公开(公告)号：US10526371B2

公开(公告)日：2020-01-07

申请号：US15743357

申请日：2016-07-13

申请人： Universiteit Gent ,  Vrije Universiteit Brussel

发明人： Richard Hoogenboom ,  Annemieke Madder ,  Steven Ballet

IPC分类号： A61K47/42 ,  C07K7/02 ,  C07K7/06 ,  A61K31/496

摘要： Provided are hydrogel-forming peptides that comprise at least one dyad of hydrophobic amino acid residues in which one is a β3- or β2-homo amino acid residue. The hydrogels derived from these peptides can be loaded with biological materials and can be used in physiological conditions.

公开(公告)号：US10479832B2

公开(公告)日：2019-11-19

申请号：US15129792

申请日：2015-03-30

申请人： Universiteit Gent ,  VIB VZW

发明人： Dirk Elewaut ,  Els Louagie ,  Nele Juchtmans

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61K38/22

摘要： The disclosure provides compositions and methods comprising a sialoadhesin binding moiety for treating metabolic and genetic bone disease, especially for treating a bone disorder of hyper-resorption of bone and/or enhanced activation of osteoclasts.

公开(公告)号：US20190336428A1

公开(公告)日：2019-11-07

申请号：US16424927

申请日：2019-05-29

申请人： Colgate-Palmolive Company ,  KATHOLIEKE UNIVERSITEIT LEUVEN ,  UNIVERSITEIT GENT

发明人： Hansruedi STETTLER ,  Wim TEUGHELS ,  Marc QUIRYNEN ,  Nico BOON

IPC分类号： A61K8/60 ,  A61K8/19 ,  C12Q1/02 ,  A61K8/81 ,  A61K8/99 ,  A61K8/73 ,  A61Q11/00 ,  A61K31/047 ,  A61K8/25 ,  A61K8/29 ,  A61K8/46 ,  A61K8/34 ,  A61K31/7032 ,  A61K31/702 ,  A61K31/7008

摘要： The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from D-turanose, D-melezitose, D-lactitol, myo-inositol, and N-acetyl-D-mannosamine; and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.

公开(公告)号：US20190231889A1

公开(公告)日：2019-08-01

申请号：US16312219

申请日：2017-07-03

申请人： UNIVERSITEIT GENT

发明人： Richard HOOGENBOOM ,  Bart VERBRAEKEN

IPC分类号： A61K47/59 ,  A61K47/69 ,  A61K48/00 ,  C08G73/02

CPC分类号： A61K47/59 ,  A61K47/6907 ,  A61K48/0008 ,  C08G73/0233 ,  C12N15/87

摘要： The invention relates to invention relates to a statistical copolymer represented by the following formula (I): Ini-[Ox]m-[Oz]n-Nuc (I) wherein: Ini represents a residue of an initiator of cationic polymerization, Nuc represents a residue of a nucleophilic agent, Ox represents N(R1)CHRaCHRa; each R1 independently represents H or C(O)R11; and R11 independently represents optionally substituted C1-12 alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; Oz represents N(R2)CHRaCHRaCHRa; each R2 independently represents C(O)R21 or H; and R21 independently represents optionally substituted C1-12 alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or optionally substituted aryl; each Ra independently represents H, linear or branched C1-3 alkyl; m≥5; n≥5; m+n≥20; 3:97≤m:n≤97:3. The statistical copolymers of the present invention exhibit useful properties that can be exploited in the medical field, especially in polymer micelles for drug delivery and polyplexes for DNA delivery.

公开(公告)号：US10358718B2

公开(公告)日：2019-07-23

申请号：US14760170

申请日：2014-01-16

申请人： UNIVERSITEIT GENT

发明人： Christophe Detavernier ,  Davy Deduytsche ,  Amit Kumar Roy

IPC分类号： C23C16/02 ,  C23C16/40 ,  C23C16/52 ,  C23C16/455

摘要： A method is described for providing a hydrophilic effect to a fluoropolymer, e.g. polytetrafluoroethylene (PTFE) material. The method comprises obtaining an at least partly hydrophobic fluoropolymer material, applying a plasma and/or ozone activation step and depositing an inorganic coating using an atomic layer deposition process. Plasma activation step and/or said atomic layer deposition process thereby comprises using process parameters determining a high interaction probability between one or more precursors for the atomic layer deposition process and the fluoropolymer material so as to obtain a coated fluoropolymer material having a contact angle with water below 30°.

