公开(公告)号：US08224449B2

公开(公告)日：2012-07-17

申请号：US12493928

申请日：2009-06-29

Applicant: Rafael Carbunaru ,  Andrew DiGiore ,  Brett Schleicher

Inventor： Rafael Carbunaru ,  Andrew DiGiore ,  Brett Schleicher

IPC: A61N1/02

CPC classification number: A61N1/0556 ,  A61N1/372 ,  A61N1/37205

Abstract: An implantable microstimulator includes an elongate casing, a flap coupled directly to the casing, and electrodes attached to the flap such that the electrodes extend laterally relative to the longitudinal axis of the casing. The electrodes are coupled to active circuitry that is housed within the casing. Due to the lateral arrangement of the electrodes relative to the casing, effective operation of the microstimulator may still occur even after the microstimulator migrates away from the target stimulation site. Since there are not any leads associated with the microstimulator, the entire microstimulator, including the electrodes and the casing, is implanted adjacent to the target stimulation site. The electrodes may be configured for mono-polar or multi-polar stimulation. In one example, the microstimulator includes an insulative coating on the casing and the coating and the flap are contiguous.

Abstract translation: 可植入微型刺激器包括细长壳体，直接连接到壳体的瓣片和附接到瓣片的电极，使得电极相对于壳体的纵向轴线横向延伸。 电极耦合到容纳在壳体内的有源电路。 由于电极相对于外壳的横向布置，即使在微型激励器从目标刺激部位移开之后，微型激励器的有效操作也可能发生。 由于没有与微型激励器相关联的任何引线，所以包括电极和外壳在内的整个微型激励器被植入邻近目标刺激部位。 电极可以被配置为单极或多极刺激。 在一个示例中，微型激励器在壳体上包括绝缘涂层，并且涂层和皮瓣是连续的。

公开(公告)号：US08060209B2

公开(公告)日：2011-11-15

申请号：US12359144

申请日：2009-01-23

Applicant: Kristen N. Jaax ,  Todd K. Whitehurst ,  Andrew DiGiore

Inventor： Kristen N. Jaax ,  Todd K. Whitehurst ,  Andrew DiGiore

IPC: A61N1/00

CPC classification number: A61N1/36071 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/36007

Abstract: Methods and systems of treating a patient with ischemia pain include providing a stimulator, configuring one or more stimulation parameters to treat ischemia pain in a visceral organ, programming the stimulator with the one or more stimulation parameters, generating a stimulus configured to treat ischemia pain with the stimulator in accordance with the one or more stimulation parameters, and applying the stimulus with the stimulator to one or more stimulation sites in accordance with the one or more stimulation parameters.

Abstract translation: 治疗缺血性疼痛的患者的方法和系统包括提供刺激器，配置一个或多个刺激参数以治疗内脏器官中的缺血性疼痛，用所述一个或多个刺激参数编程所述刺激器，产生经配置以治疗缺血性疼痛的刺激 所述刺激器根据所述一个或多个刺激参数，以及根据所述一个或多个刺激参数将刺激器刺激施加到一个或多个刺激部位。

公开(公告)号：US07877136B1

公开(公告)日：2011-01-25

申请号：US11864494

申请日：2007-09-28

Applicant: Michael A. Moffitt ,  Kristen N. Jaax ,  Rafael Carbunaru ,  Andrew DiGiore

Inventor： Michael A. Moffitt ,  Kristen N. Jaax ,  Rafael Carbunaru ,  Andrew DiGiore

IPC: A61N1/36

CPC classification number: A61N1/36157 ,  A61N1/37205

Abstract: Methods and systems of enhancing transmission of a neural signal through damaged neural tissue include providing a stimulator, programming the stimulator with one or more stimulation parameters configured to enhance transmission of a neural signal through the damaged neural tissue, and applying a hyperpolarizing electrical stimulation current with the stimulator to the damaged neural tissue in accordance with the one or more stimulation parameters.

Abstract translation: 通过损伤的神经组织增强神经信号传播的方法和系统包括提供刺激器，用刺激器编程一个或多个刺激参数，其被配置为增强神经信号通过损伤的神经组织的传递，以及将超极化电刺激电流与 刺激器对损伤的神经组织按照一个或多个刺激参数。

公开(公告)号：US20100331920A1

公开(公告)日：2010-12-30

申请号：US12495645

申请日：2009-06-30

Applicant: Andrew DiGiore ,  Brett Schleicher ,  Greg Baldwin

Inventor： Andrew DiGiore ,  Brett Schleicher ,  Greg Baldwin

IPC: A61N1/02

CPC classification number: A61N1/3787

Abstract: Electrical energy is transcutaneously transmitted from an external charger to an implanted medical device. The external charger includes a charging head that is selectively shapeable to conform to the surface of a patient to enhance charge efficiency and patient comfort. An alternating current charging coil is housed in the charging head and configured for transcutaneously transmitting electrical energy to the implanted medical device. The shape of the coil is changeable as the charging head is shaped, and at least one sensor determines changes in the shape of the charging coil and causes the charge of the coil to be adjusted based on the coil shape.

