公开(公告)号：US07457665B1

公开(公告)日：2008-11-25

申请号：US11262362

申请日：2005-10-29

Applicant: Ivan Osorio ,  Mark G. Frei

Inventor： Ivan Osorio ,  Mark G. Frei

IPC: A61N1/365

CPC classification number: A61B5/4094 ,  A61B5/02405 ,  A61B5/02455 ,  A61B5/0452 ,  A61B5/0456 ,  A61B5/686 ,  A61B5/7282 ,  A61B2560/0475 ,  A61N1/36053 ,  A61N1/36064 ,  A61N1/36114 ,  A61N1/36135

Abstract: The present invention uses electrical stimulation of the vagus nerve to treat epilepsy with minimized or no effect on the heart. Treatment is carried out by an implantable signal generator, one or more implantable electrodes for electrically stimulating a predetermined stimulation site of the vagus nerve, and a sensor for sensing characteristics of the heart such as heart rate. The heart rate information from the sensor can be used to determine whether the vagus nerve stimulation is adversely affecting the heart. Once threshold parameters are met, the vagus nerve stimulation may be stopped or adjusted. In an alternative embodiment, the invention may include a modified pacemaker to maintain the heart in desired conditions during the vagus nerve stimulation. In yet another embodiment, the invention may be simply a modified pacemaker having circuitry that determines whether a vagus nerve is being stimulated. In the event that the vagus nerve is being stimulated, the modified pacemaker may control the heart to maintain it within desired conditions during the vagus nerve stimulation.

Abstract translation: 本发明使用迷走神经的电刺激来治疗癫痫，对心脏具有最小化或不起作用。 治疗由可植入信号发生器，用于电刺激迷走神经的预定刺激部位的一个或多个可植入电极以及用于感测心脏特征的传感器例如心率进行。 来自传感器的心率信息可用于确定迷走神经刺激是否对心脏有不利影响。 一旦达到阈值参数，就可以停止或调整迷走神经刺激。 在替代实施例中，本发明可以包括修改的起搏器，以在迷走神经刺激期间将心脏保持在期望的状态。 在另一个实施例中，本发明可以简单地是具有确定是否正在刺激迷走神经的电路的改进的起搏器。 在迷走神经被刺激的情况下，修改的起搏器可以控制心脏在迷走神经刺激期间将其保持在期望的条件内。

公开(公告)号：US07006859B1

公开(公告)日：2006-02-28

申请号：US10622238

申请日：2003-07-18

Applicant: Ivan Osorio ,  Naresh C. Bhavaraju

Inventor： Ivan Osorio ,  Naresh C. Bhavaraju

IPC: A61B5/042 ,  A61N1/05

CPC classification number: A61N1/0531 ,  A61B5/0478 ,  A61N1/0539 ,  A61N1/36017

Abstract: An electrode with three-dimensional capabilities for detection and control of brain state changes of a subject. The electrode includes a disk portion having an upper surface and a lower surface, and a shaft portion secured to and extending perpendicularly outwardly from the lower surface of the disk portion; the shaft portion having an outer surface. The disk portion and shaft portion may include one or more recording or stimulating contact surfaces structured to operatively interact with the brain of a subject. Insulating material isolates each of the recording or stimulating contact surfaces from each other. At least one conductor operatively and separately connect each of the recording or stimulating contact surfaces in communication with external apparatus. The disk portion and shaft portion are structured relative to each other to operatively provide support and anchoring for each other while providing three-dimensional capabilities for detection and control of brain state changes of a subject. Modified embodiments include insertible/retractable electrode wires, both contained in channels and sheathed in axially displaceable cannulae; activating mechanisms for inserting/retracting the electrode wires and/or cannulae; and multiple shaft portions.

公开(公告)号：US20240149065A1

公开(公告)日：2024-05-09

申请号：US18388879

申请日：2023-11-13

Applicant: IVAN OSORIO

Inventor： IVAN OSORIO

IPC: A61N1/36 ,  A61B5/00 ,  A61B5/372

CPC classification number: A61N1/36064 ,  A61B5/372 ,  A61B5/4094 ,  A61B5/4848 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/36146 ,  A61N1/0529

Abstract: A method for assessment, optimization and logging of the effects of a therapy for a medical condition, including (a) receiving into a signal processor input signals indicative of the subject's brain activity; (b) characterizing the spatio-temporal behavior of the brain activity using the signals; (c) delivering a therapy to a target tissue of the subject; (d) characterizing the spatio-temporal effect of the therapy on the brain activity; (e) in response to the characterizing, optimizing at least one parameter of the therapy if the brain activity has not been satisfactorily modified and/or has been adversely modified by the therapy; (f) characterizing the spatio-temporal effect of the at least one optimized parameter; and (g) logging to memory the at least one optimized parameter. A computer readable program storage unit encoded with instructions that, when executed by a computer, performs the method.

公开(公告)号：US11642527B2

公开(公告)日：2023-05-09

申请号：US16911592

申请日：2020-06-25

Applicant: Ivan Osorio

Inventor： Ivan Osorio

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/36064 ,  A61N1/36053 ,  A61N1/36114 ,  A61N1/36139 ,  A61N1/36185 ,  A61N1/0556 ,  A61N1/36117

Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.