公开(公告)号：US10330625B2

公开(公告)日：2019-06-25

申请号：US14404666

申请日：2013-05-31

申请人： UNIVERSITEIT GENT

发明人： Michel De Paepe ,  Kathleen De Kerpel ,  Hugo Caniere

IPC分类号： G01N27/22 ,  F28F27/02 ,  G01N33/26 ,  G01N33/00 ,  G01N33/28 ,  G01N27/02

摘要： The present invention relates to a method and system for determining the void fraction of a multi-phase system in a channel. The method comprises the steps of measuring a void fraction dependent parameter of the multi-phase system, obtaining a flow regime of the multi-phase system, and determining the void fraction of the multi-phase system taking into account a set of one or more relationships between the void fraction dependent parameter and the void fraction, the set of relationships being specific for the obtained flow regime.

公开(公告)号：US10295451B2

公开(公告)日：2019-05-21

申请号：US15738227

申请日：2016-06-28

申请人： IMEC VZW ,  Universiteit Gent

发明人： Bendix Schneider ,  Peter Bienstman ,  Joni Dambre ,  Geert Vanmeerbeeck ,  Liesbet Lagae

IPC分类号： G01N15/02 ,  G03H1/02 ,  G03H1/04 ,  G01N15/14 ,  G01N15/00

摘要： A device for extracting at least one object characteristic of an object (106) is presented, the device comprising: a light sensor (101) for recording a hologram of an object and a processing unit (102) coupled to the light sensor and configured for extracting at least one object characteristic from the hologram; wherein the processing unit is configured for extracting the at least one object characteristic from a section of the hologram without reconstructing an image representation of the object. Further, a device (200) for sorting an object (106), a method for identifying an object and a method for sorting objects is presented.

公开(公告)号：US10280410B2

公开(公告)日：2019-05-07

申请号：US14002320

申请日：2012-02-29

申请人： Jan Tavernier ,  Samuel Lievens

发明人： Jan Tavernier ,  Samuel Lievens

IPC分类号： C12N9/12 ,  C12N15/10 ,  C12N15/62 ,  C12Q1/48 ,  G01N33/542

摘要： The disclosure relates to a cytoplasmic protein complex comprising: (a) a first recombinant fusion protein comprising a kinase, fused to a first interaction polypeptide; and (b) a second recombinant fusion protein comprising a domain comprising a reporter phosphorylation site, whereby the domain is fused to a second interaction polypeptide. The disclosure relates further to a method to detect compound-compound-interaction using the cytoplasmic protein complex, and to cells comprising such cytoplasmic protein complex.

公开(公告)号：US10251866B2

公开(公告)日：2019-04-09

申请号：US14352154

申请日：2012-10-18

申请人： Universiteit Gent

发明人： Jean Paul Remon ,  Chris Vervaet

IPC分类号： A61K9/10 ,  A61K9/14 ,  A61K47/12 ,  A61K47/26 ,  A61K31/4184

摘要： The present invention in general relates to a pharmaceutical suspension comprising nano-sized cocrystals of at least one active ingredient and at least one dicarboxylic acid. It in particular relates to a pharmaceutical suspension comprising nano-sized cocrystals of at least one anthelmintic drug and at least one dicarboxylic acid. The invention further relates to uses, methods for use and methods for manufacturing the pharmaceutical suspension according to this invention.

公开(公告)号：US10246548B2

公开(公告)日：2019-04-02

申请号：US15533648

申请日：2015-12-17

申请人： UNIVERSITEIT GENT ,  ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS

发明人： Filip Du Prez ,  Johan Winne ,  Wim Denissen ,  Ludwik Leibler ,  Renaud Nicolaÿ

IPC分类号： C08G63/02 ,  C08G18/67 ,  C08G83/00 ,  C08J3/24 ,  C08J11/04 ,  B29B17/00 ,  B29B17/04 ,  C07C225/16 ,  C07C229/30 ,  C07D295/185 ,  C08G18/72 ,  C08J11/06

摘要： The present invention relates to a composition comprising a polymeric network having at least one unit of formula (I), (II), and/or (III); wherein the composition is obtained by contacting at least one compound A comprising at least two functions selected from the group of function of formula —X—C(═O)—CHR1-C(═O)—R2, —C(═O)—C≡C—R2; or —C(═O)—CR1═CR2—NR4R5; wherein at least 25% by weight of compounds A have a functionality ≤5, with % by weight relative to the total weight of compounds A; with at least one compound B comprising at least one —NH2, or —NH3+ groups; wherein X, R1, R2, R3, R4, R5, L1 and L2 have the same meaning as that defined in the claims. The present invention also relates to a compound comprising at least two units and at most 5 units of formula (I), (II), and/or (III), described hereinabove. The present invention also relates to processes for preparing the composition and the compounds, to material, articles, and polymers comprising or using the compositions and compounds, and the use thereof.