公开(公告)号：US10676422B2

公开(公告)日：2020-06-09

申请号：US15526763

申请日：2015-08-08

申请人： Zhejiang Jiuzhou Pharmaceutical Co., Ltd

发明人： Qilin Zhou ,  Jianhua Xie ,  Xiaohui Yang ,  Lixin Wang

IPC分类号： C07C69/675 ,  C07C29/149 ,  C07C31/20 ,  C07C67/48 ,  B01J31/18 ,  B01J31/24 ,  C07B53/00 ,  C07B57/00 ,  C07D211/02 ,  C07D211/12 ,  C07D305/06 ,  C07D309/06 ,  C07D473/06 ,  C07D309/30 ,  C07C69/732 ,  C07C69/708 ,  C07C33/26

摘要： The present invention relates to kinetic resolution of racemic δ-hydroxyl ester via asymmetric catalytic hydrogenation and an application thereof. In the presence of chiral spiro pyridyl phosphine ligand Iridium catalyst and base, racemic δ-hydroxyl esters were subjected to asymmetric catalytic hydrogenation to obtain extent optical purity chiral δ-hydroxyl esters and corresponding 1,5-diols. An optically active chiral δ-hydroxyl ester and 1,5-diols can be obtained at very high enantioselectivity and yield with relatively low usage of catalyst. The chiral δ-hydroxyl ester and 1,5-diols obtained by using the method can be used as a critical raw material for asymmetric synthesis of chiral drugs (R)-lisofylline and natural drugs (+)-civet, (−)-indolizidine 167B and (−)-coniine.

公开(公告)号：US20200147597A1

公开(公告)日：2020-05-14

申请号：US16740764

申请日：2020-01-13

申请人： Dmitri GOUSSEV ,  Denis SPASYUK

发明人： Dmitri GOUSSEV ,  Denis SPASYUK

IPC分类号： B01J31/24 ,  C07C209/70 ,  C07C41/18 ,  C07C29/149 ,  C01B3/02 ,  B01J31/22 ,  B01J31/20 ,  C07F15/00 ,  C07B31/00 ,  C07F9/58

摘要： The present application discloses complexes useful as catalysts for organic chemical synthesis including hydrogenation and dehydrogenation of unsaturated compounds or dehydrogenation of substrates. The range of hydrogenation substrate compounds includes esters, lactones, oils and fats, resulting in alcohols, diols, and triols as reaction products. The catalysts of current application can be used to catalyze a hydrogenation reaction under solvent free conditions. The present catalysts also allow the hydrogenation to proceed without added base, and it can be used in place of the conventional reduction methods employing hydrides of the main-group elements. Furthermore, the catalysts of the present application can catalyze a dehydrogenation reaction under homogenous and/or acceptorless conditions. As such, the catalysts provided herein can be useful in substantially reducing cost and improving the environmental profile of manufacturing processes for variety of chemicals.

公开(公告)号：US20200147596A1

公开(公告)日：2020-05-14

申请号：US16741987

申请日：2020-01-14

申请人： Dow Global Technologies LLC

发明人： Helene N. Launay ,  Jessica L. Klinkenberg ,  John R. Briggs ,  Sarah E. House ,  Marcel C. Van Engelen ,  Larry G. Wright ,  Georg Bar ,  Wilma Hensen ,  Julia Fuertes Cabello ,  Istvan Lengyel

IPC分类号： B01J31/24 ,  C07F15/00

摘要： Use a solvent blend that contains 1methoxy-2,7-octadiene and an alkanols rather than the alkanols by itself to prepare a catalyst precursor suitable for use in butadiene telomerization.

公开(公告)号：US10604457B2

公开(公告)日：2020-03-31

申请号：US15394317

申请日：2016-12-29

申请人： Chevron Phillips Chemical Company LP

发明人： Steven M. Bischof ,  Brooke L. Small ,  Ryan W. Snell ,  Ron D. Knudsen ,  Eric J. Netemeyer ,  Orson L. Sydora ,  Jamie N. Sutherland ,  Bruce E. Kreischer ,  William J. Fisher

IPC分类号： C07C2/32 ,  C07C2/34 ,  B01J31/24 ,  B01J31/14 ,  C07C2/36

摘要： A process comprising a) contacting (i) ethylene, (ii) a catalyst system comprising 1) a heteroatomic ligand iron salt complex, or a heteroatomic ligand and an iron salt, (iii) hydrogen, and (iv) optionally an organic reaction medium; and b) forming an oligomer product wherein 1) the oligomer product has a Schulz-Flory K value from 0.4 to 0.8 and 2) the oligomer product comprises (a) less than 1 wt. % of polymer, (b) less than 1 wt. % compounds having greater than 70 carbon atoms, (c) less than 1 wt. % compounds having a weight average molecular weight of greater than 1000 g/mol, or (d) any combination thereof wherein the weight percentage is based on the total weight of the oligomer product.

公开(公告)号：US10583427B2

公开(公告)日：2020-03-10

申请号：US14239179

申请日：2012-08-20

申请人： Dmitri Goussev ,  Denis Spasyuk

发明人： Dmitri Goussev ,  Denis Spasyuk

IPC分类号： B01J31/00 ,  B01J31/24 ,  C07F15/00 ,  C07F9/58 ,  C07B31/00 ,  B01J31/20 ,  B01J31/22 ,  C01B3/02 ,  C07C29/149 ,  C07C41/18 ,  C07C209/70 ,  B01J31/18

摘要： The present application discloses complexes useful as catalysts for organic chemical synthesis including hydrogenation and dehydrogenation of unsaturated compounds or dehydrogenation of substrates. The range of hydrogenation substrate compounds includes esters, lactones, oils and fats, resulting in alcohols, diols, and triols as reaction products. The catalysts of current application can be used to catalyze a hydrogenation reaction under solvent free conditions. The present catalysts also allow the hydrogenation to proceed without added base, and it can be used in place of the conventional reduction methods employing hydrides of the main-group elements. Furthermore, the catalysts of the present application can catalyze a dehydrogenation reaction under homogenous and/or acceptorless conditions. As such, the catalysts provided herein can be useful in substantially reducing cost and improving the environmental profile of manufacturing processes for variety of chemicals.

