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公开(公告)号：US09623093B2
公开(公告)日：2017-04-18
申请号：US14620548
申请日：2015-02-12
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C07K14/47 , C07K14/35 , A61K38/53 , C12N9/10 , C12N9/00 , G01N33/50 , G01N33/68 , C12N9/96 , A61K35/12 , C07K14/00 , G01N33/573 , A61K38/00
CPC分类号： C07K16/40 , A61K35/12 , A61K38/00 , A61K38/53 , C07K14/00 , C07K2317/24 , C07K2317/34 , C07K2319/33 , C12N9/1085 , C12N9/93 , C12N9/96 , C12Y601/01 , G01N33/5008 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/00
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US09528103B2
公开(公告)日：2016-12-27
申请号：US14593613
申请日：2015-01-09
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C07K16/40 , C12N9/00 , G01N33/573 , A61K38/00
CPC分类号： C07K16/40 , A61K38/00 , A61K39/39591 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/92 , C07K2319/00 , C12N9/93 , C12Y601/01 , C12Y601/01005 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
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公开(公告)号：US09499810B2
公开(公告)日：2016-11-22
申请号：US14180126
申请日：2014-02-13
申请人： aTyr Pharma, Inc.
CPC分类号： A61K38/53 , C12N9/93 , C12N9/96 , C12Y601/01001 , Y02A50/385
摘要： Thrombopoietic compositions are provided comprising tyrosyl tRNA synthetase polypeptides, including truncations and/or variants thereof. Also provided are methods of using such compositions in the treatment of conditions that benefit from increased thrombopoiesis, such as thrombocytopenia.
摘要翻译： 提供了包含酪氨酰tRNA合成酶多肽（包括其截短和/或变体）的造血组合物。 还提供了使用这些组合物治疗有益于增加血小板生成（例如血小板减少症）的病症的方法。
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84.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-trna synthetases 有权与酪氨酰-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09428743B2
公开(公告)日：2016-08-30
申请号：US14684052
申请日：2015-04-10
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C07K16/40 , G01N33/573 , A61K38/16 , A61K38/00 , C12N9/00
CPC分类号： C07K16/40 , A61K38/00 , A61K38/16 , C07K2317/24 , C07K2317/622 , C07K2317/92 , C12N9/93 , C12Y601/01 , C12Y601/01001 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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85.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl tRNA synthetases 有权与丙氨酰tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09320782B2
公开(公告)日：2016-04-26
申请号：US14620817
申请日：2015-02-12
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain P. Vasserot , Wing-Sze Lo , Jeffry D. Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C12N9/00 , C12N15/00 , A61K38/53 , C12N9/18 , G01N33/50 , G01N33/68 , C07K16/40 , C12N5/071 , C12N9/96 , A61K35/12 , C07K14/00 , G01N33/573 , A61K38/00
CPC分类号： C07K16/40 , A61K35/12 , A61K38/00 , A61K38/53 , C07K14/00 , C07K2317/24 , C07K2317/622 , C07K2319/33 , C12N5/0602 , C12N9/18 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/01007 , G01N33/5008 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/00
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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86.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases 有权与谷氨酰胺酰-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09068177B2
公开(公告)日：2015-06-30
申请号：US13700410
申请日：2011-05-26
申请人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C07K16/40 , A61K9/0019 , A61K38/00 , C07K2317/24 , C07K2317/34 , C07K2317/92 , C12N9/93 , C12Y601/01 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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87.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases 有权与亮氨酰-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09034598B2
公开(公告)日：2015-05-19
申请号：US13698577
申请日：2011-05-16
申请人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Jeffry D. Watkins , Cheryl L. Quinn , Wing-Sze Lo , John D. Mendlein
IPC分类号： A61K38/00 , C12N9/00 , C12Q1/527 , G01N33/573 , A61K39/00
CPC分类号： C12N9/93 , A61K38/00 , A61K38/53 , A61K2039/505 , C07K16/40 , C12Q1/527 , C12Y601/01 , G01N33/573
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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88.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl-tRNA synthetases 有权与丙氨酰-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US08993723B2
公开(公告)日：2015-03-31
申请号：US13643753
申请日：2011-04-28
申请人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
IPC分类号： C07K1/00 , A61K38/00 , C07K16/40 , C12N9/18 , C12N9/00 , G01N33/50 , G01N33/68 , C12N5/071 , C12N9/96
CPC分类号： C07K16/40 , A61K35/12 , A61K38/00 , A61K38/53 , C07K14/00 , C07K2317/24 , C07K2317/622 , C07K2319/33 , C12N5/0602 , C12N9/18 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/01007 , G01N33/5008 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/00
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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89.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases 有权与Asparaginyl tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US08986680B2
公开(公告)日：2015-03-24
申请号：US13643745
申请日：2011-04-28
申请人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C07K16/40 , A61K35/12 , A61K38/00 , A61K38/53 , C07K14/00 , C07K2317/24 , C07K2317/34 , C07K2319/33 , C12N9/1085 , C12N9/93 , C12N9/96 , C12Y601/01 , G01N33/5008 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/00
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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90.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl tRNA synthetases 有权与异亮氨酸tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US08961960B2
公开(公告)日：2015-02-24
申请号：US13643738
申请日：2011-04-27
申请人： Kyle P. Chiang , Jeffry Dean Watkins , Alain Philippe Vasserot , Cheryl L. Quinn , John D. Mendlein , Wing-Sze Lo , Fei Hong , Leslie Ann Greene
发明人： Kyle P. Chiang , Jeffry Dean Watkins , Alain Philippe Vasserot , Cheryl L. Quinn , John D. Mendlein , Wing-Sze Lo , Fei Hong , Leslie Ann Greene
CPC分类号： C07K16/40 , A61K38/00 , A61K39/39591 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/92 , C07K2319/00 , C12N9/93 , C12Y601/01 , C12Y601/01005 , G01N33/573 , G01N2333/9015
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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