公开(公告)号：US10176578B2

公开(公告)日：2019-01-08

申请号：US14436379

申请日：2013-10-15

申请人： ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS

发明人： Louis Puybasset ,  Damien Galanaud ,  Habib Benali ,  Vincent Perlbarg ,  Stephane Lehericy

IPC分类号： G06K9/00 ,  G06T7/00 ,  A61B5/00 ,  A61B5/055 ,  G01R33/563 ,  G06K9/46 ,  G06K9/52 ,  G06K9/62 ,  G06T7/238

摘要： The invention relates to an ex vivo method for detecting and/or quantifying brain injuries. The invention also relates to an ex vivo method for monitoring the evolution of a brain injury, and to an ex vivo method for predicting when a patient will come out of a coma. The invention is particularly applicable in the field of medicine and in the field of clinical studies.

公开(公告)号：US10159684B2

公开(公告)日：2018-12-25

申请号：US15616971

申请日：2017-06-08

申请人： INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE PARIS DESCARTES ,  UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) ,  ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS (APHP)

发明人： Nicolette Farman ,  Frederic Jaisser ,  Francine Behar-Cohen ,  Selin Aractingi ,  Van Tuan Nguyen

IPC分类号： A61K31/585 ,  A61K31/573 ,  A61K9/00 ,  A61K45/06

摘要： The present invention relates to method and pharmaceutical compositions for preventing glucocorticoid-induced corneal or skin thinning. In particular, the present invention relates to a mineralocorticoid receptor antagonist for topical use in a method for preventing or reducing glucocorticoid-induced corneal or skin thinning in a subject in need thereof. The invention also relates to a topical pharmaceutical composition comprising an amount of at least one glucocorticoid and an amount of at least one mineralocorticoid receptor antagonist or inhibitor of MR expression for use in a method for treating an inflammatory skin disease or an inflammatory disease of the cornea or of the anterior segment of the eye in a subject in need thereof.

公开(公告)号：US10144975B2

公开(公告)日：2018-12-04

申请号：US14395105

申请日：2013-04-19

申请人： Institut Pasteur ,  Universite Paris Descartes ,  Assistance Publique-Hopitaux de Paris ,  Pathoquest ,  Ecole Nationale Veterinaire D'Alfort

发明人： Marc Eloit ,  Justine Cheval ,  Charles Hebert ,  Marc Lecuit

IPC分类号： C12Q1/68 ,  C12Q1/70

摘要： The present invention relates to the use of the measure of anelloviral load for the determination of immunosuppression. More precisely, the present invention provides a method for characterizing the immunosuppressed or non-immunosuppressed status of a subject, comprising the steps of determining the anelloviral load from a biological sample of the said subject, and determining from the said comparison the immunosuppressed or non-immunosuppressed status. The determination of the immunosuppressed status of the subject can then be used to design or adapt a therapeutic treatment.

公开(公告)号：US20180282816A1

公开(公告)日：2018-10-04

申请号：US15763854

申请日：2016-09-29

申请人： NSERM (Institut National de la Sante et de la Recherche Medicale) ,  Universite Nice Sophia Antipolis ,  Assistance Publique-Hopitaux de Paris (APHP)

发明人： Jean-Ehrland Ricci ,  Johanna Chiche ,  Catherine Thieblemont

IPC分类号： C12Q1/6886 ,  C07K16/28 ,  C07K16/30 ,  A61K39/395 ,  A61K38/50 ,  A61K31/436 ,  A61K31/155 ,  A61P35/00 ,  G01N33/574

摘要： The invention relates to an in vitro method for determining the metabolic status of a lymphoma comprising a step of determining the level of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression in lymphoma cells, wherein a low level of GAPDH expression is indicative of oxidative phosphorylation (OXPHOS) status. The invention also relates to an in vitro method for predicting the responsiveness of a patient afflicted with a lymphoma to a treatment with a metabolic inhibitor selected from the group consisting of mitochondrial metabolic inhibitors and glutamine metabolism inhibitors comprising a step of determining the level of GAPDH expression in lymphoma cells obtained from said patient, wherein a low level of GAPDH expression is predictive of a response to a treatment with a metabolic inhibitor.

公开(公告)号：US20180271471A1

公开(公告)日：2018-09-27

申请号：US15763938

申请日：2016-09-29

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  Sorbonne Universite ,  Universite Paris Diderot - Paris 7 ,  Centre National de la Recherche Scientifique ,  ECOLE SUPERIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS ,  UNIVERSITE PARIS DESCARTES ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

发明人： Jean PROVOST ,  Anikitos GAROFALAKIS ,  Mathieu PERNOT ,  Mickaël TANTER ,  Bertrand TAVITIAN ,  Thomas VIEL

IPC分类号： A61B6/00 ,  A61B6/03 ,  A61B8/06 ,  A61B8/08 ,  A61N7/00

CPC分类号： A61B6/5247 ,  A61B6/032 ,  A61B6/037 ,  A61B6/4258 ,  A61B6/4417 ,  A61B8/06 ,  A61B8/4416 ,  A61B8/488 ,  A61B8/5261 ,  A61N7/00

摘要： The invention relates to a method for determining at least one property of an object, the method comprising a step of: a) obtaining first data relative to the object by an ultrasound imaging technique imaging the object at a frame rate superior to 300 Hz, characterized in that the method further comprises a step of: b) obtaining second data relative to the object by imaging the object with at least one of a X-ray and a γ-ray, and c) determining the at least one property of the object based on the first data and the second data.

