公开(公告)号：US10442968B2

公开(公告)日：2019-10-15

申请号：US14913568

申请日：2014-08-25

Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

Inventor： Hiroshi Suzuki ,  Yoshiyuki Komoda ,  Ruri Hidema

IPC: C09K5/00 ,  C09K5/06 ,  B01J13/22 ,  B01J13/14 ,  F28D20/02 ,  C01B33/12 ,  B01J2/08 ,  B01J13/20

Abstract: Provided is a latent heat transfer material that is micro-encapsulated, said material exhibiting superior mechanical strength and heat resistance. A production method for the latent heat transfer material that is micro-encapsulated in a hard shell comprises: 1) a step in which a perforate hollow silica particle is manufactured; 2) a step in which the phase change material is sealed inside the perforate hollow silica particle by inserting the perforate hollow silica particle in a molten solution of the phase change material and repeatedly subjecting the same to vibrations such as ultrasound oscillations; 3) a step in which the perforate hollow silica particle having the phase change material sealed within is washed in a saturated aqueous solution of the phase change material; and 4) a step in which perhydropolysilazane is used to coat the outer shell of the perforate hollow silica particle with silica.

公开(公告)号：US10379609B2

公开(公告)日：2019-08-13

申请号：US14891578

申请日：2014-05-22

Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

Inventor： Takashi Nagamatsu ,  Tatsuhiko Ueki

IPC: H04N7/18 ,  H04N9/47 ,  G06F3/01 ,  B60K35/00 ,  G08B21/06 ,  G06K9/00 ,  H04N5/225 ,  H04N5/247 ,  G06T7/80 ,  G06T7/73 ,  G02B27/00 ,  A61B3/113 ,  A61B5/18 ,  G02B27/01

Abstract: Provided are a line-of-sight measurement device and method, which perform automatic calibration of line-of-sight measurement for distance-gazing users. The device is provided with: an optical axis-calculating means for calculating the optical axes of both the left and right eyeballs when viewing two distant points; a discrepancy calculating means for calculating, with the visual axes of the left and right eyeballs during distance-gazing being parallel as a constraint, the discrepancies between the optical axes and the visual axes for both the left and right eyeballs; and a fixation point-calculating means for calculating the user's fixation point on the basis of the discrepancy between the optical axes and the visual axes. For the constraint, the outer product value of the respective vectors of the left and right eye visual axes is 0 or the inner product of the respective unit vectors of the left and right eye visual axes is 1.

公开(公告)号：US20180169156A1

公开(公告)日：2018-06-21

申请号：US15737758

申请日：2016-05-30

Applicant: National University Corporation Kobe University ,  Osaka University

Inventor： Toshiro Shirakawa ,  Takane Katayama ,  Yoshiko Hashii ,  Keiichi Ozono

IPC: A61K35/745 ,  A61K38/17 ,  C07K19/00 ,  C07K14/195 ,  C12N15/74 ,  A61K39/00 ,  C07K14/47

Abstract: A cancer vaccine that can be orally administered can be provided through the use of a transformed Bifidobacterium capable of expressing and displaying a WT1 protein. The WT1 protein expressed and displayed by the transformed Bifidobacterium is a protein covering most of a WT1 protein unlike a WT1 peptide vaccine restricted to a certain HLA. A cancer vaccine using the transformed Bifidobacterium as an active ingredient is applicable to patients of various HLA types.

公开(公告)号：US09968368B2

公开(公告)日：2018-05-15

申请号：US14548402

申请日：2014-11-20

Applicant: TEIJIN MEDICAL TECHNOLOGIES CO., LTD ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

Inventor： Masaki Okuno ,  Hiroshi Morii ,  Katsuya Nada ,  Ryosuke Kuroda

IPC: A61B17/17

CPC classification number: A61B17/1714

Abstract: A drill guide has a main body in which a drill insertion hole is formed and plural projection portions to be inserted into plural bone tunnels. The plural projection portions project forward from the main body parallel with the center line of the drill insertion hole, a virtual drill insertion hole which extends from the drill insertion hole of the main body is formed between the plural projection portions parallel with their center lines by cutting out confronting portions of the plural projection portions, and the length of at least one of the drill insertion hole and the virtual drill insertion hole is 5 mm or more. The drill guide can guide a drill so as to be correctly between plural bone tunnels bored through a living body bone without causing axis deviation so that a link bone tunnel for connecting the plural bone tunnels can be formed between them in the same direction as their direction.

