公开(公告)号：US20140050744A1

公开(公告)日：2014-02-20

申请号：US13945052

申请日：2013-07-18

Applicant: Genentech, Inc.

Inventor： Mark Dennis ,  William Mallet ,  Paul Polakis

IPC: A61K47/48

CPC classification number: A61K47/6803 ,  A61K31/337 ,  A61K31/4025 ,  A61K31/4196 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/537 ,  A61K31/555 ,  A61K31/7068 ,  A61K31/7072 ,  A61K38/07 ,  A61K38/08 ,  A61K45/06 ,  A61K47/6817 ,  A61K47/6835 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/3015 ,  C07K16/303 ,  C07K16/3069 ,  C07K16/3092 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  Y10T428/13

Abstract: The invention is directed to antibody drug conjugate compositions of matter useful for the diagnosis and treatment of tumors in mammals and to methods of using those compositions of matter for the same.

公开(公告)号：US20140030281A1

公开(公告)日：2014-01-30

申请号：US13936284

申请日：2013-07-08

Applicant: Genentech, Inc.

Inventor： Paul Polakis ,  Andrew Polson ,  Susan Diane Spencer ,  Shang-Fan Yu ,  Bing Zheng

IPC: A61K47/48 ,  A61K45/06 ,  A61K31/706

CPC classification number: A61K47/6807 ,  A61K31/706 ,  A61K45/06 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6867

Abstract: The invention provides anti-CD22 antibodies and immunoconjugates and methods of using the same.

Abstract translation: 本发明提供抗CD22抗体和免疫缀合物及其使用方法。

公开(公告)号：US20130316402A1

公开(公告)日：2013-11-28

申请号：US13766150

申请日：2013-02-13

Applicant: GENENTECH, INC.

Inventor： Mark S. Dennis ,  Bonnee Rubinfeld ,  Paul Polakis ,  Aya Jakobovits

IPC: C07K16/30

CPC classification number: G01N33/57434 ,  A61K38/05 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6851 ,  A61K47/6869 ,  A61K47/6871 ,  A61K49/0002 ,  A61K49/0058 ,  A61K51/1045 ,  A61K51/1072 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3069 ,  C07K16/40 ,  C07K17/00 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/515 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/92

Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided.

公开(公告)号：US20130157289A1

公开(公告)日：2013-06-20

申请号：US13692888

申请日：2012-12-03

Applicant: Genentech, Inc.

Inventor： Mark Dennis ,  Jan Marik ,  Paul Polakis ,  Bonnee Rubinfeld ,  Simon Williams

IPC: G01N33/68 ,  C07K16/30

CPC classification number: C07K16/40 ,  A61K47/6811 ,  A61K47/6871 ,  A61K51/1072 ,  A61K51/1075 ,  A61K51/1093 ,  A61K51/1096 ,  A61K2039/505 ,  C07B59/008 ,  C07B2200/05 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/92 ,  G01N33/534 ,  G01N33/57492 ,  G01N33/60 ,  G01N33/6893

Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.