公开(公告)号：US07552728B2

公开(公告)日：2009-06-30

申请号：US10534383

申请日：2003-11-05

Applicant: Stanley George Bonney ,  Michael Birsha Davies ,  Paul Kenneth Rand

Inventor： Stanley George Bonney ,  Michael Birsha Davies ,  Paul Kenneth Rand

IPC: A61M11/00 ,  A61M11/06 ,  A61M11/08

CPC classification number: A61M15/009 ,  A61M15/0026 ,  A61M15/0068 ,  A61M15/0076 ,  A61M15/0081 ,  A61M15/08

Abstract: A drug delivery device for delivering to a patient a drug composition from a container which contains the drug composition where the container is adapted to be placed in a dispensing mode thereof on application of an actuating condition thereto is disclosed. The device includes a dispensing unit adapted to receive the container, the dispensing unit having an actuating mechanism operable to apply the actuating condition to the container and an outlet through which the drug composition is dispensable from the device, and a removable casing unit for the dispensing unit. The dispensing and casing units have securing features for releasably, fixedly securing the units together, and the dispensing unit is operable to apply the actuating condition to the container when fixedly secured to the casing unit and when independent from the casing unit.

Abstract translation: 本发明公开了一种药物输送装置，用于向包含药物组合物的容器中的药物组合物递送药物组合物，其中容器适于在施加致动条件时将其置于其分配模式中。 所述装置包括适于容纳所述容器的分配单元，所述分配单元具有可操作以将所述致动条件施加到所述容器的致动机构和所述药物组合物可从所述装置分配的出口以及用于所述分配的可移除的壳体单元 单元。 分配和套管单元具有用于可释放地，固定地将单元固定在一起的固定特征，并且分配单元可操作以在固定地固定到壳体单元时以及独立于壳体单元时将致动条件施加到容器。

公开(公告)号：US20080245362A1

公开(公告)日：2008-10-09

申请号：US12066014

申请日：2006-09-06

Applicant: George Moessis ,  Jack Vaisman ,  Philip Jenkinson ,  David Bull ,  Andy Wyatt

Inventor： George Moessis ,  Jack Vaisman ,  Philip Jenkinson ,  David Bull ,  Andy Wyatt

IPC: A61M11/06 ,  B05B1/08 ,  B05B17/06

CPC classification number: B05B17/0615 ,  A61M11/002 ,  A61M15/0085 ,  B05B15/654 ,  B05B17/0607

Abstract: The present invention relates to a nebuliser and method of nebulising a liquid. The nebuliser includes a nebulisation chamber (1) having a well (2) adapted to contain a liquid (3) to be nebulised. An energy source in the form of an ultrasonic transducer (6) has as a curved energy transmission surface (7). This curved energy transmission surface defines a focal point (8) and a focal length (9). The energy source is spaced from the well such that the distance between the focal point and the energy source intrudes into the well not greater than 50% of the focal length. Preferably the well is shaped such that during nebulisation the level of the liquid in the well remains within a predetermined focal length range to thereby provide a substantially constant flowrateut of nebulised liquid. The nebuliser may also include a deflector baffle or fountain diverter (16) which acts to deflect the nebulised liquid fountain rising from the well. In order to reduce large droplets leaving the nebulisation chamber a circuitous or labyrinthine path is also provided between the well and the exit (13) of the nebulisation chamber

Abstract translation: 本发明涉及雾化器和雾化液体的方法。 雾化器包括具有适于容纳待雾化的液体（3）的井（2）的雾化室（1）。 超声波换能器（6）形式的能量源具有弯曲的能量传输表面（7）。 该弯曲的能量传输表面限定焦点（8）和焦距（9）。 能量源与井隔开，使得焦点和能量源之间的距离进入阱不大于焦距的50％。 优选地，孔的形状使得在雾化期间，阱中的液体水平保持在预定焦距范围内，从而提供基本恒定的雾化液体的流速。 喷雾器还可以包括偏转器挡板或喷泉转向器（16），其用于使从井中升起的喷雾液体喷嘴偏转。 为了减少离开雾化室的大液滴，在井和喷雾室的出口（13）之间还设有迂回或迷路的路径

公开(公告)号：US20080110458A1

公开(公告)日：2008-05-15

申请号：US11866283

申请日：2007-10-02

Applicant: Sudarsan Srinivasan ,  David Ammann ,  Donald Brookman ,  Niranjan Maharajh ,  Gary Grollimund ,  F. Murphy Sprinkel ,  Douglas D. McRae