公开(公告)号：US20180009771A1

公开(公告)日：2018-01-11

申请号：US15543547

申请日：2015-12-15

Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

Inventor： Ryosuke Matsubara ,  Akihiro Ando ,  Masahiko Hayashi

IPC: C07D271/08

CPC classification number: C07D271/08 ,  A61K31/4245

Abstract: The present invention provides: a furoxan compound having a fluorine atom as a substituent group on the ring structure thereof; and a novel nitric oxide donor including the compound. The present invention relates to a fluorofuroxan compound represented by general formula (1) or (2). The compound of formula (1) can be manufactured by reacting a fluoride salt with a nitrofuroxan compound to substitute the nitro group with a fluoro group. The compound of formula (2) can be manufactured by subjecting the compounds of formula (1) to isomerization by irradiation with light.

公开(公告)号：US09730666B2

公开(公告)日：2017-08-15

申请号：US14875112

申请日：2015-10-05

Applicant: Toshiba Medical Systems Corporation ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

Inventor： Hitoshi Yamagata ,  Yoshiharu Ohno

IPC: G06K9/00 ,  A61B6/00 ,  A61B6/03 ,  G06T7/00 ,  G06T7/20 ,  G06T11/00 ,  G06T15/08 ,  A61B5/05 ,  A61B5/055

CPC classification number: A61B6/5264 ,  A61B5/055 ,  A61B6/032 ,  A61B6/486 ,  A61B6/50 ,  A61B6/5217 ,  A61B6/5229 ,  A61B6/5235 ,  G06F19/00 ,  G06T7/0012 ,  G06T7/215 ,  G06T11/003 ,  G06T15/08 ,  G06T2200/04 ,  G06T2207/10081 ,  G06T2207/30061 ,  G06T2210/41 ,  G06T2211/40

Abstract: According to one embodiment, a medical image processing apparatus includes an image storage memory, a calculation circuitry, a level decision circuitry, and an output interface circuitry. The image storage memory stores data of a plurality of images in different respiratory phases. The calculation circuitry calculates a motion amount of a region between the plurality of images for each pixel or area. The level decision circuitry decides a level concerning a severity of chronic obstructive pulmonary disease for each pixel or area. The output interface circuitry outputs information concerning the decided level.

公开(公告)号：US09629947B2

公开(公告)日：2017-04-25

申请号：US14759219

申请日：2013-12-26

Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

Inventor： Takashi Yamane

IPC: A61M1/10 ,  F04D3/00 ,  F04D29/18 ,  F04D29/52 ,  F04D29/64 ,  F04D13/06 ,  F04D29/54

CPC classification number: A61M1/1012 ,  A61M1/10 ,  A61M1/1008 ,  A61M1/101 ,  A61M1/1013 ,  A61M1/1017 ,  A61M1/1029 ,  A61M1/1031 ,  A61M1/12 ,  A61M1/122 ,  F04D3/00 ,  F04D13/0646 ,  F04D29/181 ,  F04D29/528 ,  F04D29/548 ,  F04D29/648

Abstract: An axial flow blood pump comprises: an impeller (2) that rotates around an axis and is provided with axial flow blades on the peripheral surface thereof, a permanent magnet inside the impeller (2), and a dynamic bearing or a pivot bearing; a first casing (5) that surrounds the peripheral surface of the impeller (2) and is provided with an intake port (11); an annular fixed element (6) that generates a rotating magnetic field in the impeller (2) and can be fitted onto the outer surface of the first casing (5); an outlet port (12); a second casing (3) that is provided with guide vanes (diffusers) (31) in the inner surface thereof; and a socket member (4) that is fittably and securely mounted onto the outer peripheral surface of the second casing (3) and is provided with a joining portion that can join with the fixed element (6).

公开(公告)号：US20170073670A1

公开(公告)日：2017-03-16

申请号：US15124021

申请日：2015-03-04

Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

Inventor： Keiji NISHIDA ,  Akihiko KONDO ,  Satomi KOJIMA

IPC: C12N15/10 ,  C12N15/11 ,  C12N9/22 ,  C12N9/78

CPC classification number: C12N15/1024 ,  C07K2319/00 ,  C07K2319/81 ,  C12N9/22 ,  C12N9/78 ,  C12N15/102 ,  C12N15/11 ,  C12N2310/3513 ,  C12Y305/04005

Abstract: The present invention provides a method of modifying a targeted site of a double stranded DNA, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded DNA and a nucleic acid base converting enzyme are bonded, with the double stranded DNA, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one chain of the double stranded DNA in the targeted site.