公开(公告)号：US10550138B2

公开(公告)日：2020-02-04

申请号：US15572160

申请日：2016-01-16

申请人： Zhejiang Jiuzhou Pharmaceutical Co., Ltd.

发明人： Qilin Zhou ,  Jianhua Xie ,  Denghui Bao ,  Lixin Wang

IPC分类号： B01J37/04 ,  C07B53/00 ,  C07C29/145 ,  C07C29/149 ,  C07C67/31 ,  C07C69/675 ,  C07C69/708 ,  C07C231/12 ,  C07C231/18 ,  C07C235/06 ,  C07C269/06 ,  C07C271/22 ,  C07F9/50 ,  C07F15/00 ,  B01J31/18 ,  B01J31/22 ,  C07F9/6553 ,  B01J31/24

摘要： The present invention relates to a chiral spiro phosphine-nitrogen-sulfur (P—N—S) tridentate ligand, preparation method and application thereof. The P—N—S tridentate ligand is a compound represented by Formula I or Formula II, their racemates, optical isomers, or catalytically acceptable salts thereof. The ligand has a primary structure skeleton characterized as a chiral spiro indan skeleton structure with a thio group. The chiral spiro phosphine-nitrogen-sulfur tridentate ligand can be synthesized by reacting racemic or optical active compound 7-diary/alkyl phosphine-7′-amino-1, 1′-spiro-dihydro-indene compound having a spiro-dihydro-indene skeleton as the starting material. The chiral spiro P—N—S tridentate ligand being complex with transition metal salt can be used in an asymmetric catalytic hydrogenation reaction for catalyzing carbonyl compound. In particular, in asymmetric hydrogenation reaction process, being complex with iridium for catalyzing β-alkyl-β-keto ester can obtain a high catalytic activity (a catalyst amount of 0.0002% mol) and high enantioselectivity (up to 99.9% ee) result. So the present invention has a practical value for industrial and commercial production.

公开(公告)号：US20200030783A1

公开(公告)日：2020-01-30

申请号：US16508470

申请日：2019-07-11

申请人： Dow Global Technologies LLC

发明人： Jerzy Klosin ,  Kara A. Milbrandt ,  Scott D. Boelter ,  David R. Wilson ,  Mari S. Rosen ,  Dean M. Welsh ,  Peter M. Margl ,  Kyoung Moo Koh ,  David M. Pearson ,  Rafael Huacuja

IPC分类号： B01J31/24 ,  B01J31/14 ,  B01J31/18 ,  C07C2/36 ,  C07F9/6568 ,  C07F9/6584 ,  C07F11/00 ,  C07F17/02 ,  C07F9/6571 ,  B01J31/22

摘要： The invention relates to oligomerization of olefins, such as ethylene, to higher olefins, such as a mixture of 1-hexene and 1-octene, using a catalyst system that comprises a) a source of chromium b) one or more activators and c) a phosphacycle-containing ligating compound. Additionally, the invention relates to a phosphacycle-containing ligating compound and a process for making said compound.

公开(公告)号：US10519091B2

公开(公告)日：2019-12-31

申请号：US16216037

申请日：2018-12-11

申请人： EVONIK DEGUSSA GMBH

发明人： Rui Sang ,  Peter Kucmierczyk ,  Kaiwu Dong ,  Ralf Jackstell ,  Matthias Beller ,  Robert Franke

IPC分类号： C07C51/14 ,  C07C53/00 ,  B01J31/00 ,  C07C51/25 ,  B01J31/22 ,  B01J31/24 ,  B01J31/30 ,  C07C53/128

摘要： Process for Pd-catalyzed hydroxycarbonylation of diisobutene:ligand/Pd ratio.

公开(公告)号：US20190375693A1

公开(公告)日：2019-12-12

申请号：US16546583

申请日：2019-08-21

申请人： Chevron Phillips Chemical Company LP

发明人： Jared T. FERN ,  Orson L. SYDORA ,  Uriah J. KILGORE ,  Steven M. BISCHOF ,  Eric R. FERNANDEZ

IPC分类号： C07C2/32 ,  B01J8/00 ,  B01J31/14 ,  B01J31/24

摘要： Disclosed herein are processes, systems, and reaction systems for the oligomerization of ethylene to form an ethylene oligomer product in a reaction zone using a catalyst system having i) a chromium component comprising a heteroatomic ligand chromium compound complex of the type disclosed herein, and ii) an aluminoxane. A C3+ olefin can be present in the reaction zone for a period of time, where the C3+ olefin is not an ethylene oligomer formed in-situ within the reaction zone.

公开(公告)号：US10472313B1

公开(公告)日：2019-11-12

申请号：US16278156

申请日：2019-02-17

申请人： Graphene Laboratories Inc.

发明人： Sergey Voskresensky

IPC分类号： C07C45/00 ,  C07C67/00 ,  B01J31/00 ,  C07C67/343 ,  B01J31/24 ,  C07C69/78 ,  C07C49/813

摘要： A process for synthesizing trifluoroketones, such as 1-(5-chloro[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone.