Abstract:
The invention relates to methods and compositions for inhibiting metastasis, such as by inhibiting FOXC2 expression or activity. The invention further relates to methods of prognosticating, diagnosing, and assisting in the diagnosis of metastasis in an individual, or of determining the metastatic potential of a tumor. The invention further relates to methods of identifying agents which inhibit metastasis.
Abstract:
Ghrelin O-acyltransferase (GOAT) is inhibited with designed small molecules. Methods comprise contacting the GOAT with an inhibitor and detecting a resultant inhibition.
Abstract:
A method and device for estimating a Gaussian white noise power in a channel and a receiver are provided. The method includes performing a multi-path search on a received signal to find out paths of the signal; performing a noise estimation on one of the paths to acquire a total noise power of the path; performing an inter-path interference noise estimation on N paths spaced apart from the path by an integral number of chips to obtain an inter-path interference noise power of a single path of the signal, where N is an integer greater than or equal to 1; and subtracting the inter-path interference noise power from the total noise power to obtain the Gaussian white noise power. Through the technical solution of the disclosure, the Gaussian white noise power in a channel is obtained with a higher accuracy, so that the performance of equalization is enhanced.
Abstract:
Ghrelin is acylated ghrelin O-acyltransferase. Ghrelin O-acyltransferase assays comprise contacting a mixture of ghrelin and recombinant ghrelin O-acyltransferase with an agent; and detecting a resultant decrease in acylation of the ghrelin by the acyltransferase.
Abstract:
A method (50) and apparatus (40) for reducing noise in a video signal calculates (53) a discrimination value of a filter based on a magnitude difference between a current frame and a prior frame of a sequence of frames and modifies (54) the current frame using the modified discrimination value. The output of the filter is calculated as follows: g(i, j, k)=f(i, j, k)±β wherein: f (i, j, k) is the current frame input to the filter; g(i, j, k) is the current frame output from the filter; and β is the discrimination value of the filter, which is calculated as follows: β = { κδ ′ + χ , δ ′ = max { δ , δ 0 } , δ
Abstract:
4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.
Abstract:
Transgenic mice expressing human tissue factor which are useful for evaluating pharmacologic agents which interact with human tissue factor and for investigating diseases associated with human tissue factor.
Abstract:
4-Biarylyl-1-phenylazetidin-2-ones useful for the treatment of hypercholesterolemia are disclosed. The compounds are of the general formula in which represents an aryl or heteroaryl residue; Ar represents an aryl residue; U is a two to six atom chain; and the R's represent substituents.
Abstract:
A family of electrophilic trifluoromethylating reagents which can be synthesized by comparatively simple, inexpensive routes, and for which the reactivity can be varied according to need. A composition of matter according to the first embodiment of the invention comprises a compound having the formula: in which A comprises H or F and B comprises F, SCF3, OCF3, OCHF2, S+(CF3)C6H5, NO2 or an NO2 substituent. In a second embodiment of the invention, a process for preparing a trifluoromethyl diphenylsulfonium triflate compound corresponding to the formula shown above comprises reacting phenyl trifluoromethyl sulfoxide or one of its derivatives with an aromatic compound in which A comprises H or F and B comprises H, F, SCF3, OCF3, OCHF2, S+(CF3)C6H5, NO2 or an NO2 substituent. In a third embodiment of the invention, a trifluoromethylation process comprises reacting a trifluoromethyl diphenylsulfonium triflate corresponding to the formula shown above with an electron rich substrate.
Abstract:
FIG. 1 is a perspective view of a pet protective collar showing my new design; FIG. 2 is another perspective view thereof; FIG. 3 is a front elevational view thereof; FIG. 4 is a rear elevational view thereof; FIG. 5 is a left side elevational view thereof; FIG. 6 is a right side elevational view thereof; FIG. 7 is a top plan view thereof; and, FIG. 8 is a bottom plan view thereof. The broken lines in the drawings depict portions of the pet protective collar that form no part of the claimed design.