Inventor： Sudarsan Srinivasan ,  David Ammann ,  Donald Brookman ,  Niranjan Maharajh ,  Gary Grollimund ,  F. Murphy Sprinkel ,  Douglas D. McRae

IPC: A61M16/00 ,  A61M11/06 ,  A61B19/00

CPC classification number: A61M16/14 ,  A61M11/001 ,  A61M11/007 ,  A61M11/041 ,  A61M11/042 ,  A61M15/00 ,  A61M15/025 ,  A61M16/024 ,  A61M16/0808 ,  A61M16/1065 ,  A61M16/1075 ,  A61M2205/128 ,  A61M2205/3368 ,  A61M2205/505

Abstract: A drug delivery system, which includes an aerosol generator unit, a pumping unit, a flow tube, at least one condensate collector and an aerosol transition adapter. The aerosol generator forms an aerosol from a liquid formulation, which is partially vaporized. The pumping unit supplies the liquid formulation to the aerosol generator unit and a flow tube having an inlet end in fluid communication with an outlet of the aerosol generator unit and an outlet adapted for connection to a patient interface, which supplies ventilation to a patient's lungs. The system also includes at least one condensate collector adapted to collect condensed liquid or liquid produced by the aerosol generator unit, and a transition adapter arranged to mix aerosol produced by the aerosol generator unit with heated air and directs the mixed aerosol into the inlet end of the flow passage.

Abstract translation: 药物递送系统，其包括气溶胶发生器单元，泵送单元，流动管，至少一个冷凝物收集器和气溶胶转换适配器。 气溶胶发生器从液体制剂形成气溶胶，其被部分汽化。 泵送单元将液体制剂供应到气溶胶发生器单元和具有与气溶胶发生器单元的出口流体连通的入口端的流管和适于连接到患者接口的出口，该患者接口向患者的肺提供通气。 该系统还包括至少一个冷凝收集器，适于收集由气溶胶发生器单元产生的冷凝液体或液体;以及转换适配器，其被布置成将由气溶胶发生器单元产生的气溶胶与加热空气混合，并将混合气溶胶引导到 流路。

公开(公告)号：US20070119984A1

公开(公告)日：2007-05-31

申请号：US11698528

申请日：2007-01-26

Applicant: John Woods

Inventor： John Woods

IPC: B05B7/32 ,  F23D14/28 ,  A61M11/06 ,  B65D83/00

CPC classification number: B65D83/303

Abstract: A spray nozzle assembly is disclosed which provides for increased atomization, a finer spray, and a reduced tendency of the apparatus to clog. The nozzle assembly includes a discharge opening, an expansible bladder, and optionally, a pressure chamber through which the spray material must pass prior to exiting the spray container through the discharge opening. As material exiting the container passes through the expansible bladder and the pressure chamber, pressure is built up, which results in increased shearing and atomization of the spray material.

Abstract translation: 公开了一种喷嘴组件，其提供增加的雾化，更细的喷雾和减少的装置堵塞的趋势。 喷嘴组件包括排出口，可膨胀气囊和任选的压力室，喷射材料在通过排出口离开喷雾容器之前必须通过该压力室。 当离开容器的材料通过可膨胀气囊和压力室时，压力被建立，这导致喷雾材料的剪切和雾化增加。

公开(公告)号：US06962151B1

公开(公告)日：2005-11-08

申请号：US10129498

申请日：2000-10-27

Applicant: Martin Knoch ,  Manfred Keller ,  Roland Stangl ,  Thomas Gallem ,  Rainer Liening-Ewert ,  Markus Urich

Inventor： Martin Knoch ,  Manfred Keller ,  Roland Stangl ,  Thomas Gallem ,  Rainer Liening-Ewert ,  Markus Urich

IPC: A61M11/00 ,  A61M11/06 ,  A61M15/00

CPC classification number: B05B17/0646 ,  A61M15/0015 ,  A61M15/0018 ,  A61M15/0085

Abstract: An inhalation nebulizer (1) includes an aerosol generator (2) that has a diaphragm (22) vibrated by a vibration generator (23). The inhalation nebulizer (1) includes a liquid storage container (21) that is in fluid contact with the diaphragm (22). A liquid contained in the storage container (21) is atomized into a mixing chamber (3) through openings in the diaphragm and can subsequently be inhaled by a patient.