Abstract translation: 电能从外部充电器经皮传输到植入式医疗装置。 外部充电器包括充电头，该充电头可选择地成形以符合患者的表面以增强充电效率和患者舒适度。 交流充电线圈被容纳在充电头中并且被配置为将电能经皮地传输到植入的医疗装置。 线圈的形状可以随着充电头的形状而变化，并且至少一个传感器确定充电线圈的形状的变化，并且基于线圈形状来调节线圈的充电。

公开(公告)号：US20100331919A1

公开(公告)日：2010-12-30

申请号：US12495605

申请日：2009-06-30

Applicant: Andrew DiGiore ,  Brett Schleicher ,  Greg Baldwin

Inventor： Andrew DiGiore ,  Brett Schleicher ,  Greg Baldwin

IPC: A61N1/02

CPC classification number: A61N1/3787

Abstract: Electrical energy is transcutaneously transmitted from an external charger to an implanted medical device. The external charger includes a charging head comprising a plurality of pivotable hinged sections for selectively shaping the charging head to conform to a surface of a patient. The external charger further includes an alternating current (AC) charging coil housed in the charging head for transcutaneously transmitting electrical energy to the implanted medical device. The charging head may also include one or more sensors for determining the shape of a charging coil in the charging head, which cause the charge of the coil to be adjusted based on the coil shape.

Abstract translation: 电能从外部充电器经皮传输到植入式医疗装置。 外部充电器包括充电头，该充电头包括多个可枢转的铰链部分，用于选择性地使充电头成形以符合患者的表面。 外部充电器还包括容纳在充电头中的交流（AC）充电线圈，用于将电能经皮地传输到植入的医疗装置。 充电头还可以包括用于确定充电头中的充电线圈的形状的一个或多个传感器，这导致基于线圈形状来调节线圈的充电。

公开(公告)号：US20100145357A1

公开(公告)日：2010-06-10

申请号：US12630761

申请日：2009-12-03

Applicant: Courtney Lane ,  Jesse Geroy ,  James C. Makous ,  Todd Whitehurst ,  Matthew Flowers ,  John Michael Barker ,  Terry Ferrell ,  John Swoyer ,  Brett Schleicher ,  Jeff Gagnon ,  Andrew Digiore ,  Ellis Garai ,  Kristen Jaax ,  Rafael Carbunaru

Inventor： Courtney Lane ,  Jesse Geroy ,  James C. Makous ,  Todd Whitehurst ,  Matthew Flowers ,  John Michael Barker ,  Terry Ferrell ,  John Swoyer ,  Brett Schleicher ,  Jeff Gagnon ,  Andrew Digiore ,  Ellis Garai ,  Kristen Jaax ,  Rafael Carbunaru

IPC: A61N1/05 ,  A61B17/00

CPC classification number: A61B17/0057 ,  A61B90/10 ,  A61B2090/103 ,  A61N1/0534 ,  A61N1/0539

Abstract: A burr hole plug comprises a plug base configured for being mounted around a burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base. The retainer further includes first and second slidable clamping mechanisms configured for securing the medical devices therebetween within the aperture of the plug base. A method comprises introducing the medical device through the burr hole, mounting a plug base around the burr hole, such that the medical device extends through the plug base aperture, mounting the retainer within the aperture of the plug base, and sliding the first and second clamping mechanisms secure the medical device therebetween.

Abstract translation: 毛刺孔塞包括构造成围绕钻孔安装的塞子基座。 插头基座包括一个孔，通过该孔可以使离开钻孔的细长医疗装置通过。 毛刺孔塞还包括保持器，其构造成用于安装在插头基座的孔内。 保持器还包括第一和第二可滑动夹紧机构，其被构造用于将医疗装置固定在插头基座的孔内。 一种方法包括：通过毛刺孔引导医疗装置，将插头基座安装在毛刺孔周围，使得医疗装置延伸穿过插头基座孔口，将保持器安装在插头基座的孔内，并将第一和第二 夹紧机构将医疗装置固定在其间。

公开(公告)号：US20100094387A1

公开(公告)日：2010-04-15

申请号：US12568428

申请日：2009-09-28

Applicant: Anne Margaret Pianca ,  Andrew DiGiore

Inventor： Anne Margaret Pianca ,  Andrew DiGiore

IPC: A61N1/05 ,  H01R43/00

CPC classification number: H01R43/00 ,  A61N1/0553 ,  A61N1/0558 ,  Y10T29/49117 ,  Y10T29/49204

Abstract: A lead includes a lead body with a distal end and a proximal end. A plurality of terminals are disposed at the proximal end of the lead body. A plurality of electrodes are disposed at the distal end of the lead body. Each electrode includes an electrode body and at least one anchoring member. The at least one anchoring member couples to the electrode body and extends into the lead body and beneath the electrode body to anchor the electrode to the lead body. A plurality of conductive wires electrically couple the plurality of electrodes to the plurality of terminals.

