公开(公告)号：US08178677B2

公开(公告)日：2012-05-15

申请号：US11885005

申请日：2006-02-22

Applicant: Tushar A. Kshirsagar ,  Bryon A. Merrill ,  Scott E. Langer ,  Kyle J. Lindstrom ,  Sarah J. Slania ,  Gregory J. Marszalek ,  Karl J. Manske ,  Philip D. Heppner ,  Gregory D. Lundquist, Jr.

Inventor： Tushar A. Kshirsagar ,  Bryon A. Merrill ,  Scott E. Langer ,  Kyle J. Lindstrom ,  Sarah J. Slania ,  Gregory J. Marszalek ,  Karl J. Manske ,  Philip D. Heppner ,  Gregory D. Lundquist, Jr.

IPC: C07D471/00 ,  A61K31/535

CPC classification number: C07D471/04

Abstract: Certain imidazoquinolines with a hydroxymethyl or hydroxyethyl substituent at the 2-position, pharmaceutical compositions containing the compounds, intermediates, methods of making and methods of use of these compounds as immunomodulators, for preferentially inducing IFN-α biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.

Abstract translation: 具有2-位羟基甲基或羟乙基取代基的某些咪唑并喹啉，含有化合物的药物组合物，中间体，制备方法以及这些化合物作为免疫调节剂的使用方法，用于优先诱导动物中的IFN-α生物合成和治疗疾病 包括病毒和肿瘤疾病。

公开(公告)号：US07981995B2

公开(公告)日：2011-07-19

申请号：US12563311

申请日：2009-09-21

Applicant: David S. Hays ,  Richard G. Hansen ,  Stephen A. Johnson ,  Benjamin J. Bending ,  Kyle J. Lindstrom

Inventor： David S. Hays ,  Richard G. Hansen ,  Stephen A. Johnson ,  Benjamin J. Bending ,  Kyle J. Lindstrom

IPC: C08G77/06

CPC classification number: C07C251/66 ,  C08G77/455

Abstract: Silicone polyoxamide and silicone polyoxamide-hydrazide copolymers comprise at least two repeating units of formula I In this formula, each R1 is independently an alkyl, haloalkyl, aralkyl, alkenyl, aryl, or aryl substituted with an alkyl, alkoxy, or halo; each Y is independently an alkylene, aralkylene, or a combination thereof; each G is independently a bond or a divalent residue equal to a diamine of formula R3HN-G-NHR3 minus the two —NHR3 groups; each R3 is independently hydrogen or alkyl or R3 taken together with G and with the nitrogen to which they are both attached form a heterocyclic group; each n is independently an integer of 0 to 1500; each p is independently an integer of 1 to 10, and the average of p is 1.2 or greater; and each q is independently an integer of 1 or greater, and every q is not the same integer.

Abstract translation: 硅氧烷聚酰胺和硅氧烷聚酰胺 - 酰肼共聚物包含至少两个式I的重复单元。在该式中，每个R 1独立地为烷基，卤代烷基，芳烷基，烯基，芳基或被烷基，烷氧基或卤素取代的芳基; 每个Y独立地是亚烷基，亚芳基或其组合; 每个G独立地是等于式R3HN-G-NHR3的二胺减去两个-NHR 3基团的键或二价残基; 每个R 3独立地为氢或烷基或R 3与G一起并与它们所连接的氮形成杂环基; 每个n独立地为0至1500的整数; 每个p独立地为1〜10的整数，p的平均值为1.2以上; 并且每个q独立地为1或更大的整数，并且每个q不是相同的整数。

公开(公告)号：US20090275720A1

公开(公告)日：2009-11-05

申请号：US12112425

申请日：2008-04-30

Applicant: Bryan V. Hunt ,  Kyle J. Lindstrom

Inventor： Bryan V. Hunt ,  Kyle J. Lindstrom

IPC: C08F220/30

CPC classification number: C08F220/30 ,  C08K5/105

Abstract: Optical films having a polymerized microstructured surface and polymerizable resin compositions are described comprising at least one ortho-benzylphenol mono(meth)acrylate monomer.

Abstract translation: 描述了具有聚合的微结构化表面和可聚合树脂组合物的光学膜包含至少一种邻苯甲基苯酚单（甲基）丙烯酸酯单体。

公开(公告)号：US20090124652A1

公开(公告)日：2009-05-14

申请号：US11813007

申请日：2005-12-28

Applicant: David Ach ,  Hughes Martin ,  Anna Van ,  Joel R. Jacobson ,  Junshi Y. Wu ,  Kyle J. Lindstrom ,  Tai T. Tran ,  Myles L. Brostrom ,  Michael J. Rice ,  Raymond D. Skwierczynski

Inventor： David Ach ,  Hughes Martin ,  Anna Van ,  Joel R. Jacobson ,  Junshi Y. Wu ,  Kyle J. Lindstrom ,  Tai T. Tran ,  Myles L. Brostrom ,  Michael J. Rice ,  Raymond D. Skwierczynski

IPC: A61K31/4375 ,  C07D471/14 ,  A61P35/00

CPC classification number: C07D471/14

Abstract: The invention provides various crystalline forms of 1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine ethanesulfonate, pharmaceutical compositions, methods of making, and methods of use.

