公开(公告)号：US11369719B2

公开(公告)日：2022-06-28

申请号：US16820688

申请日：2020-03-16

申请人： Barry K. Bartee ,  Richard A. Rosen

发明人： Barry K. Bartee ,  Richard A. Rosen

IPC分类号： A61L31/00 ,  A61L27/24 ,  A61L27/50 ,  A61L27/38 ,  A61L27/54 ,  A61L27/34 ,  A61F2/00 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16

摘要： Biomaterials and methods and uses for repair or augmentation of tissues are provided. In particular, the invention provides a multi-layered, naturally occurring multi-axial oriented biomaterial comprising predominately type I collagen fibers. The invention further provides methods and uses for repair or augmentation of tissues using biomaterials of the invention.

公开(公告)号：US20220151619A1

公开(公告)日：2022-05-19

申请号：US17438373

申请日：2020-03-11

申请人： The Board of Supervisors of Louisiana State University and Agricultural and Mechanical College

发明人： Ian Alexander HODGDON

IPC分类号： A61B17/11 ,  A61L31/00 ,  A61L31/14 ,  A61L31/04

摘要： This invention is directed to an anastomosing stent comprising an internal frame and an external casing, and methods of use thereof.

公开(公告)号：US20220143274A1

公开(公告)日：2022-05-12

申请号：US17435507

申请日：2020-03-03

申请人： Hans Ulrich Baer

发明人： Hans Ulrich Baer

IPC分类号： A61L31/00 ,  A61L31/14 ,  A61L31/06 ,  A61L31/04 ,  A61K35/33 ,  A61L31/16

摘要： A biodegradable mesh implant for use in soft tissue repair, in particular surgical hernia, chronic wound healing or fistula repair, within the body of a patient is disclosed. The mesh implant includes a porous, hydrophilic biodegradable polymeric carrier mesh and fibroblasts on or within the polymeric carrier mesh. The carrier mesh includes a sponge-like structure with interconnected pores of different sizes, has a water contact angle of less than 75° and is made of at least a first polymer comprising polylactic acid as a main component.

公开(公告)号：US20220126076A1

公开(公告)日：2022-04-28

申请号：US17572478

申请日：2022-01-10

申请人： W. L. Gore & Associates, Inc.

发明人： Edward H. Cully ,  Edward Gunzel ,  Keith Knisley ,  Greg Rusch ,  Lauren Zambotti

IPC分类号： A61M31/00 ,  A61F2/02 ,  A61K9/00 ,  A61L31/04 ,  A61L31/14 ,  A61L31/16 ,  A61M39/02

摘要： The present disclosure relates to implantable encapsulation devices for housing a biological moiety or a therapeutic device that contains a biological moiety. Particularly, aspects of the present disclosure are directed to an implantable apparatus that includes a distal end, a proximal end, a manifold including at least one access port positioned either at the distal end or the proximal end, and a plurality of containment tubes affixed to the manifold and in fluid communication with the at least one access port. Additionally, the encapsulation device may contain a flush port and a tube that are fluidly connected to the manifold. The containment tubes may contain therein a biological moiety (e.g., cells) or a therapeutic device (e.g. a cell encapsulation member).

公开(公告)号：US20220088296A1

公开(公告)日：2022-03-24

申请号：US17539445

申请日：2021-12-01

申请人： Boston Scientific Scimed, Inc.

发明人： Samuel Raybin ,  Matthew B. Hollyer

IPC分类号： A61M5/158 ,  A61J1/10 ,  A61K9/00 ,  A61K9/06 ,  A61M5/178 ,  A61K47/36 ,  A61L31/04 ,  A61L31/14

摘要： A medical device comprising a syringe barrel, a plunger, and an injectable gel containing a coloring agent loaded in the syringe barrel. The injectable gel is sterilized by a sterilization process, such as an autoclaving process, while inside the syringe barrel. The injectable gel is adapted for injection between an upper mucosal layer and a lower layer at a target treatment site such that the upper mucosal layer separates from the lower layer and the upper mucosal layer is elevated. Also described herein are methods of forming the injectable gel.

