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    Carbon-based surface plasmon source and applications thereof
    81.
    发明授权
    Carbon-based surface plasmon source and applications thereof 有权

    公开(公告)号：US10459257B2

    公开(公告)日：2019-10-29

    申请号：US15048520

    申请日：2016-02-19

    Applicant: Monash University

    Inventor： Chanaka Rupasinghe ,  Malin Premaratne ,  Ivan D. Rukhlenko

    IPC: A61K41/00 ,  G02F1/00 ,  A61N1/10 ,  A61N5/06 ,  B82Y20/00

    Abstract: A spaser device comprises a graphene resonator and a carbon nanotube (CNT) gain element coupled via exciton-plasmon interaction. The graphene resonator may be a rectangular or square graphene nanoflake (GNF), and the CNT gain element may be characterized by chirality vector (n,m) selected such that the CNT has semiconducting properties. The CNT gain element may be illuminated using a light source having a photon energy corresponding with a first exciton energy (E22) of the CNT, whereby excitons having a second exciton energy (E11) less than the first exciton energy are generated in the CNT, and coupled to a surface plasmon (SP) mode of the graphene resonator. When the rate of generation of excitons having the second exciton energy exceeds a gain threshold, continuous spasing is established within the spaser device.

    Constrained proteins and uses therefor
    82.
    发明授权
    Constrained proteins and uses therefor 有权

    公开(公告)号：US10294280B2

    公开(公告)日：2019-05-21

    申请号：US15327759

    申请日：2015-07-21

    Applicant: Monash University

    Inventor： Fasseli Joseph Coulibaly

    IPC: C07K14/005 ,  A61K39/12 ,  A61K39/00

    Abstract: A fusion protein comprising an N-terminal portion and a C-terminal portion, wherein the N-terminal portion is a heterologous protein of interest which includes membrane proteins and antigens and the C-terminal portion is a polyhedrin targeting peptide which is derived from cypovirus polyhedrin and binds to cypovirus polyhedrin. The polyhedrin targeting peptide is described as a C-terminal portion of cypovirus polyhedrin and as C-terminal portion of cypovirus polyhedrin absent all or part of the N-terminal H1 helix sequence. Vectors and cells capable of expressing the fusion proteins are also provided. The fusion proteins fold with cypovirus polyhedrin to form modified complexes, polyhedra/microcubes useful in myriad applications, including as a platform technology for prophylactic or therapeutic vaccinations, therapeutics and diagnostics, including vaccines, therapeutics and diagnostics etc. employing membrane proteins.

    IL-21 Antibodies
    83.
    发明申请
    IL-21 Antibodies 审中-公开

    公开(公告)号：US20190111148A1

    公开(公告)日：2019-04-18

    申请号：US15537095

    申请日：2015-12-15

    Applicant: Monash University

    Inventor： Charles Reay Mackay ,  Di Yu ,  Remy Robert

    IPC: A61K47/68 ,  A61K38/20 ,  C07K16/24

    Abstract: The invention relates to IL-21, to antibodies and related fragments thereof for binding to IL-21, to production of said antibodies and fragments and to use of said antibodies and fragments for detection and therapy of various conditions, in particular inflammation, infection and oncology.

    METHODS AND COMPOSITIONS FOR IMPROVING GLUCOSE METABOLISM
    87.
    发明申请
    METHODS AND COMPOSITIONS FOR IMPROVING GLUCOSE METABOLISM 审中-公开

    公开(公告)号：US20180362602A1

    公开(公告)日：2018-12-20

    申请号：US15771980

    申请日：2016-10-28

    Applicant: MONASH UNIVERSITY

    Inventor： Matthew WATT ,  Ruth MEEX

    IPC: C07K14/47 ,  A61P3/10 ,  C07K16/46

    CPC classification number: C07K14/4702 ,  A61K38/1709 ,  A61P3/10 ,  C07K16/46 ,  C07K2319/30

    Abstract: The present invention relates to compositions, methods and kits for promoting glucose clearance in an individual. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment of insulin resistance or type 2 diabetes. The invention provides a method of promoting blood glucose clearance in an individual, the method comprising administering SMOC1 to the individual. Preferably, the individual has an impaired ability to clear glucose from the blood. Typically, the individual displays a level of insulin resistance.

    Carbon-Based Surface Plasmon Source And Applications Thereof
    90.
    发明申请
    Carbon-Based Surface Plasmon Source And Applications Thereof 审中-公开

    公开(公告)号：US20180252947A1

    公开(公告)日：2018-09-06

    申请号：US15048520

    申请日：2016-02-19

    Applicant: Monash University

    Inventor： Chanaka Rupasinghe ,  Malin Premaratne ,  Ivan D. Rukhlenko

    IPC: G02F1/00 ,  A61N5/06 ,  A61N1/10

    CPC classification number: G02F1/0081 ,  A61K41/00 ,  A61K41/0023 ,  A61K41/0057 ,  A61N1/10 ,  A61N5/06 ,  A61N5/062 ,  B82Y20/00

    Abstract: A spaser device comprises a graphene resonator and a carbon nanotube (CNT) gain element coupled via exciton-plasmon interaction. The graphene resonator may be a rectangular or square graphene nanoflake (GNF), and the CNT gain element may be characterised by chirality vector (n,m) selected such that the CNT has semiconducting properties. The CNT gain element may be illuminated using a light source having a photon energy corresponding with a first exciton energy (E22) of the CNT, whereby excitons having a second exciton energy (E11) less than the first exciton energy are generated in the CNT, and coupled to a surface plasmon (SP) mode of the graphene resonator. When the rate of generation of excitons having the second exciton energy exceeds a gain threshold, continuous spasing is established within the spaser device.

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