公开(公告)号：US11524111B2

公开(公告)日：2022-12-13

申请号：US16447045

申请日：2019-06-20

Applicant: FLINT HILLS SCIENTIFIC, L.L.C.

Inventor： Ivan Osorio

IPC: A61M5/172 ,  A61N1/36 ,  A61F7/12 ,  A61B17/132 ,  A61F7/00 ,  A61F7/10 ,  A61F7/02

Abstract: We report a method of treating an epileptic seizure in a patient, comprising: detecting said epileptic seizure, based on body data from said patient; and reducing a flow of blood to a brain of said patient in response to said detected seizure; wherein said reducing is effected by: increasing the parasympathetic input to said patient's heart, such as by electrically stimulating a parasympathetic nervous structure, applying cooling energy to a sympathetic nervous structure, or administering a cholinergic or a sympatho-blocking agent to said patient. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

公开(公告)号：US20220354438A1

公开(公告)日：2022-11-10

申请号：US17870097

申请日：2022-07-21

Applicant: FLINT HILLS SCIENTIFIC, L.L.C.

Inventor： IVAN OSORIO

IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/08 ,  A61B5/021 ,  A61B5/0245 ,  A61B5/11 ,  A61N1/39 ,  A61N1/36 ,  A61N1/365 ,  A61B5/16 ,  G16H50/30 ,  A61B5/349 ,  A61F7/00 ,  A61M5/172

Abstract: A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively. The second method includes determining an increased risk of death related to epilepsy if indices are extreme values, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A computer readable program storage device is also provided. Also provided is a method for receiving body data, determining a cardiac, an arousal, a responsiveness, or a kinetic index, determining an increased or increasing risk of death over a first time window relating to a patient with epilepsy and issuing a warning and logging relevant information.

公开(公告)号：US11305121B2

公开(公告)日：2022-04-19

申请号：US14203394

申请日：2014-03-10

Applicant: Flint Hills Scientific, L.L.C.

Inventor： Ivan Osorio

IPC: A61N1/36 ,  A61N1/372

Abstract: We report a method of automatically titrating an electrical therapy administered to a patient by an implanted medical device to a target dosage, comprising programming the medical device with a programmed electrical therapy comprising a first target value for a first therapy parameter; programming at least one titration parameter for automatically adjusting the first therapy parameter from a first value to the first target value over a titration time period initiating the electrical therapy, wherein the first therapy parameter comprises said first value; and automatically titrating the electrical therapy by making a plurality of adjustments to the value of the first therapy parameter, whereby the first electrical therapy parameter is changed from the first value to the first target value according to a titration function. We also report a medical device system configured to implement the method.

公开(公告)号：US11179094B2

公开(公告)日：2021-11-23

申请号：US16188356

申请日：2018-11-13

Applicant: Flint Hills Scientific, L.L.C.

Inventor： Ivan Osorio ,  Mark G. Frei

IPC: A61B5/00 ,  A61B5/024 ,  A61N1/36 ,  A61B5/35 ,  A61B5/316 ,  A61B5/349 ,  A61B5/352 ,  A61B5/364 ,  A61B5/0245

Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.

公开(公告)号：US20210244343A1

公开(公告)日：2021-08-12

申请号：US17241279

申请日：2021-04-27

Applicant: FLINT HILLS SCIENTIFIC, L.L.C.

Inventor： IVAN OSORIO

IPC: A61B5/00 ,  A61B5/0205 ,  A61B5/11

Abstract: We report a method of a method for detecting an epileptic seizure, comprising providing a first body signal reference value; determining a current body signal value from a time series of body signals; comparing the current body signal value and the first reference value; determining a work level of the patient; determining whether the current body signal value comprises an ictal component, based on the work level and the comparing; issuing a detection of an epileptic seizure in response to the determination that the current body signal value comprises the ictal component; and taking at least one further action (e.g. warning, delivering a therapy, etc.), based on the detection. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.

公开(公告)号：US11006890B2

公开(公告)日：2021-05-18

申请号：US16524702

申请日：2019-07-29

Applicant: Flint Hills Scientific, L.L.C.

Inventor： Ivan Osorio

IPC: A61B5/00 ,  A61B5/08 ,  A61B5/0205 ,  A61B5/113 ,  A61B5/11 ,  A61N1/36 ,  A61B5/318 ,  A61B5/0245 ,  A61N1/365 ,  A61B5/389 ,  A61B5/021 ,  A61B5/024 ,  A61B5/0531 ,  A61B7/04 ,  A61B8/08 ,  A61B5/026

Abstract: A method, comprising receiving at least one of a signal relating to a first cardiac activity and a signal relating to a first body movement from a patient; triggering at least one of a test of the patient's responsiveness, awareness, a second cardiac activity, a second body movement, a spectral analysis test of the second cardiac activity, and a spectral analysis test of the second body movement, based on at least one of the signal relating to the first cardiac activity and the signal relating to the first body movement; determining an occurrence of an epileptic event based at least in part on said one or more triggered tests; and performing a further action in response to said determination of said occurrence of said epileptic event. Further methods allow classification of epileptic events. Apparatus and systems capable of implementing the method.