Abstract translation: 本发明提供了修饰双链DNA的靶位点的方法，包括使其中特异性结合选择的双链DNA中的靶核苷酸序列的核酸序列识别模块和核酸接触的复合物的步骤 与双链DNA键合，将靶位点中的一个或多个核苷酸转化成其它一个或多个核苷酸，或者删除一个或多个核苷酸，或者将一个或多个核苷酸插入靶位点，至少不断裂 目标位点双链DNA的一条链。

公开(公告)号：US20160377557A1

公开(公告)日：2016-12-29

申请号：US15262448

申请日：2016-09-12

Applicant: National University Corporation Kobe University ,  Integral Geometry Science Inc.

Inventor： Kenjiro KIMURA ,  Noriaki KIMURA

IPC: G01N22/00 ,  G06T11/00

CPC classification number: G01N22/00 ,  G01N22/02 ,  G06T11/003

Abstract: A scattering tomography method includes: radiating waves to an object from a plurality of transmitting antenna elements aligned on a side surface of a case; receiving scattered waves by a plurality of receiving antenna elements aligned on the side surface of the case; and reconstructing an image relating to information on an interior of the object using scattered wave data representing the scattered waves. In the reconstructing, a reconstruction function for reconstructing the image relating to the information on the interior of the object is set in advance for a three-dimensional space having the same shape as the case, a scattering field equation which the reconstruction function satisfies is constructed, a visualization function that is obtained by solving the scattering field equation is derived from the scattered wave data, and the image relating to the information on the interior of the object is reconstructed using the visualization function.

Abstract translation: 散射层析成像方法包括：从对准在壳体的侧表面上的多个发射天线元件向物体辐射波; 通过在壳体的侧表面上排列的多个接收天线元件接收散射波; 以及使用表示散射波的散射波数据，重建与物体内部的信息相关的图像。 在重建中，对于具有与情况相同形状的三维空间，预先设定用于重建与物体内部的信息相关的图像的重建功能，构成重建功能满足的散射场方程 ，通过求解散射场方程得到的可视化函数是从散射波数据得出的，并且利用可视化函数重建与物体内部信息有关的图像。

公开(公告)号：US20160361565A1

公开(公告)日：2016-12-15

申请号：US15107842

申请日：2014-12-24

Applicant: NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  ALFRESA PHARMA CORPORATION ,  KANAI JUYO KOGYO CO., LTD.

Inventor： Takumi FUKUMOTO ,  Ryohei SASAKI ,  Tsutomu MORIHARA ,  Yoshio SASAI ,  Yoshihisa FURUTA ,  Tsutomu OBATA ,  Yoshitaka TAGAMI

IPC: A61N5/10 ,  A61L31/06 ,  A61L31/18 ,  A61B90/00 ,  A61L31/14

CPC classification number: A61N5/10 ,  A61B90/04 ,  A61B2090/0436 ,  A61B2090/0815 ,  A61L31/06 ,  A61L31/14 ,  A61L31/146 ,  A61L31/148 ,  A61L31/18 ,  A61N5/1049 ,  A61N2005/1094 ,  A61N2005/1096 ,  G21F3/00 ,  C08L67/04

Abstract: A radiotherapy spacer is disclosed that has both flexibility for allowing it to gently cover the organs of various shapes along their surfaces and pressure resistance for preventing itself from being crushed under the pressure between organs and thus enabling it to retain its own shape and continuously ensure the therapeutic space. The spacer comprises a fiber assembly formed of entangled biocompatible fibers, which may be bioabsorbable, such as nonwoven fabric, and is characterized in that the density of the fiber assembly is 0.05 g/cm3 to 0.2 g/cm3.

Abstract translation: 公开了一种放射治疗间隔物，其具有允许其轻轻地覆盖沿着其表面的各种形状的器官和耐压性的柔性，以防止其在器官之间的压力下被压碎，从而使其能够保持其自身形状并且连续地确保 治疗空间。 间隔物包括由络合的生物相容性纤维形成的纤维组合物，其可以是生物可吸收的，例如非织造织物，其特征在于纤维组合物的密度为0.05g / cm 3至0.2g / cm 3。