公开(公告)号：US20220087811A1

公开(公告)日：2022-03-24

申请号：US17457246

申请日：2021-12-01

申请人： Healionics Corporation

发明人： Andrew J. Marshall ,  Max Maginness ,  Adrienne Oda ,  Brandt Scanlan

IPC分类号： A61F2/06 ,  A61L31/14 ,  A61L31/04 ,  A61F2/00

摘要： This disclosure provides prosthetic arteriovenous grafts having a blood-contacting layer; an intermediate layer; and a tissue-interface layer formed of a microporous biomaterial with a textured microporous surface, the prosthetic arteriovenous grafts providing vascular access for hemodialysis and being capable of reducing perigraft fibrotic capsular formation, and a method of maintaining the patency of the prosthetic arteriovenous grafts.

公开(公告)号：US20220079579A1

公开(公告)日：2022-03-17

申请号：US17532133

申请日：2021-11-22

申请人： Cilag GmbH International

发明人： Frederick E. Shelton, IV ,  Jason L. Harris ,  Michael J. Vendely ,  Peyton Hopson ,  Rao Bezwada ,  Chester O. Baxter, III ,  Mark S. Zeiner

IPC分类号： A61B17/064 ,  B33Y10/00 ,  B29C64/153 ,  A61B17/072 ,  A61L31/06 ,  A61L31/14 ,  A61L31/16 ,  B33Y80/00 ,  A61L31/04 ,  B33Y70/00

摘要： Stapling assemblies for use with a surgical stapler and methods for manufacturing the same are provided. Three dimensional adjuncts for use with a surgical stapling assembly and methods for manufacturing the same are also provided.

公开(公告)号：US11266682B2

公开(公告)日：2022-03-08

申请号：US16887100

申请日：2020-05-29

申请人： Anatoli D. Dosta

发明人： Anatoli D. Dosta

IPC分类号： A01N35/06 ,  A61K31/755 ,  A61L31/04

摘要： The invention concerns medical applications and can be used in oncology, as well as in neurosurgery, traumatology, neurology, rehabilitation. The aim of the inventions claimed is the creation of a new method of local exposure on biological tissues and a new tissue-substitute applicator that benefits to both destruction and replacement of tumor tissue by restored biological tissue with no external exposure applied (alternating magnetic field, heating, etc.) The aim set is solved by using porous polytetrafluoroethylene as a cytostatic material. The aim set is also achieved by using porous polytetrafluoroethylene in production of a tissue-substitute applicator for treating or replacing tumor tissues. The aim set for the method of local exposure to biological tissues, including the placement of a tissue-substitute polymeric applicator in direct contact with the biological tissue to be exposed, is solved by using porous polytetrafluoroethylene for the constituent polymeric material.

公开(公告)号：US11266339B2

公开(公告)日：2022-03-08

申请号：US16408122

申请日：2019-05-09

申请人： Trustees of Tufts College

发明人： David L. Kaplan ,  Lee W. Tien ,  Gary G. Leisk ,  Tim Jia-Ching Lo ,  Cinzia Metallo ,  Fiorenzo Omenetto

IPC分类号： A61L31/10 ,  A61B5/291 ,  A61B5/00 ,  A61L27/22 ,  A61L27/36 ,  A61L31/04 ,  A61L31/14 ,  A61N1/05 ,  A61L31/16

摘要： Provided herein relates to implantable devices and systems with dynamic silk coatings. In some embodiments, the dynamic silk coatings can be formed in situ or in vivo.

公开(公告)号：US20220023503A9

公开(公告)日：2022-01-27

申请号：US16418063

申请日：2019-05-21

申请人： Aziyo Med, LLC

发明人： Robert G Matheny

IPC分类号： A61L27/36 ,  A61L27/38 ,  A61L31/16 ,  A61F2/02 ,  A61L27/22 ,  A61L27/54 ,  A61L31/14 ,  A61L27/50 ,  A61L31/04 ,  A61N1/375 ,  A61L31/00 ,  A61L27/34 ,  A61F2/00

摘要： Tissue prostheses having a base structure and a physiological sensor system. The tissue prostheses are adapted and configured to induce remodeling of damaged tissue and regeneration of new tissue and concurrently detect and monitor physiological characteristics when implanted in the subject.