Abstract translation: 引线包括具有远端和近端的引线主体。 多个端子设置在引线体的近端处。 多个电极设置在引线体的远端。 每个电极包括电极体和至少一个锚定构件。 至少一个锚定构件耦合到电极体并且延伸到引线主体中并在电极体的下面，以将电极锚定到引线主体。 多个导线将多个电极电耦合到多个端子。

公开(公告)号：US20100076535A1

公开(公告)日：2010-03-25

申请号：US12237888

申请日：2008-09-25

Applicant: Anne M. Pianca ,  Courtney Lane ,  James C. Makous ,  Andrew DiGiore ,  Ellis Garai

Inventor： Anne M. Pianca ,  Courtney Lane ,  James C. Makous ,  Andrew DiGiore ,  Ellis Garai

IPC: A61N1/05

CPC classification number: A61N1/0534 ,  A61N1/0472 ,  A61N1/0529 ,  A61N1/36082

Abstract: A lead is configured and arranged for brain stimulation. The lead includes a proximal end and a distal end. The proximal end includes a plurality of terminals disposed at the proximal end. The distal end has a non-circular transverse cross-sectional shape and includes a plurality of electrodes disposed at the distal end. A plurality of conductive wires electrically couple at least one of the plurality of electrodes to at least one of the plurality of terminals.

Abstract translation: 铅的配置和排列用于脑刺激。 引线包括近端和远端。 近端包括设置在近端的多个端子。 前端具有非圆形横截面形状，并且包括设置在远端的多个电极。 多个导线将多个电极中的至少一个电连接到多个端子中的至少一个。

公开(公告)号：US20100023090A1

公开(公告)日：2010-01-28

申请号：US12509340

申请日：2009-07-24

Applicant: Kristen Jaax ,  Courtney Lane ,  Michael Moffitt ,  Andrew DiGiore ,  Mark Pierre ,  Kerry Bradley ,  Gregory Baldwin

Inventor： Kristen Jaax ,  Courtney Lane ,  Michael Moffitt ,  Andrew DiGiore ,  Mark Pierre ,  Kerry Bradley ,  Gregory Baldwin

IPC: A61N1/08

CPC classification number: A61N1/37235 ,  A61N1/36132 ,  A61N1/36146 ,  A61N1/37264

Abstract: A method and programmer for programming a neurostimulation device are provided. The method comprises varying a first stimulation parameter under user control, automatically varying a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters, outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the stimulation parameter sets, such that neural tissue is stimulated without undergoing neurological accommodation that would otherwise occur if the second stimulation parameter were not varied, and programming the neurostimulation device with a new set of stimulation parameters based on a result of the neural tissue stimulation The programmer comprises a user interface capable of receiving an input from a user, a processor configured for performing the previous steps, and output circuitry configured for transmitting the stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.

Abstract translation: 提供了一种用于编程神经刺激装置的方法和编程器。 该方法包括在用户控制下改变第一刺激参数，自动改变第二刺激参数，从变化的第一和第二刺激参数产生多个刺激参数集合，从神经刺激装置在多个电极之间输出脉冲电波形 根据刺激参数集，使得神经组织被刺激而不经历如果第二刺激参数没有变化否则会发生神经学调节，并且基于神经组织的结果用新的一组刺激参数来编程神经刺激装置 刺激编程器包括能够接收来自用户的输入，被配置为执行前述步骤的处理器的用户界面以及被配置为将刺激参数集和新刺激参数集发送到神经刺激装置的输出电路。

公开(公告)号：US20090192575A1

公开(公告)日：2009-07-30

申请号：US12358093

申请日：2009-01-22

Applicant: Rafael Carbunaru ,  Andrew DiGiore ,  Brett Schleicher

Inventor： Rafael Carbunaru ,  Andrew DiGiore ,  Brett Schleicher

IPC: A61N1/378

CPC classification number: A61N1/3787 ,  A61N1/37205 ,  A61N1/375 ,  H02J7/025 ,  H02J50/10 ,  H02J50/15 ,  H02J50/30 ,  H02J50/40

Abstract: Systems and techniques for thermal management of implantable medical devices. In one aspect an implantable device includes an active component configured to perform medical activities, a charging component configured to convert energy from outside a body in which the implantable device is implanted into potential energy, and a thermal barrier between the charging component and the active portion. The thermal barrier thermally isolates the charging component from the active portion so that thermal resistance between the charging component and the active component is above the thermal resistance between the charging component and the body.

Abstract translation: 可植入医疗器械的热管理系统和技术。 在一个方面，可植入装置包括被配置为执行医疗活动的有源部件，被配置为将能够植入可植入装置的身体外部的能量转换为势能的充电部件，以及充电部件与有源部分之间的热障碍 。 热隔离层使充电部件与有源部分热隔离，使得充电部件和有源部件之间的热阻高于充电部件与主体之间的热阻。