PREVENTION OF INDWELLING DEVICE RELATED INFECTION: COMPOSITION AND METHODS
    73.
    发明申请
    PREVENTION OF INDWELLING DEVICE RELATED INFECTION: COMPOSITION AND METHODS 审中-公开
    预防感染器官相关感染:组合物和方法

    公开(公告)号:US20130183363A1

    公开(公告)日:2013-07-18

    申请号:US13570786

    申请日:2012-08-09

    Abstract: Catheters used for medical treatment, e.g., hemodialysis are filled with a locking solution, usually heparin between treatments. To prevent infections, antimicrobial or antibiotic substances have been used as locking solution alone or in combination with antithrombotic substances. It has been found that these locking solutions are rapidly washed out from the catheter tip. The invention describes a thixotropic gel that can be used as locking solution. Beneficial, substances, e.g., antimicrobial or antibiotic substances can be added to the gel. A preferred antimicrobial substance is taurolidin alone or in combination with salicylic acid or one of its salts.

    Abstract translation: 用于医疗,例如血液透析的导管填充有锁定溶液,通常在治疗之间是肝素。 为了防止感染,抗微生物剂或抗生素物质已被用作单独的锁定溶液或与抗血栓形成物质组合使用。 已经发现这些锁定溶液从导管末端快速洗出。 本发明描述了可用作锁定溶液的触变凝胶。 可以将有益的物质,例如抗微生物剂或抗生素物质加入到凝胶中。 优选的抗微生物物质是单独的taurolidin或与水杨酸或其盐之一组合。

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