Abstract translation: 吸入雾化器（1）包括气溶胶发生器（2），其具有由振动发生器（23）振动的隔膜（22）。 吸入式雾化器（1）包括与隔膜（22）流体接触的液体储存容器（21）。 容纳在储存容器（21）中的液体通过隔膜中的开口被雾化到混合室（3）中，并随后被患者吸入。

公开(公告)号：US20050235987A1

公开(公告)日：2005-10-27

申请号：US11062519

申请日：2005-02-22

Applicant: Gerald Smaldone ,  Lucy Palmer

Inventor： Gerald Smaldone ,  Lucy Palmer

IPC: A61M11/00 ,  A61M11/06 ,  A61M16/00 ,  A61M16/04 ,  A61M16/08 ,  A62B7/00 ,  A62B9/06

CPC classification number: A61M15/009 ,  A61M11/00 ,  A61M11/06 ,  A61M16/0057 ,  A61M16/04 ,  A61M16/0463 ,  A61M16/0465 ,  A61M16/0484 ,  A61M16/08 ,  A61M16/0808 ,  A61M16/0833

Abstract: The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit. The treatment means also concentrates the therapeutic agent specifically at affected sites in the lung such that therapeutic levels of administrated drug are achieved without significant systemic exposure of the patient to the drug. The invention further provides a dose control device to govern this specialized regimen.

公开(公告)号：US06948492B2

公开(公告)日：2005-09-27

申请号：US10129578

申请日：2001-08-15

Applicant: Daniel P. Wermeling ,  Ryan Vallance ,  Aravind Balasubramaniam ,  Bruce Lanier Walcott ,  John Alan Main ,  James E. Lumpp, Jr.

Inventor： Daniel P. Wermeling ,  Ryan Vallance ,  Aravind Balasubramaniam ,  Bruce Lanier Walcott ,  John Alan Main ,  James E. Lumpp, Jr.

IPC: A61M11/00 ,  A61M11/06 ,  A61M13/00 ,  A61M15/00 ,  A61M15/08 ,  B05B11/02

CPC classification number: A61M15/08 ,  A61M11/06 ,  A61M15/0045 ,  A61M15/008 ,  A61M15/0081 ,  A61M15/0083 ,  A61M2205/0266 ,  A61M2205/073 ,  A61M2210/0618 ,  B05B11/02

Abstract: An apparatus and method for the self-administration of a plurality of doses of an intranasal liquid pharmaceutical composition, including opioid analgesics, that includes a drug delivery device containing a plurality of sealed vials, each vial containing a predetermined volume of the pharmaceutical composition, a pump assembly for conveying the liquid pharmaceutical composition from the interior of the vial and discharging it as a nasal spray in response to manual activation by the patient, and programmable means for sequentially advancing a vial to the ready position after passage of a prescribed time interval following the last activation of the delivery device.

Abstract translation: 一种用于自我施用多个剂量的鼻内液体药物组合物（包括阿片类镇痛药）的装置和方法，其包括含有多个密封小瓶的药物递送装置，每个小瓶含有预定体积的药物组合物， 泵组件，用于从液体药物组合物的内部输送液体药物组合物并将其作为响应于患者手动激活的鼻喷雾而排出;以及可编程装置，用于在经过规定的时间间隔后经过规定的时间间隔后续地将小瓶运送到就绪位置 最后激活传送设备。

公开(公告)号：US20050196345A1

公开(公告)日：2005-09-08

申请号：US11111589

申请日：2005-04-21

Applicant: Julia Diederichs ,  Wolfgang Koch ,  Hubert Lodding ,  Regina Reszka ,  Horst Windt

Inventor： Julia Diederichs ,  Wolfgang Koch ,  Hubert Lodding ,  Regina Reszka ,  Horst Windt

IPC: A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61M11/06 ,  A61M15/00 ,  B05B7/00 ,  B05B7/06 ,  A61L9/04 ,  A61M11/00

CPC classification number: A61K9/0075 ,  A61K9/0078 ,  A61K9/127 ,  A61K9/1272 ,  A61K9/1277 ,  A61M11/001 ,  A61M11/06 ,  A61M15/0086 ,  B05B7/0012 ,  B05B7/066

Abstract: The invention relates to a compressed air inhaler for the pulmonary application of a liposomal powder aerosol that carries active agents or is uncharged. The aim of the invention, providing an inhaler with which the pulmonary application of, in particular, liposomes carrying active agent is enabled without forced breathing manoeuvres and with which the active agent can be transferred to the desired place of action in a sufficient amount without the active agent escaping, is solved by the compressed air inhaler for the pulmonary application of a liposomal powder aerosol entailing a receptacle 20 for a watery liposome dispersion, in which the liposomes carrying the active agent are dispersed in water, which is connected via a liquid dosing device 19 with an atomiser nozzle 1 and with a drying unit 17 such as an atomising chamber for the spray drying of the liposomes, to which said drying unit an exit 18 such as a mouthpiece is connected, in which the atomiser nozzle 1 has separate supply channels 14,16 for the compressed air and the liposome dispersion-FIG. 1-. The aim of the invention is further a new kind of powder aerosol comprising liposomes or nano-particles.