公开(公告)号：US20180185149A1

公开(公告)日：2018-07-05

申请号：US15910500

申请日：2018-03-02

申请人： Assistance Publique - Hopitaux de Paris

发明人： Emmanuel Lansac

IPC分类号： A61F2/24

CPC分类号： A61F2/2442 ,  A61B2017/00243 ,  A61F2/24 ,  A61F2/2409 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/246 ,  A61F2/2478 ,  A61F2/2481

摘要： Aortic ring (1) made of a flexible, suturable and biocompatible material, having a length, in the implanted state, making it possible to maintain a normal aortic ring diameter, said ring comprising, or being able to be combined with, means for holding the ring in a closed position in its site of implantation, in particular in a subvalvular plane.

公开(公告)号：US10006903B2

公开(公告)日：2018-06-26

申请号：US14337826

申请日：2014-07-22

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE PARIS DESCARTES ,  ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS ,  UNIVERSITE PIERRE ET MARIE CURIE—PARIS 6

发明人： Jocelyne Just ,  Benedicte Michaud ,  Jean-Francois Bach ,  Lucienne Chatenoud

IPC分类号： A61K39/00 ,  A61K39/35 ,  A61K39/36 ,  A61K39/38 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  G01N33/50 ,  G01N33/68

CPC分类号： G01N33/505 ,  G01N33/6869 ,  G01N2333/5406 ,  G01N2333/5437 ,  G01N2800/24

摘要： The present invention relates to an in vitro use of a number of IL-4 and/or IL-13 secreting T-cells as a biomarker for diagnosing and/or monitoring an IgE-dependent allergic disease.

公开(公告)号：US20180110742A1

公开(公告)日：2018-04-26

申请号：US15789269

申请日：2017-10-20

申请人： ICM (INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE) ,  APHP (ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 (UPMC) ,  UNIVERSITE CATHOLIQUE DE LOUVAIN

发明人： Pierre POUGET ,  Marcus MISSAL

IPC分类号： A61K31/135 ,  A61P25/16 ,  A61P25/18

CPC分类号： A61K31/135 ,  A61P25/16 ,  A61P25/18

摘要： Disclosed is the use of N-Methyl-D-aspartate (NMDA) antagonists at sub-anesthetic doses for the treatment of motor dysfunction in mental or psychiatric disorders with occurrence of aggressive and/or impulsive behavior.

公开(公告)号：US20180098711A1

公开(公告)日：2018-04-12

申请号：US15568839

申请日：2016-04-22

申请人： Institut National de la Sante et de la Recherche Medical (INSERM) ,  Universite Paris Diderot - Paris 7 ,  Assistance Publique - Hopitaux de Paris ,  Univesite de Versailles Saint-Quentin-en-Yvelines

发明人： Benjamin LEPORQ ,  Simon LAMBERT ,  Berard VAN BEERS

IPC分类号： A61B5/055 ,  A61B5/00 ,  G01R33/48 ,  G01R33/561 ,  G01R33/565

CPC分类号： A61B5/055 ,  A61B5/4872 ,  G01R33/4828 ,  G01R33/5615 ,  G01R33/5616 ,  G01R33/5618 ,  G01R33/56518 ,  G01R33/56527 ,  G01R33/56554

摘要： It is proposed a method for post-processing images of an region of interest in a subject, the images being acquired with a magnetic resonance imaging technique, the method for post-processing comprising at least the step of:—unwrapping the phase of each image,—extracting a complex signal over echo time for at least one pixel of the unwrapped images, and—calculating fat characterization parameters by using a fitting technique applied on a model, the model being a function which associates to a plurality of parameters each extracted complex signal, the plurality of parameters comprising at least two fat characterization parameters, the magnitude error and the phase error generated by the use of the bipolar readout gradients, the fitting technique being a non-linear least-square fitting technique using pseudo-random initial conditions.

公开(公告)号：US09909977B2

公开(公告)日：2018-03-06

申请号：US15029266

申请日：2014-10-15

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  ETAT FRANCAIS (MINISTERE DE LA DEFENSE), SERVICE DE SANTE DES ARMEES ,  ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS ,  UNIVERSITE PARIS DESCARTES

发明人： Pascale Gaussem ,  Anne Godier ,  Isabelle Gouin-Thibault ,  Bernard Le Bonniec ,  Anne-Celine Martin ,  Nyoucha Morravedge ,  Marc Samama

IPC分类号： G01N33/86 ,  G01N21/31 ,  G01N33/50 ,  G01N33/80 ,  G01N21/3577 ,  G01N33/49 ,  G01N21/17

CPC分类号： G01N21/31 ,  G01N21/3577 ,  G01N33/49 ,  G01N33/5002 ,  G01N33/80 ,  G01N33/86 ,  G01N2021/1748 ,  G01N2201/061 ,  G01N2333/75

摘要： The present invention relates to a method for determining both (a) the haematocrit value and (b) the fibrinogen content in whole blood of an individual in less than 5 minutes, as well as to associated portable apparatus.