Abstract translation: 本发明提供各种结晶形式的1-（2-甲基丙基）-1H-咪唑并[4,5-c] [1,5]萘啶-4-胺乙磺酸盐，药物组合物，制备方法和使用方法。

公开(公告)号：US20080312434A1

公开(公告)日：2008-12-18

申请号：US12113776

申请日：2008-05-01

Applicant: Kyle J. Lindstrom ,  Luke T. Dressel ,  Jason D. Bonk

Inventor： Kyle J. Lindstrom ,  Luke T. Dressel ,  Jason D. Bonk

IPC: C07D487/12

CPC classification number: C07D471/04 ,  C07D471/14

Abstract: A process and intermediates for preparing 1H-imidazo[4,5-c]pyridin-4-amines are disclosed. The process includes providing a 7H-imidazo[4,5-c]tetrazolo[1,5-a]pyridine and converting a 7H-imidazo[4,5-c]tetrazolo[1,5-a]pyridine to a 1H-imidazo[4,5-c]pyridin-4-amine.

Abstract translation: 公开了制备1H-咪唑并[4,5-c]吡啶-4-胺的方法和中间体。 该方法包括提供7H-咪唑并[4,5-c]四唑并[1,5-a]吡啶，并将7H-咪唑并[4,5-c]四唑并[1,5-a]吡啶转化为1H- 咪唑并[4,5-c]吡啶-4-胺。

公开(公告)号：US06720422B2

公开(公告)日：2004-04-13

申请号：US10357733

申请日：2003-02-04

Applicant: Joseph F. Dellaria ,  Chad A. Haraldson ,  Kyle J. Lindstrom ,  Bryon A. Merrill

Inventor： Joseph F. Dellaria ,  Chad A. Haraldson ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC: C07D47104

CPC classification number: C07D471/04

Abstract: Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Abstract translation: 在1位含有酰胺官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

公开(公告)号：US06720333B2

公开(公告)日：2004-04-13

申请号：US10357995

申请日：2003-02-04

Applicant: Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

Inventor： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC: A61K31437

CPC classification number: C07D471/04

Abstract: Imidazopyridine compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US06545017B1

公开(公告)日：2003-04-08

申请号：US10165453

申请日：2002-06-07

Applicant: Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

Inventor： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC: A61K31437

CPC classification number: C07D471/04

Abstract: Imidazopyridine compounds that contain urea or thiourea functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

公开(公告)号：US5482936A

公开(公告)日：1996-01-09

申请号：US371845

申请日：1995-01-12

Applicant: Kyle J. Lindstrom

Inventor： Kyle J. Lindstrom

IPC: C07D471/04 ,  A61K31/435 ,  A61K31/535 ,  A61K31/55 ,  A61P31/12 ,  A61P37/00 ,  C07D471/14 ,  C07D498/14 ,  A61K31/47

CPC classification number: C07D471/14

Abstract: Compounds and pharmaceutically acceptable salts thereof formally derived by bridging the 1- and 2-positions of 1H-imidazo[4,5-c]quinolin-4-amines. Also, methods of using such compounds and pharmaceutical formulations containing such compounds. Said compounds are useful to induce interferon biosynthesis in an animal.

Abstract translation: 通过桥接1H-咪唑并[4,5-c]喹啉-4-胺的1-位和2-位形成的化合物及其药学上可接受的盐。 此外，使用这些化合物的方法和含有这些化合物的药物制剂。 所述化合物可用于在动物中诱导干扰素生物合成。

公开(公告)号：US08871782B2

公开(公告)日：2014-10-28

申请号：US10595230

申请日：2004-10-01

Applicant: Kyle J. Lindstrom ,  Bryon A. Merrill ,  Chad A. Haraldson ,  Michael J. Rice ,  Tushar A. Kshirsagar ,  Philip D. Heppner ,  Joshua R. Wurst ,  Shri Niwas ,  Sarah C. Johannessen

Inventor： Kyle J. Lindstrom ,  Bryon A. Merrill ,  Chad A. Haraldson ,  Michael J. Rice ,  Tushar A. Kshirsagar ,  Philip D. Heppner ,  Joshua R. Wurst ,  Shri Niwas ,  Sarah C. Johannessen

IPC: A61K31/437 ,  C07D471/06 ,  C07D471/04

CPC classification number: C07D471/04 ,  A61K31/4745 ,  C07D413/14 ,  C07D519/00 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/463

Abstract: Imidazoquinoline compounds with an alkoxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral, and neoplastic, are disclosed.

Abstract translation: 含有6,7,8或9位烷氧基取代基的咪唑并喹啉化合物含有化合物，中间体，制备方法，以及这些化合物作为免疫调节剂的用途，用于诱导或抑制动物中的细胞因子生物合成， 在包括病毒和肿瘤的疾病的治疗中。