Abstract translation: 本发明涉及用于肺部施用携带活性剂或不带电的脂质体粉末气溶胶的压缩空气吸入器。 本发明的目的是提供一种吸入器，其具有特别是携带活性剂的脂质体的肺部应用，而无需强制呼吸机动，并且活性剂可以以足够的量转移到所需的作用位置，而没有 通过压缩空气吸入器解决了用于肺部施用脂质体粉末气溶胶的溶剂，所述脂质体粉末气溶胶带有用于水性脂质体分散体的容器20，其中携带活性剂的脂质体分散在水中，其通过液体剂量 装置19具有雾化器喷嘴1和干燥单元17，例如用于喷雾干燥脂质体的雾化室，所述干燥单元连接诸如接口的出口18，其中雾化器喷嘴1具有单独的供应 用于压缩空气和脂质体分散体的通道14,16。 1 - 。 本发明的目的是进一步的一种新型的包含脂质体或纳米颗粒的粉末气溶胶。

公开(公告)号：US20050171466A1

公开(公告)日：2005-08-04

申请号：US11038359

申请日：2005-01-19

Applicant: Pierre Diemunsch

Inventor： Pierre Diemunsch

IPC: A61M11/00 ,  A61M11/04 ,  A61M11/06 ,  A61M13/00 ,  A61M19/00 ,  A61M37/00

CPC classification number: A61M19/00 ,  A61B17/3474 ,  A61M11/041 ,  A61M11/042 ,  A61M11/06 ,  A61M13/00 ,  A61M13/003 ,  A61M2202/0241 ,  A61M2202/064 ,  A61M2202/203

Abstract: An apparatus for conditioning an insufflation gas has an inlet for the delivery of an insufflation gas to a conditioning chamber. The conditioning chamber is used to charge the insufflation gas with a medicament by blowing the insufflation gas through a humidifying liquid containing the medicament. The insufflation gas charged with the medicament flows from the charging device to an outlet and can be delivered to the abdominal cavity of a human or animal, where it ensures optimum distribution of the medicament.

Abstract translation: 用于调节吹入气体的装置具有用于将吹入气体输送到调节室的入口。 调节室用于通过吹入吹入气体通过含有药物的加湿液体而用药剂对吹入气体进行充气。 装有药剂的吹入气体从充电装置流出到出口，并且可以被输送到人或动物的腹腔，其确保药物的最佳分布。

公开(公告)号：US20050166918A1

公开(公告)日：2005-08-04

申请号：US10512072

申请日：2002-10-28

Applicant: Andrea Trombi

Inventor： Andrea Trombi

IPC: A61M11/00 ,  A61M11/06 ,  A61M15/00 ,  A61M16/10

CPC classification number: A61M11/06 ,  A61M11/002 ,  A61M15/0015 ,  A61M15/0018

Abstract: Nebulising apparatus (1) for aerosol therapy comprising a nebuliser ampoule (2) provided with at least an opening (4;5) for aspirating and/or expelling air from/to the environment and with a mouthpiece (3) for dispensing a nebulised medical product. The apparatus is provided with a valve (6) for regulating a flow of air into and/or out of the ampoule (2) and it comprises: a shutter (8) able to move between an operative configuration corresponding to an obstruction of said opening (4;5) and an operative configuration of consent to the passage of the flow of air; a ring (9) connected to the shutter (8) to anchor it to a tubular portion (2a) of the ampoule (2); a plurality of deformable connecting elements (10) between the ring (9) and the shutter (8) to allow the shutter (8) to move between the aforesaid operative configurations.

Abstract translation: 一种用于气溶胶治疗的喷雾装置（1），包括设置有至少一个开口（4; 5）的雾化器安瓿（2），用于从/向环境吸入和/或排出空气，以及用于分配雾化医疗 产品。 该装置设置有用于调节进入和/或离开安瓿（2）的空气流的阀（6），并且其包括：快门（8），能够在对应于所述开口 （4; 5）和同意通过空气流动的有效配置; 连接到所述挡板（8）以将其锚定到所述安瓿（2）的管状部分（2a）的环（9）; 在所述环（9）和所述挡板（8）之间的多个可变形连接元件（10），以允许所述挡板（8）在上述操作构型之间移动。