferation, migration and invasion of a variety of tumor cells.

公开(公告)号：US20220251047A1

公开(公告)日：2022-08-11

申请号：US17652022

申请日：2022-02-22

申请人： Vettore, LLC

发明人： Kenneth Mark PARNELL ,  John MCCALL ,  Donna ROMERO

IPC分类号： C07D231/14 ,  C07D231/56 ,  A61P35/00 ,  C07D207/24 ,  C07C59/01 ,  C07D205/02 ,  C07D401/04 ,  C07D403/04 ,  C07D403/10 ,  C07D403/14 ,  C07D405/04 ,  C07D405/12 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D213/12 ,  A61K45/06 ,  A61K31/415 ,  C07D403/06 ,  C07D405/06 ,  C07D405/14

摘要： Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the structure of Formula I: Methods of inhibition MCT4 activity in a human or animal subject are also provided.